Results 81 to 90 of about 652,986 (356)

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

FEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima, Shogo Okazaki, Muneaki Tamura, Shuichi Sato, Kenichi Imai   +4 more
wiley   +1 more source

Cultivation of Mushrooms and Their Lignocellulolytic Enzyme Production Through the Utilization of Agro-Industrial Waste

Molecules, 2020
A large amount of agro-industrial waste is produced worldwide in various agricultural sectors and by different food industries. The disposal and burning of this waste have created major global environmental problems. Agro-industrial waste mainly consists
Jaturong Kumla, Nakarin Suwannarach, Kanaporn Sujarit, Watsana Penkhrue, Pattana Kakumyan, Kritsana Jatuwong, Santhiti Vadthanarat, Saisamorn Lumyong   +7 more
doaj   +1 more source

Chemical Impacts of the Microbiome Across Scales Reveal Novel Conjugated Bile Acids [PDF]

, 2019
A mosaic of cross-phyla chemical interactions occurs between all metazoans and their microbiomes. In humans, the gut harbors the heaviest microbial load, but many organs, particularly those with a mucosal surface, associate with highly adapted and ...
Mazmanian, Sarkis, Quinn, Robert A., Thron, Taren   +2 more
core  

Microbial diversity arising from thermodynamic constraints [PDF]

, 2016
The microbial world displays an immense taxonomic diversity. This diversity is manifested also in a multitude of metabolic pathways that can utilize different substrates and produce different products.
A Flamholz, B Kerr, B Schink, B Schink, CY Hoh, G Hardin, GE Hutchins, H Seitz, HF Cueto-Rojas, I Gudelj, J Bunge, J Dolfing, J Monod, J Rodríguez, MJ De Freitas, Orkun S Soyer, Q Jin, Q Jin, R Conrad, R González-Cabaleiro, R Kleerebezem, R Lenski, RC MacLean, RK Thauer, S Gupta, S O’Brien, SB Hsu, T Großkopf, T Pfeiffer, Tobias Großkopf, TP Curtis, Y Gan   +31 more
core   +1 more source

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

FEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

A Unique THN Motif Is Critical for Enabling Efficient C‐Terminal Traceless Cleavage

Advanced Science
Traceless protein cleavage is a significant challenge in intein application, as most common inteins studied today are not both active and promiscuous.
Ruocheng Gu, Yunuo Lin, Rouyu Di, Tongtong Zhou, Tingwen Fan, Wei Li, Lili Miao, Huaiyi Yang   +7 more
doaj   +1 more source

Nutrient levels and trade-offs control diversity in a serial dilution ecosystem

, 2020
Microbial communities feature an immense diversity of species and this diversity is linked with outcomes ranging from ecosystem stability to medical prognoses. Yet the mechanisms underlying microbial diversity are under debate.
Abel, Abrams, Adler, Aldén, Armstrong, Barton, Basan, Bernstein, Bienhold, Brown,, Chang, Chesson, Chesson, Dakos, Demoling, Egli, Erez, Flourie, Goldford, Goyal, Hubbell, Hutchinson, Jost, Kassen, Kelsic, Kim, Kovárová-Kovar, Ladau, Leibold, Lendenmann, Lendenmann, Lendenmann, Lenski, Levin, Lloyd-Price, MacArthur, Mittelbach, Monod, Murrell, Münster, Palmer, Posfai, Ptacnik, Robinson, Rosenzweig, Scherer, Scott, Smith, Smith, Smits, Stein, Stewart, Taur, Thingstad, Tilman, Tilman, van Elsas, Waide, Wandrey, Weigel, Wortel, Yurtsev   +61 more
core   +1 more source

Controls on development and diversity of Early Archean stromatolites [PDF]

, 2009
The ≈3,450-million-year-old Strelley Pool Formation in Western Australia contains a reef-like assembly of laminated sedimentary accretion structures (stromatolites) that have macroscale characteristics suggestive of biological influence.
A. C. Allwood, A. H. Knoll, Fenchel, Grotzinger, I. Kanik, I. W. Burch, J. P. Grotzinger, Knoll, M. L. Coleman, M. S. Anderson, Schopf, Schopf   +11 more
core   +3 more sources

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Engineering Methylotrophic Yeasts as Cell Factories for Chemical Production Using Methanol as a Feedstock

GCB Bioenergy
Methanol, a sustainable and abundant one‐carbon (C1) feedstock, has emerged as a promising raw material for green biomanufacturing, offering a pathway to carbon neutrality. Natural methylotrophic yeasts such as Pichia pastoris (syn. Komagataella phaffii)
Shuxian Wang, Jiayu Fang, Yanping Zhang, Yin Li, Taicheng Zhu   +4 more
doaj   +1 more source