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The Constructibility Principle
Философия и космологияThe issue with current scientific models is that many models are speculative or paradoxical constructions central to Philosophy and Cosmology. The Constructibility Principle in this paper introduces a demarcation criterion.Michael Aaron Codydoaj +2 more sourcesEstimating the preclinical Alzheimer's disease course with multimodal data. [PDF]
Alzheimers DementAbstract INTRODUCTION
In observational studies of preclinical AD, an arbitrary “baseline” can obscure where an individual is located along a theoretical continuum. Optimizing longitudinal trajectories can distill multiple, non‐linearly distributed observations into a single metric and inform where an individual may be along the disease course.Townsend DL, Properzi MJ, Betthauser TJ, Klinger HM, Boyle R, Coughlan G, Hanseeuw BJ, Yang HS, Cody KA, Amariglio RE, Farrell M, Jacobs HIL, Shirzadi Z, Yau WY, Price JC, Chhatwal J, Rentz DM, Johnson KA, Sperling RA, Schultz AP, Buckley RF. +20 moreeuropepmc +2 more sourcesAbundant ammonia and nitrogen-rich soluble organic matter in samples from asteroid (101955) Bennu. [PDF]
Nat AstronOrganic matter in meteorites reveals clues about early Solar System chemistry and the origin of molecules important to life, but terrestrial exposure complicates interpretation.Glavin DP, Dworkin JP, Alexander CMO, Aponte JC, Baczynski AA, Barnes JJ, Bechtel HA, Berger EL, Burton AS, Caselli P, Chung AH, Clemett SJ, Cody GD, Dominguez G, Elsila JE, Farnsworth KK, Foustoukos DI, Freeman KH, Furukawa Y, Gainsforth Z, Graham HV, Grassi T, Giuliano BM, Hamilton VE, Haenecour P, Heck PR, Hofmann AE, House CH, Huang Y, Kaplan HH, Keller LP, Kim B, Koga T, Liss M, McLain HL, Marcus MA, Matney M, McCoy TJ, McIntosh OM, Mojarro A, Naraoka H, Nguyen AN, Nuevo M, Nuth JA, Oba Y, Parker ET, Peretyazhko TS, Sandford SA, Santos E, Schmitt-Kopplin P, Seguin F, Simkus DN, Shahid A, Takano Y, Thomas-Keprta KL, Tripathi H, Weiss G, Zheng Y, Lunning NG, Righter K, Connolly HC, Lauretta DS. +61 moreeuropepmc +2 more sourcesSex moderates the association between medial temporal tau pathology and cognitive decline: A multi‐cohort study [PDF]
Alzheimers DementAbstract Background
Existing positron emission tomography(PET) studies suggest that women exhibit greater regional tau burden than men, but the implications of this sex difference on cognitive trajectories remain elusive. We investigated sex differences on cognitive trajectories as a function of tau burden.Li A, Klinger H, Seto M, Birkenbihl C, Properzi M, Farrell M, Schultz A, Thibault E, Rissman R, Townsend D, Papp K, Amariglio R, Yang H, Raman R, Langford O, Donohue M, Betthauser T, Langhough R, Jonaitis E, Cody K, Johnson S, Rentz D, Johnson K, Sperling R, Buckley R, Coughlan G. +25 moreeuropepmc +2 more sourcesMLPerf Inference Benchmark [PDF]
International Symposium on Computer Architecture, 2019 Machine-learning (ML) hardware and software system demand is burgeoning. Driven by ML applications, the number of different ML inference systems has exploded.Vijayarāghava Reḍḍī, C. Cheng, David Kanter, Pete H Mattson, Guenther Schmuelling, Carole-Jean Wu, Brian Anderson, Maximilien Breughe, M. Charlebois, William Chou, Ramesh Chukka, Cody A. Coleman, S. Davis, Pan Deng, Greg Diamos, J. Duke, D. Fick, J. Gardner, Itay Hubara, S. Idgunji, Thomas B. Jablin, J. Jiao, Tom St. John, Pankaj Kanwar, David Lee, Jeffery Liao, Anton Lokhmotov, Francisco Massa, Peng Meng, Paulius Micikevicius, C. Osborne, Gennady Pekhimenko, Arun Tejusve Raghunath Rajan, Dilip Sequeira, Ashish Sirasao, Fei Sun, Hanlin Tang, Michael Thomson, F. Wei, E. Wu, Ling Xu, Koichiro Yamada, Bing Yu, George Y. Yuan, Aaron Zhong, P. Zhang, Yucheng Zhou +46 moresemanticscholar +1 more sourceDivergent Cortical Tau Positron Emission Tomography Patterns Among Patients With Preclinical Alzheimer Disease.
JAMA Neurol, 2022 Importance
Characterization of early tau deposition in individuals with preclinical Alzheimer disease (AD) is critical for prevention trials that aim to select individuals at risk for AD and halt the progression of disease.Young CB, Winer JR, Younes K, Cody KA, Betthauser TJ, Johnson SC, Schultz A, Sperling RA, Greicius MD, Cobos I, Poston KL, Mormino EC, Alzheimer’s Disease Neuroimaging Initiative and the Harvard Aging Brain Study. +12 moreeuropepmc +2 more sourcesHuman de novo mutation rates from a four-generation pedigree reference. [PDF]
NatureUnderstanding the human de novo mutation (DNM) rate requires complete sequence information1. Here using five complementary short-read and long-read sequencing technologies, we phased and assembled more than 95% of each diploid human genome in a four ...Porubsky D, Dashnow H, Sasani TA, Logsdon GA, Hallast P, Noyes MD, Kronenberg ZN, Mokveld T, Koundinya N, Nolan C, Steely CJ, Guarracino A, Dolzhenko E, Harvey WT, Rowell WJ, Grigorev K, Nicholas TJ, Goldberg ME, Oshima KK, Lin J, Ebert P, Watkins WS, Leung TY, Hanlon VCT, McGee S, Pedersen BS, Happ HC, Jeong H, Munson KM, Hoekzema K, Chan DD, Wang Y, Knuth J, Garcia GH, Fanslow C, Lambert C, Lee C, Smith JD, Levy S, Mason CE, Garrison E, Lansdorp PM, Neklason DW, Jorde LB, Quinlan AR, Eberle MA, Eichler EE. +46 moreeuropepmc +2 more sourcesFirst 12 patients with coronavirus disease 2019 (COVID-19) in the United States
medRxiv, 2020 Introduction: More than 93,000 cases of coronavirus disease (COVID-19) have been reported worldwide. We describe the epidemiology, clinical course, and virologic characteristics of the first 12 U.S. patients with COVID-19.S. Kujawski, Karen K. Wong, Jennifer P. Collins, L. Epstein, M. Killerby, C. Midgley, Glen R. Abedi, N. Ahmed, Olivia M Almendares, Francisco N. Alvarez, Kayla N Anderson, S. Balter, Vaughn Barry, Karri Bartlett, Karlyn D. Beer, Michael A. Ben-Aderet, I. Benowitz, H. Biggs, A. Binder, S. Black, Brandon J. Bonin, C. M. Brown, H. Bruce, Jonathan Bryant-Genevier, Alicia P. Budd, Diane Buell, Rachel Bystritsky, J. Cates, E. Charles, K. Chatham-Stephens, N. Chea, Howard Chiou, Demian Christiansen, V. Chu, S. Cody, Max Cohen, E. Conners, A. Curns, Vishal Dasari, P. Dawson, Traci Desalvo, G. Diaz, M. Donahue, S. Donovan, Lindsey M. Duca, Keith Erickson, Mathew D Esona, S. Evans, J. Falk, L. Feldstein, M. Fenstersheib, M. Fischer, R. Fisher, Chelsea Foo, Marielle J Fricchione, O. Friedman, Alicia M. Fry, R. Galang, M. M. García, Susan I. Gerber, G. Gerrard, Isaac Ghinai, P. Gounder, J. Grein, Cheri T. Grigg, J. Gunzenhauser, Gary I. Gutkin, M. Haddix, Aron J. Hall, George S. Han, J. Harcourt, K. Harriman, T. Haupt, Amber K. Haynes, Michelle L. Holshue, Cora R. Hoover, Jennifer C. Hunter, M. Jacobs, Claire Jarashow, M. Jhung, Kiran Joshi, T. Kamali, Shifaq Kamili, L. Kim, Moon J. Kim, Jan King, Hannah L. Kirking, A. Kita-Yarbro, R. Klos, Miwako Kobayashi, A. Kocharian, Kenneth K. Komatsu, Ram Koppaka, Jennifer Layden, Yan Li, S. Lindquist, S. Lindstrom, R. Link-Gelles, Joana Y. Lively, Michelle Livingston, K. Lo, J. Lo, Xiaoyan Lu, Brian Lynch, Larry Madoff, Lakshmi Malapati, Gregory Marks, Mariel A. Marlow, Glenn Mathisen, Nancy McClung, Olivia L McGovern, Tristan D. McPherson, M. Mehta, Audrey Meier, L. Mello, Sung-Sil Moon, M. Morgan, R. Moro, Janna R. Murray, Rekha Murthy, S. Novosad, Sara E. Oliver, Jennifer O'Shea, M. Pacilli, Clinton R. Paden, Mark Pallansch, Manisha Patel, Sajan Patel, I. Pedraza, Satish K. Pillai, T. Pindyck, Ian W. Pray, Krista J. Queen, Nichole Quick, Heather Reese, B. Rha, Heather Rhodes, Susan J. Robinson, P. Robinson, M. Rolfes, J. Routh, R. Rubin, Sarah L. Rudman, S. Sakthivel, Sarah E. Scott, Christopher Shepherd, V. Shetty, E. Smith, Shanon M. Smith, Bryan Stierman, W. Stoecker, R. Sunenshine, Regina Sy-Santos, A. Tamin, Ying Tao, D. Terashita, Natalie J Thornburg, S. Tong, Elizabeth Traub, Ahmet Tural, A. Uehara, T. Uyeki, Grace M Vahey, J. Verani, E. Villarino, Megan Wallace, Lijuan Wang, J. Watson, M. Westercamp, Brett L. Whitaker, Sara Wilkerson, Rebecca C. Woodruff, Jonathan Wortham, Tiffany Wu, Amy Xie, A. Yousaf, M. Zahn, Jing Zhang +177 moresemanticscholar +1 more sourceCIViC is a community knowledgebase for expert crowdsourcing the clinical interpretation of variants in cancer
Nature Genetics, 2017 CIViC is an expert-crowdsourced knowledgebase for Clinical Interpretation of Variants in Cancer describing the therapeutic, prognostic, diagnostic and predisposing relevance of inherited and somatic variants of all types.M. Griffith, N. Spies, K. Krysiak, Joshua F. McMichael, Adam C. Coffman, Arpad M. Danos, Benjamin J. Ainscough, Cody A. Ramirez, D. Rieke, Lynzey Kujan, Erica K. Barnell, A. Wagner, Zachary L. Skidmore, Amber Z. Wollam, Connor J. Liu, Martin R. Jones, Rachel L Bilski, R. Lesurf, Yang-Yang Feng, N. Shah, M. Bonakdar, L. Trani, Matthew K. Matlock, Avinash Ramu, Katie M. Campbell, Gregory C. Spies, Aaron P. Graubert, K. Gangavarapu, James M. Eldred, D. Larson, Jason R. Walker, Benjamin M. Good, Chunlei Wu, A. Su, R. Dienstmann, Adam A. Margolin, D. Tamborero, N. López-Bigas, Steven J. M. Jones, R. Bose, D. Spencer, L. Wartman, R. Wilson, E. Mardis, O. Griffith +44 moresemanticscholar +1 more source
