Results 161 to 170 of about 180,353 (259)

Hijacking the MDM2 E3 Ligase with novel BRD4‐Targeting PROTACs in Pancreatic Cancer Cells

ChemBioChem, Accepted Article.
The phenotypic effect induced by a Proteolysis‐Targeting Chimera (PROTAC) can depend on several factors, including the E3 ligase recruited. For the discovery of a first‐in‐class PROTAC for a target of interest, the E3 ligases commonly hijacked remain the Von Hippel‐Lindau (VHL) and Cereblon (CRBN) since potent and accessible ligands are readily ...
Mihaela Ficu, Dan Niculescu-Duvaz, Mohammed Aljarah, Caroline Springer, Christopher S. Kershaw   +4 more
wiley   +1 more source

Integration of Microarray and Single-Cell RNA-Seq Data and Machine Learning Allows the Identification of Key Histone Modification Gene Changes in Spermatogonial Stem Cells. [PDF]

Biology (Basel)
Shakeri Abroudi A, Azizi H, Djamali M, Qorbanee A, Skutella T.   +4 more
europepmc   +1 more source

Development and Recent Advances in SLIPT‐PM: A Chemogenetic Platform for Manipulating Signaling at the Plasma Membrane

ChemBioChem, Accepted Article.
Upon cell stimulation, mammalian cells activate various signaling proteins and lipids by recruiting their upstream regulators to the inner leaflet of the plasma membrane (PM), which in turn determines their cellular response. Therefore, artificially inducing protein translocation to the PM is an effective strategy for dissecting cell signaling networks
Shuya Ohira, Akinobu Nakamura, Kenta Terai, Shinya Tsukiji   +3 more
wiley   +1 more source

Whole genome uniparental isodisomy detected using single nucleotide polymorphism (SNP) microarray in molar pregnancy: a case report. [PDF]

Mol Cytogenet
Okonkwo OO, Ortega V, Kane S, Aldrete G, Ramirez P, Valente PT, Velagaleti GVN.   +6 more
europepmc   +1 more source

Contemporary Perspectives on Chronic Renal Disorders

Chronic Diseases and Translational Medicine, EarlyView.
ABSTRACT The prevalence of renal diseases and its associated burden on healthcare have tremendously risen in the past few years. From simple markers assessing kidney function, current renal research delves into understanding the diseases at the cellular and molecular levels and not just at treating, but at improving quality of life, arresting ...
Deenadhayalan Ashok, Poornima Ajay Manjrekar, Bhushan C. Shetty, Sujina S. S, Rukmini Mysore Srikantiah, Sowndarya Kollampare   +5 more
wiley   +1 more source

Machine learning identifies genes linked to neurological disorders induced by equine encephalitis viruses, traumatic brain injuries, and organophosphorus nerve agents. [PDF]

Front Comput Neurosci
Yin L, VanderGiessen M, Kumar V, Conacher B, Chao PH, Theus M, Johnson E, Kehn-Hall K, Wu X, Xie H.   +9 more
europepmc   +1 more source

Detection of C‐Reactive Protein by Electrochemiluminescence‐Based Droplet‐Free Digital Immunoassay with Tyramide Signal Amplification

ChemElectroChem, EarlyView.
C‐reactive protein (CRP) is an essential biomarker for monitoring inflammation and disease progression. This study presents a droplet‐free digital immunoassay system using electrochemiluminescence imaging for sensitive CRP detection. Utilizing tyramide signal amplification, the system achieves precise single‐particle quantification without droplet ...
Hiroya Abe, Shuri Nakamura, Kentaro Ito, Kosuke Ino, Zhengyi Liu, Shinichi Sato, Kumi Y. Inoue, Hitoshi Shiku   +7 more
wiley   +1 more source

Heterogeneity-preserving discriminative feature selection for disease-specific subtype discovery. [PDF]

Nat Commun
M A Basher AR, Hallinan C, Lee K.
europepmc   +1 more source

Comprehensive DSRCT multi‐omics analyses unveil CACNA2D2 as a diagnostic hallmark and super‐enhancer‐driven EWSR1::WT1 signature gene

Cancer Communications, EarlyView.
Florian Henning Geyer, Alina Ritter, Seneca Kinn‐Gurzo, Tobias Faehling, Jing Li, Armin Jarosch, Carine Ngo, Endrit Vinca, Karim Aljakouch, Azhar Orynbek, Shunya Ohmura, Thomas Kirchner, Roland Imle, Laura Romero‐Pérez, Juan Díaz‐Martín, Stefanie Bertram, Enrique de Álava, Clémence Henon, Sophie Postel‐Vilnay, Ana Banito, Martin Sill, Yvonne Versleijen‐Jonkers, Benjamin Friedrich Berthold Mayer, Martin Ebinger, Monika Sparber‐Sauer, Sabine Stegmaier, Daniel Baumhoer, Wolfgang Hartmann, Jeroen Krijgsveld, David Horst, Olivier Delattre, Patrick Joseph Grohar, Thomas Georg Phillip Grünewald, Florencia Cidre‐Aranaz   +33 more
wiley   +1 more source

Enhancing Cancerous Gene Selection and Classification for High-Dimensional Microarray Data Using a Novel Hybrid Filter and Differential Evolutionary Feature Selection. [PDF]

Cancers (Basel)
Hashmi A, Ali W, Abulfaraj A, Binzagr F, Alkayal E.   +4 more
europepmc   +1 more source