Results 51 to 60 of about 1,075,754 (311)
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Micromechanics of creep fracture: simulation of intergranular crack growth [PDF]
, 1998 A computational model is presented to analyze intergranular creep crack growth in a polycrystalline aggregate in a discrete manner and based directly on the underlying physical micromechanisms.
Giessen, Erik van der, +4 more
core +1 more source
FEBS Open Bio, EarlyView.This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel +4 more
wiley +1 more source
, 2008 An assessment of the effects of microstructure on room temperature fatigue crack initiation and short crack propagation in a Ni-base superalloy is presented.
Pang, H.T., Reed, P.A.S.
core +1 more source
Nonlinear dynamics of a rotating shaft with a breathing crack [PDF]
, 2011 In this paper, the effects of a breathing crack on the vibratory characteris- tics of a rotating shaft are investigated. A new, simple and robust model composed of two rigid bars connected with a nonlinear flexural spring is proposed.
Saber El Arem +3 more
core +1 more source
Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina +11 more
wiley +1 more source
The Threshold of Micro Crack Propagation under Mixed Mode
Bulletin of JSME, 1985 In order to investigate the threshold condition of micro fatigue crack propagation under mixed mode, tests of cyclic plane bending, cyclic torsion and their combinations are carried out with a stress ratio R=-l. Annealed cracked specimens made of carbon steel are used in the tests.
KITAOKA, Seiichiro +2 more
openaire +3 more sources
Fatigue crack shielding in plain bearings under large scale yielding
, 2010 Multi-layered bearing systems used in the automotive industry show shielding and antishielding effects that reduce or amplify the crack driving force under large-scale yielding conditions. Using finite element analysis, it is shown that shielding in such
S. Syngellakis +5 more
core +1 more source
Fatigue crack growth behaviour and life prediction for 2324-T39 and 7050-T7451 aluminium alloys under truncated load spectra [PDF]
, 2010 This paper presents a study of crack growth behaviour in aluminium alloys 2324- T39 and 7050-T7451 subjected to flight-by-flight load spectra at different low- stress truncation levels. Crack branching was observed in the higher truncation levels for the
Bao, Rui, Zhang, Xiang
core +1 more source
Advanced Engineering Materials, EarlyView.Predicting extreme defects in additive manufacturing remains a key challenge limiting its structural reliability. This study proposes a statistical framework that integrates Extreme Value Theory with advanced process indicators to explore defect–process relationships and improve the estimation of critical defect sizes. The approach provides a basis for
Muhammad Muteeb Butt +8 more
wiley +1 more source