Results 61 to 70 of about 1,925,273 (264)

A Hybrid Bioprinting–Microfabrication Approach to Controllable Multitype Spheroid Arrays for Modeling Tumor Heterogeneity

Advanced Healthcare Materials, EarlyView.
This work introduces a “cancer‐in‐a‐well” technology that recreates tumor heterogeneity in vitro using multitype spheroid arrays. Combining bioprinting/microdispensing with microstructured culture devices, the system improves drug screening and modeling of tumor complexity.
Simone Bonetti, Eva Clemente, Emanuela Mensà, Marco de Maria, Fulvia Farabegoli, Emanuela Saracino, Barbara Bortolani, Emanuela Marcelli, Renato Brandimarti, Dario de Biase, Giampaolo Zuccheri   +10 more
wiley   +1 more source

Cell‐Free DNA as a Biomarker of Cell Death and Treatment Response for On‐Chip Three‐Dimensional Tumor Models

Advanced Healthcare Materials, EarlyView.
This study presents quantifying cell‐free DNA (cfDNA) as a non‐disruptive and rapidly quantifiable method for assessing cell death for on‐chip 3D sarcoma tumor models. On‐chip cfDNA release reflects tumor burden, extent of cell death, and survival of in vitro and ex vivo 3D models, providing valuable insight into the temporal response of tumor models ...
Maryam Ziaee, Julie Lafontaine, Badr Id Said, Kousha Kamal, Kim Tsoi, Francis Rodier, Thomas Gervais, Philip Wong   +7 more
wiley   +1 more source

MiR-21 nanocapsules promote early bone repair of osteoporotic fractures by stimulating the osteogenic differentiation of bone marrow mesenchymal stem cells

Journal of Orthopaedic Translation, 2020
Objective: The healing of osteoporotic fractures in the elderly patients is a difficult clinical problem. Currently, based on the internal fixation of fractures, the available drug treatments mainly focus on either inhibiting osteoclast function, such as
Xiaolei Sun, Xueping Li, Hongzhao Qi, Xin Hou, Jin Zhao, Xubo Yuan, Xinlong Ma   +6 more
doaj   +1 more source

Can Elastomers Combine Stiffness, Toughness and Fatigue Resistance?

Advanced Materials, EarlyView.
This review studies how the molecular and macroscopic architecture of elastomers influence their mechanical properties including: stiffness, stretchability, toughness, fatigue resistance, and damping behavior. By linking the structure to performance, it proposes design principles for advanced elastomeric systems that combine mechanical properties ...
Eva Baur, Esther Amstad
wiley   +1 more source

Glass Imprint Templates by Spark Assisted Chemical Engraving for Microfabrication by Hot Embossing

Micromachines, 2017
As the field of microelectromechanical systems (MEMS) matures, new demands are being placed on the microfabrication of complex architectures in robust materials, such as hard plastics.
Lucas Abia Hof, Xin Guo, Minseok Seo, Rolf Wüthrich, Jesse Greener   +4 more
doaj   +1 more source

Mould wall friction effects on micro injection moulding based on simulation of MIS

IOP Conference Series: Materials Science and Engineering, 2010
Based on simulation Code MIS, this paper is mainly on the mould wall friction effects to understand more deeply about the flowing behaviour in micro injection moulding. In this study, how the mould wall friction affects the melt flow is demonstrated by comparing the simulation results, between the situation where mould wall friction is considered and ...
Fan Shi, Xiang Zhang, Qian Li, Changyu Shen   +3 more
openaire   +1 more source

Engineering Pluripotent Stem Cells‐Derived Inner Ear Organoids With Enhanced Maturation and Reproducibility by Micro‐Topographical Cues

Advanced Materials, EarlyView.
Micro‐topographical cues applied through temporally controlled microscale confinement improve the reproducibility, spatial organization, and neurosensory‐associated features of pluripotent stem cell‐derived inner ear organoids. Integration with a vascularized organoid platform further enables controlled investigation of vascular‐epithelial interactions
Harshita Sharma, Jungeun Lim, Woochan Kim, Yeon Ju Kim, Dream Kim, Shinyull Lee, Chaeyeon Park, Stephen Rhee, Shruthy Kuttapan, Jungho Ha, Sang Wook Park, Kyunghoon Kim, Noo Li Jeon, Sunho Park, Yun‐Hoon Choung, Jangho Kim   +15 more
wiley   +1 more source

Innovative design and simulation study of a mould for rapid temperature control in micro-injection moulding [PDF]

AIP Conference Proceedings, 2019
Precise temperature control of the mould surface is a key factor for optimising product quality in micro-injection moulding. The ability to rapidly rise or decrease the temperature during the moulding cycle adds further processing benefits including increased productivity, increased freedom of design, and increased quality levels in the finished part ...
De Meo, Annarita, De Santis, Felice, Speranza, Vito, Whiteside, Ben, Coates, Phil D., Pantani, Roberto   +5 more
openaire   +2 more sources

Soft and Transient Bioelectronics Enabled by Polymer‐Free Ti3C2Tx MXene Hydrogels

Advanced Materials, EarlyView.
We present Ti3C2Tx MXene hydrogel (MXgel) bioelectronics, a soft, flexible, and fully transient platform for high‐fidelity neural recording and stimulation. MXgel bioelectronics exhibit exceptional electrical conductivities, low electrochemical impedances, and high charge injection capacities.
Raghav Garg, Franco A. Laimo, Stefano Ippolito, Prastuti Upadhyay, Spencer R. Averbeck, Dimitris Boufidis, Charles‐Antoine Assenmacher, Dayo O. Adewole, Sai Panigrahy, Bita Soltan Mohammadlou, Lucy Plant, Yuan Zhang, Andrew G. Richardson, Yury Gogotsi, D. Kacy Cullen, Flavia Vitale   +15 more
wiley   +1 more source

Femtosecond‐Laser Mould Texturing Enables Tunable Biointerfaces in COC Microfluidics

Advanced Materials Interfaces
Cyclic Olefin Copolymers (COCs) are increasingly used in microfluidic biomedical devices, although their chemically inert surfaces may hamper control of protein adsorption and cell–material interactions.
Irene Varela‐Leniz, Nora Larreategi, Laura Gemini, Taieb Bakouche, Florent Husson, Leire Gartzia‐Rivero, Eider Bilbao Castellanos, Ane Miren Zaldua, José Luis Vilas‐Vilela, Leire Etxeberria   +9 more
doaj   +1 more source