Results 171 to 180 of about 361,751 (317)

Transcription Factor Promiscuity Drives Regulatory Rewiring and Evolvability in Gene Networks in Bacteria

Advanced Science, EarlyView.
When a master transcription factor (TF) is lost, bacteria can rapidly rewire gene regulatory networks by co‐opting related regulators. Using experimental evolution in Pseudomonas fluorescens, we show that TF promiscuity (low‐level, non‐cognate binding) provides the raw material for rewiring. Successful co‐option follows a predictable hierarchy governed
Tiffany B. Taylor, Alan M. Rice
wiley   +1 more source

Microbial Diversity of Spontaneously Fermented Camel Milk. [PDF]

Foods
Abaalkhail MA, Mohamed SHS, Aljurbua MS, Alkhuraisi RA, Aladhadh M.   +4 more
europepmc   +1 more source

Macrophage Extracellular Traps in Immunity and Cancer

Advanced Science, EarlyView.
As a macrophage‐mediated innate defense mechanism, the dysregulated release of METs drives chronic inflammation and influences tumor progression. Furthermore, METs exhibit a functional duality within the tumor microenvironment, capable of both promoting and suppressing tumor development.
Junyao Li, Eugenie Nepovimova, Adam Grundel, Lukas Peter, Qinghua Wu, Kamil Kuca   +5 more
wiley   +1 more source

From microbial diversity to functional potential using dimensionality reduction. [PDF]

Front Microbiol
Chamberlain EJ, Boulton W, Connors E, Calianos T, Bowman JS, Creamean JM, Mock T, Kim HH.   +7 more
europepmc   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Investigating the Physiological and Metabolic Requirements of the Tramway Ridge Microbial Community, Mt Erebus, Antarctica

, 2012
Mount Erebus is the most active volcano on the Antarctic continent, and has the most geographically and physically isolated geothermal soil on Earth. It is exposed to some of the most extreme environmental conditions on the planet.
Vickers, Chelsea Joy
core  

Warm-Water Regimes Influence Microbial Diversity and Ecological Functions in Subtropical Gulf. [PDF]

Ecol Evol
He Q, Huang L, Huang C, Nethmini RT, Ferdoush J, Zhou S, Jiang G, Hou Q, Li X, Chen Q, Dong K, Xie L, Li N.   +12 more
europepmc   +1 more source

Leveraging Macrophage Metabolic Reprogramming for Enhanced Anti‐Tumor Immunity

Advanced Science, EarlyView.
Tumor‐associated macrophages (TAMs) are key regulators of the tumor microenvironment (TME), with their metabolic states playing a critical role in tumor progression or regression. This review summarizes current understanding of TAM metabolic plasticity alongside cutting‐edge bioengineering innovations, outlining a roadmap for transforming the ...
Zhiyun Liu, Lingyao Zeng, Xulin Gan, Yilin Zhou, Han Shen, Dan Wu, Xin Shou, Minmin Jiang, Liyun Shi   +8 more
wiley   +1 more source

Is apical periodontitis a matter of microbial diversity or time? A scoping review. [PDF]

Head Face Med
Nazir SM, Saied SMM, Eskander ME, Mansour MM, Abdelrahman H, Elbackly RM, Elnawam HM.   +6 more
europepmc   +1 more source

Enzymatic DNA Reaction Networks for Orchestrating Stimuli‐Dependent Temporal Molecular Pulse

Advanced Science, EarlyView.
We present an enzymatic DNA reaction network (EDRN) that encodes nucleic‐acid targets in time, converting inputs into a universal strand and then into programmable transient fluorescence pulses. With time‐color multiplexing, EDRN enables single‐tube high‐plex nucleic acid detection and shows strong agreement with clinical sequencing across 32 specimens.
Jiayu Yang, Yali Chang, Zibin Chu, Linghao Zhang, Tengfang Zhang, Dai Erhei, Xin Su, Zhe Yin   +7 more
wiley   +1 more source