Results 11 to 20 of about 5,774 (210)

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

The Natural Product Corramycin Acts as a DNA Gyrase Poison and Overcomes Fluoroquinolone Resistance in Mycobacterium tuberculosis

Advanced Science, EarlyView.
Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...
Franziska Fries, Jennifer Herrmann, Michael Dal Molin, Yaëlle Wormser, Timo Risch, Yunsheng Gao, Gareth Prosser, Francesca Gubellini, Ariel Mechaly, Joshua B. Wallach, Anthony Castro, Arka Banerjee, Sari Rasheed, Alexander Horn, Mathias Müsken, Michael Kurz, Lindsay Sonnenkalb, Viola Dreyer, Stefan Niemann, Sönke Andres, Dirk Schnappinger, Uli Kazmaier, Norbert Reiling, Rolf Müller, Jan Rybniker, Stéphanie Petrella   +25 more
wiley   +1 more source

Metabolism and epigenetics in cancer: toward personalized treatment

Frontiers in Endocrinology
Epigenetic changes, such as DNA methylation, chromatin remodeling, and histone modifications, regulate gene expression without altering the DNA sequence. This review systematically analyzed over 500 studies including human cell line experiments (n>200)
Xiaoman Zhang, Dequan Liu, Sulan Yin, Yaru Gao, Xiaorui Li, Guangzhen Wu   +5 more
doaj   +1 more source

Bacterial Geosmin Biosynthesis is Compartmentalized Inside a Two‐Component Protein Shell

Advanced Science, EarlyView.
This study reports the discovery that geosmin biosynthesis is compartmentalized inside a two‐component protein shell in many bacteria. Sequestration of geosmin synthase inside a Family 2B encapsulin nanocompartment improves geosmin yield and increases enzyme stability as compared to the free enzyme.
Asif Fazal, Cassandra A. Dutcher, Michael P. Andreas, Tobias W. Giessen   +3 more
wiley   +1 more source

Disproportionate Environmental Risks: A Descriptive Analysis of Chemical Facilities and Accidents in the United States

Applied Economic Perspectives and Policy, EarlyView.
ABSTRACT Using nationwide data on the US Environmental Protection Agency's Risk Management Plan (RMP) program, we examine the proportions of underserved populations living near facilities that use extremely hazardous chemicals, both before and after accidents involving fires, explosions, and/or toxic vapors occur.
Karlee Cook, Dennis Guignet, Robin R. Jenkins, Margaret Sugg   +3 more
wiley   +1 more source

Regional Differences in U.S. Consumer Preferences for Native Woody Shrubs With Varying Aesthetic Characteristics

Agribusiness, EarlyView.
ABSTRACT Native plants offer a variety of aesthetic (e.g., fall colour, fruit, flowers) and functional benefits (e.g., pollinator friendly, wildlife friendly, water management). How these benefits influence consumer choice and perceived value of native versus introduced plants is not well understood.
Alicia Rihn, Ariana P. Torres, Sue Barton, Bridget K. Behe   +3 more
wiley   +1 more source

Diverse perspectives, shared goals: harnessing the power of global south science

Perspectives in Ecology and Conservation
The current global scientific landscape is structured as a hierarchy that prioritises Global North epistemologies while treating knowledge from the Global South as peripheral.
L.M. Diele-Viegas, A. Sengupta, F. Dias-Silva, A. Bang, S.A. Lambertucci, L Sravanti, M.A. Aizen, L.E.O. Gomes, T. McIntyre, M.S. Palmer, V.S.S. Praseres, F. Rojas-Marchini, G. Salgado-Garza, S. Sharma, S. Skeen, B.E. Soares, J.S. Souza, S.A. Sousa, D.G. Zanetti, F. Virginio   +19 more
doaj   +1 more source

When the River Runs Low: Heterogeneous Impacts of Transportation Disruptions on Local Grain Basis

Agribusiness, EarlyView.
ABSTRACT A substantial share of U.S. soybean and corn exports from the Midwest moves by barge along the Mississippi River system to export terminals in the Louisiana Gulf. Transportation costs between Midwestern grain elevators and export terminals create a wedge between prices at these locations, and shocks to these costs are partially passed on to ...
Yuan Zhang, Andrew E. Anderson, Nicholas J. Pates, Eunchun Park   +3 more
wiley   +1 more source

Drought Exposure and Dynamic Input Adjustment in North Central U.S. Agriculture

Agribusiness, EarlyView.
ABSTRACT This article examines whether realized extreme drought episodes affect the speed of adjustment of derived input demands and output supplies toward their long‐run equilibrium in U.S. agriculture, focusing on states in the North Central Region.
Victor H. Lana Pinto, Lilyan E. Fulginiti, Richard K. Perrin   +2 more
wiley   +1 more source

Machine learning driven many‐objective moving horizon scheduling optimization

AIChE Journal, EarlyView.
Abstract Industrial electrification can decarbonize chemical manufacturing, but it exposes operations to volatile electricity prices and carbon intensities. This work develops a machine learning‐enhanced many‐objective moving horizon scheduling framework that predicts objective correlation groupings from 48‐hour price and emission‐intensity profiles ...
Hongxuan Wang, Andrew Allman
wiley   +1 more source