Results 101 to 110 of about 76,606 (312)

The biology of PKM2 in the metabolism and senescence in diabetic kidney disease

Journal of Diabetes Investigation, EarlyView.
ABSTRACT Diabetic kidney disease (DKD) is one of the most common causes of chronic kidney disease that leads to end‐stage kidney disease, and its progression is closely linked to metabolic stress within renal tubular cells. Under long‐term hyperglycemia, cells shift their glucose metabolism from normal oxidative phosphorylation toward glycolysis.
Md. Imrul Kayes, Keizo Kanasaki
wiley   +1 more source

The Relation between Microalbuminuria and Helicobacter Pylori VacA Gene in Type 2 Diabetic Patients, Isfahan, Iran

مجله دانشکده پزشکی اصفهان, 2012
Background: Diabetes mellitus is the most prevalent metabolic disorder worldwide with many subsequent medical complications. An important complication of diabetes is microalbuminuria which is a major indication for development of diabetic nephropathy ...
Latifeh Abdollahi, Mohammad Reza Zolfaghari, Masoud Amini, Rasoul Salehi   +3 more
doaj  

Study of microalbuminuria and its correlation with glycaemic status in type 2 diabetes mellitus

MRIMS Journal of Health Sciences, 2016
Background: It is well established that diabetic nephropathy is a dreaded complication of Type 2 diabetes mellitus. However in the early stages; also known as incipient nephropathy, it can be detected by the presence of microalbuminuria.
K Srjana, P Amith Kumar
doaj   +1 more source

The role of zinc in renal pathological changes in diabetic status [PDF]

, 2015
Diabetes mellitus (DM) was the 8th leading cause of death in 2011, resulting in 1.4 million deaths worldwide. One of the complications of DM is chronic kidney disease, which accounts for nearly 44% of all new cases of kidney failure in the US in 2011 ...
Fernando, Julie, Zhou, Shaobo
core   +1 more source

Early Progressive Renal Decline Precedes the Onset of Microalbuminuria and Its Progression to Macroalbuminuria

Diabetes Care, 2013
OBJECTIVE Progressive decrease in the glomerular filtration rate (GFR), or renal decline, in type 1 diabetes (T1D) is observed in patients with macroalbuminuria.
A. Krolewski, M. Niewczas, J. Skupień, Tomhito Gohda, A. Smiles, J. Eckfeldt, A. Doria, J. Warram   +7 more
semanticscholar   +1 more source

mTOR blockade prevents progressive proteinuria but induces hyperglycaemia in obese Dahl salt‐sensitive rats before puberty

Experimental Physiology, EarlyView.
Abstract Previous studies have demonstrated that mammalian target of rapamycin (mTOR) activity is significantly increased in the kidneys of Dahl salt‐sensitive (SS) rats during the development of renal injury. Therefore, in the present study we examined whether blockade of mTOR with rapamycin inhibits renal injury in Dahl salt‐sensitive leptin receptor
Sautan Mandal, Andrea K. Brown, Ubong S. Ekperikpe, Anukool A. Bhopatkar, Krystle M. Hughes, Tyler D. Johnson, Jonita S. Cooper, Konnor T. Wilbert, Denise C. Cornelius, Jan M. Williams   +9 more
wiley   +1 more source

Beyond BMI: Practical Guide for Clinicians to Integrate the Lancet Commission's Obesity Framework and King's Obesity Staging System

Clinical Obesity, Volume 16, Issue 1, February 2026.
ABSTRACT Body mass index (BMI) on its own is a poor diagnostic and staging tool for obesity because it does not measure health status. The newly published Lancet Clinical Obesity Criteria (LCOC) for defining clinical obesity distinguish preclinical and clinical obesity based on organ or tissue dysfunction.
Tak Ying Louise Ko, Alexander D. Miras, Dimitri J. Pournaras, Carel W. Le Roux   +3 more
wiley   +1 more source

An Observational Study on the Association Between Surrogates of Visceral Adiposity and Albuminuria in Type 2 Diabetes

Clinical Diabetology
OBJECTIVE: This study aimed to investigate the associations between albuminuria and visceral adiposity in patients with type 2 diabetes (T2D). MATERIALS AND METHODS: This single-center crosssectional study included patients with T2D.
Ümmügülsüm Durak, Miraç Vural Keskinler, Gunes Alkaya Feyizoglu, Furkan Durak, Cundullah Torun, Tahsin Karaaslan, Aytekin Oğuz   +6 more
doaj   +1 more source

Liraglutide and renal outcomes in type 2 diabetes [PDF]

, 2017
In a randomized, controlled trial that compared liraglutide, a glucagon-like peptide 1 analogue, with placebo in patients with type 2 diabetes and high cardiovascular risk who were receiving usual care, we found that liraglutide resulted in lower risks ...
Brown-Frandsen, Kirstine, Buse, John B., Mann, Johannes F. E, Maranghi, M., Marso, Steven P, Poulter, Neil R, Rasmussen, Søren, Tornøe, Karen, Zinman, Bernard, Ørsted, David D   +9 more
core   +2 more sources

The impact of obesity on pregnancy outcomes in women with type 1 and type 2 diabetes across the NSW population: A retrospective cohort study

Diabetic Medicine, Volume 43, Issue 2, February 2026.
Abstract Aims To examine differences in pregnancy outcomes between women with type 1 (T1D) and type 2 diabetes (T2D) and assess the impact of concurrent obesity on adverse perinatal outcomes. Materials and Methods We retrospectively analysed singleton births of nulliparous mothers with T1D and T2D from 2016 to 2020, in New South Wales, Australia.
Xavier Rickard, Matilda S. G. Longfield, Jackson Zhou, Ibinabo Ibiebele, Tessa Weir, Deborah Randall, Siranda Torvaldsen, Felicity Gallimore, Jonathan Morris, Tanya Nippita, Sarah J. Glastras   +10 more
wiley   +1 more source