Results 41 to 50 of about 1,978,722 (300)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Book Review - Johnson, Jenell. American Lobotomy: A Rhetorical History

Transversal: International Journal for the Historiography of Science, 2017
Book review Johnson, Jenell. American Lobotomy: A Rhetorical History. Michigan: University of Michigan Press, 2013. 240 pp. ISBN: 978-0-472-03665-3.
Eliza Teixeira de Toledo
doaj   +1 more source

Restrictive ID policies: implications for health equity [PDF]

, 2018
We wish to thank Synod Community Services for their critical work to develop, support, and implement a local government-issued ID in Washtenaw County, MI.
AB Cox, AB Wilson, Alana M. W. LeBrón, AMW LeBrón, Brennan Center for Justice, E Graauw De, F Gany, J Bauer, J Hagan, Jorge Delva, K Hacker, Keta Cowan, L Mann, LJ Hardy, MA Barreto, Maria Ibarra-Frayre, N LaVigne, Nicole L. Novak, O Martinez, Olivia Temrowski, RB Toomey, RK Ditlmann, S Mathema, SD Rhodes, T Miller, TM Golash-Boza, TM Golash-Boza, William D. Lopez   +27 more
core   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Book review of Tribal Pastoralists in Transition. The Baharvand of Luristan, Iran by Frank Hole and Sekandar Amanolahi-Baharvand

Pastoralism, 2022
Book details Frank Hole and Sekandar Amanolahi-Baharvand Tribal Pastoralists in Transition. The Baharvand of Luristan, Iran Ann Arbor, Michigan: University of Michigan Museum of Anthropology, Anthropological Papers, Number 100; 2021. xx, 381 pages, ISBN:
Richard Tapper
doaj   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

MichiGAN: sampling from disentangled representations of single-cell data using generative adversarial networks

Genome Biology, 2021
Deep generative models such as variational autoencoders (VAEs) and generative adversarial networks (GANs) generate and manipulate high-dimensional images.
Hengshi Yu, Joshua D. Welch
doaj   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Understanding the intersection of race and place: the case of tuberculosis in Michigan

BMC Public Health, 2019
Background Race and place intersect to produce location-based variation in disease distributions. We analyzed the geographic distribution of tuberculosis (TB) incidence in Michigan, USA to better understand the complex interplay between race and place ...
Grace A. Noppert, Philippa Clarke, Margaret T. Hicken, Mark L. Wilson   +3 more
doaj   +1 more source

Correction to: Flexibility in Faculty Work-Life Policies at Medical Schools in the Big Ten Conference: A Ten-Year Follow-up Study by Wagner, et al. Womens Health Rep. 2022; 3:67?77; doi: 10.1089/whr.2021.0070

Women's Health Reports, 2022
In the 2022 issue of Women's Health Reports (vol. 3, no. 1; pp. 67?77), the article entitled ?Flexibility in Faculty Work-Life Policies at Medical Schools in the Big Ten Conference: A Ten-Year Follow-up Study? by Wagner et al. requires correction. There
doaj   +1 more source