Results 71 to 80 of about 3,263,643 (290)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Synthetic microbial communities [PDF]

, 2014
While natural microbial communities are composed of a mix of microbes with often unknown functions, the construction of synthetic microbial communities allows for the generation of defined systems with reduced complexity.
Soyer, Orkun S, Soyer, Orkun S., Großkopf, Tobias   +2 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Baltic Sea coastal sediment-bound eukaryotes have increased year-round activities under predicted climate change related warming

Frontiers in Microbiology
Climate change related warming is a serious environmental problem attributed to anthropogenic activities, causing ocean water temperatures to rise in the coastal marine ecosystem since the last century.
Songjun Li, Emelie Nilsson, Laura Seidel, Laura Seidel, Marcelo Ketzer, Anders Forsman, Mark Dopson, Samuel Hylander   +7 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Microbial Communities and Electrochemical Performance of Titanium-Based Anodic Electrodes in a Microbial Fuel Cell [PDF]

, 2011
Four types of titanium (Ti)-based electrodes were tested in the same microbial fuel cell (MFC) anodic compartment. Their electrochemical performances and the dominant microbial communities of the electrode biofilms were compared.
Heijne, Annemiek ter,, Hamelers, Hubertus V.M.,, Stams, Alfons J.M.,, Michaelidou, Urania,, ter Heijne, A., Euverink, Gerrit Jan W.,, Euverink, G., Hamelers, H., Urania Michaelidou, Heijne, A., ter, Euverink, G.J.W., Hamelers, H.V.M., Michaelidou, U., Geelhoed, Jeanine S.,, Geelhoed, J.S., Alfons J. M. Stams, Geelhoed, J., Annemiek ter Heijne, Stams, A.J.M., Stams, A., Gerrit Jan W. Euverink, Hubertus V. M. Hamelers, Jeanine S. Geelhoed   +22 more
core   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Population genetic structure, differentiation, and diversity in Tetrix subulata pygmy grasshoppers: roles of population size and immigration

Ecology and Evolution, 2016
Genetic diversity within and among populations and species is influenced by complex demographic and evolutionary processes. Despite extensive research, there is no consensus regarding how landscape structure, spatial distribution, gene flow, and ...
Jon Tinnert, Olof Hellgren, Jenny Lindberg, Per Koch‐Schmidt, Anders Forsman   +4 more
doaj   +1 more source

Microbial evolution-An under-appreciated driver of soil carbon cycling

International audienceAbstract Although substantial advances in predicting the ecological impacts of global change have been made, predictions of the evolutionary impacts have lagged behind.
Chase, Alexander, B, Abs, Elsa, Ciais, Philippe, Manzoni, Stefano, Allison, Steven, D   +4 more
core   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source