Evolution of Prime Editing: Enhancing Efficiency and Expanding Capacity
Advanced Science, EarlyView.Most rare diseases are caused by genetic mutations. Prime editing (PE) has emerged as a versatile tool capable of inducing diverse mutations without generating DNA double‐strand breaks. Despite its significant clinical potential, PE faces limitations in terms of efficiency and scalability.
Jihyeon Yu +5 more
wiley +1 more source
Microbial eukaryotes in the human microbiome: ecology, evolution, and future directions
Frontiers in Cellular and Infection Microbiology, 2011 High throughput sequencing technology has opened a window into the vast communities of bacteria that live on and in humans, demonstrating tremendous variability and that they play a large role in health and disease. The eukaryotic component of the human
Laura eWegener Parfrey +3 more
doaj +1 more source
Micro-eukaryotic diversity in hypolithons from Miers Valley, Antarctica [PDF]
, 2013 The discovery of extensive and complex hypolithic communities in both cold and hot deserts has raised many questions regarding their ecology, biodiversity and relevance in terms of regional productivity.
Cary, S. Craig +4 more
core +5 more sources
Programming Next‐Generation Synthetic Biosensors by Genetic Circuit Design
Advanced Science, EarlyView.Synthetic biology enables genetic circuit‐based biosensing to detect diverse targets, process signals, and transduce them into readable outputs or intracellular regulatory activities. However, field deployment and real‐world application of such synthetic biosensors face considerable challenges in sensitivity, specificity, speed, stability, and ...
Yuanli Gao +4 more
wiley +1 more source
Stable dominance of parasitic dinoflagellates in Antarctic sponges [PDF]
PeerJBackground Marine sponges are dominant components of Antarctic benthos and representative of the high endemism that characterizes this environment. All microbial groups are part of the Antarctic sponge holobionts, but microbial eukaryotes have been ...
Marileyxis R. López-Rodríguez +5 more
doaj +2 more sources
Dating the cyanobacterial ancestor of the chloroplast [PDF]
, 2009 Cyanobacteria have played a pivotal role in the history of life on Earth being the first organism to carry out oxygenic photosynthesis, which changed atmospheric chemistry and allowed the evolution of Eukarya.
Amanda Castillo +2 more
core +1 more source
Metaxa : a software tool for automated detection and discrimination among ribosomal small subunit (12S/16S/18S) sequences of archaea, bacteria, eukaryotes, mitochondria, and chloroplasts in metagenomes and environmental sequencing datasets [PDF]
, 2011 Peer ...
Abarenkov, Kessy +9 more
core +1 more source
Advanced Science, EarlyView.Soybean production is severely threatened by salt stress. This study reveals that the GmSIN1‐GmRNF1a‐GmCSN5a module enhances salt tolerance by stabilizing the GmSIN1 protein. GmRNF1a acts as an E3 ligase to ubiquitinate GmSIN1 for degradation, a process inhibited by GmCSN5a.
Jinlong Xu +15 more
wiley +1 more source
The Biogeography of Apicomplexan Parasites in Tropical Soils
Ecology and EvolutionParasitic protists such as Apicomplexa, an abundant group of soil protists, contribute to ecosystem processes and nutrient cycling in belowground soil systems through their obligate symbioses with soil Metazoa.
Rachel M. Shepherd, Angela M. Oliverio
doaj +1 more source
Microbiology SpectrumPhytoplankton are important drivers of aquatic ecosystem function and environmental health. Their community compositions and distributions are directly impacted by environmental processes and human activities, including in the largest estuary in North ...
Hualong Wang +6 more
doaj +1 more source