Decoding Human Placental Cellular and Molecular Responses to Obesity and Fetal Growth
Advanced Science, EarlyView.Women with obesity often deliver large‐for‐gestational‐age (LGA) infants. Single‐nucleus RNA sequencing of term placenta reveals that hypoxia and TNF‐α signaling in syncytiotrophoblasts are featured in maternal obesity, but inflammatory signatures in Hofbauer cells and response to lipid or carbohydrate metabolism in fibroblasts are specific to LGA.
Hong Jiang +12 more
wiley +1 more source
Enablers and Barriers to Alternative Care: Perspectives of Community-Dwelling Older Adults and Service Providers in Kerala. [PDF]
Health ExpectMohan A, Jothikaran TAJ, Ashok L.
europepmc +1 more source
A Review on Biodegradable Materials of Sustainable Soft Robotics and Electronics
Advanced Science, EarlyView.Biodegradable materials are gaining increasing attention in soft robotics and electronics due to their environmental friendliness, showing great potential for sustainability. In this review, the classification of biodegradable materials, their applications in the field of soft robotics and electronics, as well as the challenges and future prospects ...
Yizhu Xie +8 more
wiley +1 more source
Advanced Science, EarlyView.This study demonstrates that dual UCP2/IL‐17 blockade reprograms T‐cell metabolism to overcome PDAC immunosuppression. Genipin‐mediated UCP2 inhibition enhances CD8⁺ T‐cell IFN‐γ via IL‐12R/STAT4/mTOR signaling and mitochondrial OXPHOS. Combined IL‐17 depletion amplifies Tc1/Th1 responses, reduces MDSCs, and prolongs survival in PDAC models ...
Chuan‐Teng Liu +11 more
wiley +1 more source
Microstructure Evolution Study of the Field-Serviced Silicone Rubber Insulator via X-Ray Micro-CT Imaging. [PDF]
Polymers (Basel)Chen T +5 more
europepmc +1 more source
Atomistic Understanding of 2D Monatomic Phase‐Change Material for Non‐Volatile Optical Applications
Advanced Science, EarlyView.Antimony is a promising monatomic phase‐change material. Scaling down the film thickness is necessary to prolong the amorphous‐state lifetime, but it alters the optical properties. The combined computational and experimental study shows that, as thickness decreases, the extinction coefficient and optical contrast are reduced in the near‐infrared ...
Hanyi Zhang +10 more
wiley +1 more source
Moving forward, leaving the patients behind? A multilevel assessment framework for evaluating patient-centred, integrated care quality. [PDF]
Qual Life ResCassidy S +4 more
europepmc +1 more source
PEDOT:PSS—A Key Material for Bioelectronics
Advanced Science, EarlyView.PEDOT:PSS ‐ Poly(3,4‐ethylenedioxythiophene) polystyrene sulfonate ‐ is typically processed from water dispersions to form multifunctional and multidimensional constructs with tunable electronic and ionic conductivity. Throught processing engineering, PEDOT:PSS is intergrated in bioelectronic devices that operate efficiently in physiological conditions
Alan Eduardo Ávila Ramírez +5 more
wiley +1 more source
Micro-Hotplate for Thermocatalytic Gas Sensor Fabricated by Ceramic Laser Micromachining. [PDF]
Micromachines (Basel)Samotaev N +6 more
europepmc +1 more source
Advanced Science, EarlyView.A microfluidic electrochemical biosensor enables sensitive and specific detection of antibodies associated with vaccine‐induced immune thrombotic thrombocytopenia (VITT) and heparin‐induced thrombocytopenia (HIT). The platform uses two antigen targets— platelet factor 4 (PF4) and cross‐linked‐PF4 (c‐PF4)—and microliter volumes of patient sera to ...
Diana F. Cedillo‐Alcantar +8 more
wiley +1 more source