Results 41 to 50 of about 1,055,028 (267)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Strategic Responses in the COVID-19 Period: A Study of Selected Micro, Small and Medium Enterprises in the Western Cape

Businesses
The COVID-19 pandemic devastated businesses globally, leading to significant economic and social challenges. Micro, Small and Medium Enterprises (MSMEs) are particularly vulnerable to environmental turbulence, while their survival and resilience are ...
Fungai Chiruka, Zivanayi Mazhazha-Nyandoro, Renier Grosch, Ntandoyenkosi Sibindi   +3 more
doaj   +1 more source

Estimating Factors Affecting Technical Efficiency in Indian Manufacturing Sector [PDF]

Eurasian Journal of Business and Economics, 2019
Existing studies could not estimate the technical efficiency (TE) of firms and it’s affecting factors in the Indian manufacturing sector. So, the present study examines the TE of firms using a stochastic frontier production function approach.
Ajay Kumar SINGH, Shah Nawaz ASHRAF, Ashish ARYA   +2 more
doaj   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Micro, small, and medium enterprises (MSMEs) and poverty reduction: empirical evidence from Indonesia

Development Studies Research, 2020
This study aims to analyze the effect of MSMEs on poverty reduction, both directly and indirectly, through labor absorption from 1997 to 2018. The poverty measurements used in this study comprise Head Count Index (P0), Poverty Gap Index (P1), and Poverty
Nursini Nursini
doaj   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Influence of the nano-micro structure of the surface on bacterial adhesion

Materials Research, 2007
Biomaterials failures are frequently associated to the formation of bacterial biofilms on the surface. The aim of this work is to study the adhesion of non motile bacteria streptococci consortium and motile Pseudomonas fluorescens.
Carolina Díaz, María Cecilia Cortizo, Patricia Laura Schilardi, Sandra Gabriela Gómez de Saravia, Mónica Alicia Fernández Lorenzo de Mele   +4 more
doaj   +1 more source

Portrait of MSMEs‘ Islamic Financial Literacy and The Impact on Business Development

Afkaruna: Indonesian Interdisciplinary Journal of Islamic Studies, 2022
MSMEs are part of the supporting aspects of the country's economy. However, the competitiveness of MSMEs in Indonesia towards the global economy still tends to be low when compared to other ASEAN countries.
Aqidah Asri Suwarsi, Aninta Gina Sharfina, Anisatun Anggraeni   +2 more
doaj   +1 more source

The Micro Design of Micro-Lecture [PDF]

Advances in Computer Science Research, 2015
This paper on the introduction of the concept, significance and application of Micro-Lecture model, based on the proposed micro course design should stick to flip the classroom education connotation and the characteristics of micro class resources, fully grasp and use micro class design series micro strategies, including: micro perspective of topic ...
openaire   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source