Results 121 to 130 of about 185,542 (303)

BABAR: an R package to simplify the normalisation of common reference design microarray-based transcriptomic datasets

BMC Bioinformatics, 2010
Background The development of DNA microarrays has facilitated the generation of hundreds of thousands of transcriptomic datasets. The use of a common reference microarray design allows existing transcriptomic data to be readily compared and re-analysed ...
Hinton Jay CD, Seers John, Alston Mark J, Lucchini Sacha   +3 more
doaj   +1 more source

Multi-modal optical microscopy image analysis and matching techniques for spatially encoded bead-based microarrays [PDF]

, 2017
Abhik Datta
openalex   +1 more source

Heterogeneity Landscape of Circulating Tumor Cells in Clinical Utility

Advanced Therapeutics, EarlyView.
This study reports the heterogeneity spectrum of circulating tumor cells. The factors involved in the spectrum promote CTCs to overcome barriers in the metastatic cascade but impact the clinical outcome of cancer patients. In summary, the heterogeneities in association with CTCs ultimately reduce patient survival and facilitate increasing mortality of ...
Md Kowsar Alam, Lu Yanjun, Bee Luan Khoo, Tongxu Si, Heng Zou, Mengsu Yang   +5 more
wiley   +1 more source

Microphysiological Systems in Cancer Research: Advancing Immunotherapy through Tumor Microenvironment‐Integrated Organ‐On‐Chip Models

Advanced Therapeutics, EarlyView.
Emerging microphysiological systems reproduce the spatial, biochemical, and cellular complexity of the tumor microenvironment, surpassing 2D cultures and murine models. By integrating patient‐derived tumors, perfusable vasculature, and immune trafficking, these organ‐on‐chip platforms reveal mechanisms of immune evasion, predict therapeutic responses ...
Fabiana Moresi, Francesco Noto, Jyothsna Vasudevan, Xavier Bisteau, Giulia Adriani, Andrea Pavesi   +5 more
wiley   +1 more source

Enhancement of Classifier Performance with Adam and RanAdam Hyper-Parameter Tuning for Lung Cancer Detection from Microarray Data—In Pursuit of Precision

Bioengineering
Microarray gene expression analysis is a powerful technique used in cancer classification and research to identify and understand gene expression patterns that can differentiate between different cancer types, subtypes, and stages.
Karthika M S, Harikumar Rajaguru, Ajin R. Nair   +2 more
doaj   +1 more source

Unsupervised technique for robust target separation and analysis of DNA microarray spots through adaptive pixel clustering [PDF]

, 2002
Daniel Bozinov, Jörg Rahnenführer
openalex   +1 more source

SMYD3 Promotes Immune Evasion in Clear Cell Renal Cell Carcinoma via SREBP1‐Mediated Transactivation of CD47

Advanced Science, EarlyView.
Cancer cell‐intrinsic SMYD3 orchestrates an immunosuppressive microenvironment and impairs the response to PD‐1 blockade by reprogramming immune cells landscape in the tumor microenvironment of clear cell renal cell carcinoma (ccRCC). The immunomodulatory function of SMYD3 is mediated via the SREBP1/CD47 pathway.
Zhengfang Liu, Xiumei Zhao, Maolin Zang, Huiyang Yuan, Xin Qin, Xiaofeng Li, Shuo Zhao, Ruirong Tan, Keqiang Yan, Li Liu, Yidong Fan, Ning Zhang, Benkang Shi, Bo Han, Shouzhen Chen   +14 more
wiley   +1 more source

Clinical profile and cytogenetics of siblings with Jacobsen syndrome

Journal of Current Research in Scientific Medicine
The clinical care of patients has greatly benefited from the advancement of genetic testing. Over time, a gradual move toward a “genotype-first” strategy and growing use of genome-wide testing techniques such as chromosomal microarray analysis and next ...
Abinaya Gunalan, Priya Jose, Allen David, Peter Prasanth Kumar Kommu   +3 more
doaj   +1 more source

ST6GAL1‐Mediated Sialylation Stabilizes PD‐L1 and Drives Immunosuppressive Tumor Microenvironment in Colorectal Cancer

Advanced Science, EarlyView.
ST6GAL1 plays a critical role in tumor progression and immune regulation in colorectal cancer (CRC). Its depletion significantly suppresses the malignant phenotype of CRC cells and enhances the efficacy of anti‐PD‐L1 therapy. High ST6GAL1 expression promotes an immune‐activated tumor microenvironment (TME), characterized by increased infiltration of ...
Ximo Xu, Jingyi Liu, Wei Qin, Chengsheng Ding, Zhenghao Cai, Duohuo Shu, Hao Zhong, Yanyan Hu, Mengqin Yu, Leqi Zhou, Jianwen Li, Minhua Zheng, Bin Li, Sen Zhang, Xiao Yang, Bo Feng   +15 more
wiley   +1 more source

Towards the integration of computational systems biology and high-throughput data: supporting differential analysis of microarray gene expression data

Journal of Integrative Bioinformatics, 2008
The paradigmatic shift occurred in biology that led first to high-throughput experimental techniques and later to computational systems biology must be applied also to the analysis paradigm of the relation between local models and data to obtain an ...
Segata Nicola, Blanzieri Enrico, Priami Corrado   +2 more
doaj   +1 more source