Results 31 to 40 of about 294,401 (183)

Improved Network Performance via Antagonism: From Synthetic Rescues to Multi-drug Combinations [PDF]

, 2010
Recent research shows that a faulty or sub-optimally operating metabolic network can often be rescued by the targeted removal of enzyme-coding genes--the exact opposite of what traditional gene therapy would suggest.
Adilson E. Motter, Baba, Blagosklonny, Bollenbach, Bourgeois, Burgard, Burgard, Cagatay, Chait, Cun, Dancey, Duarte, Edwards, Feist, Fischer, Fong, Fong, Fong, Fong, Fraenkel, Gerdes, Giaever, Goebl, Harrison, Hashimoto, Hegreness, Henry, Herring, Hilgetag, Hilgetag, Hillenmeyer, Hopkins, Huttenlocher, Huttenlocher, Isalan, Kauffman, Keiser, Kim, Kitano, Kupiec, Ma, Miller, Motter, Motter, Nishikawa, Olson, Palsson, Papp, Pharkya, Reguly, Segre, Segre, Shlomi, Timmermans, Wagner, Yeh, Yildirim, Yngvadottir, Zamboni   +58 more
core   +3 more sources

Variability of the Microbiota in Chronic Rhinosinusitis: A Scoping Review

OTO Open
Objective Chronic rhinosinusitis (CRS) is characterized by a persistent inflammation of the nasal and paranasal sinus mucosa that could be potentially linked to a dysregulation between the microbiota and the immune system.
Fabricio Ccami‐Bernal, Fernanda Barriga‐Chambi, Zhamanda N. Ortiz‐Benique, Evelyne Ferrary, Renato Torres   +4 more
doaj   +1 more source

Approaches for in silico finishing of microbial genome sequences

Genetics and Molecular Biology
The introduction of next-generation sequencing (NGS) had a significant effect on the availability of genomic information, leading to an increase in the number of sequenced genomes from a large spectrum of organisms.
Frederico Schmitt Kremer, Alan John Alexander McBride, Luciano da Silva Pinto   +2 more
doaj   +1 more source

Genetic drift at expanding frontiers promotes gene segregation [PDF]

, 2007
Competition between random genetic drift and natural selection plays a central role in evolution: Whereas non-beneficial mutations often prevail in small populations by chance, mutations that sweep through large populations typically confer a selective ...
Cavalli-Sforza, Currat, D. R. Nelson, Elena, Hegreness, Kardar, Koshland, McMurray, Murray, O. Hallatschek, P. Hersen, Pennisi, S. Ramanathan, Saito, Schroeder, Shapiro   +15 more
core   +2 more sources

Enabling precision medicine in neonatology, an integrated repository for preterm birth research [PDF]

, 2018
Preterm birth, or the delivery of an infant prior to 37 weeks of gestation, is a significant cause of infant morbidity and mortality. In the last decade, the advent and continued development of molecular profiling technologies has enabled researchers to ...
Chubiz, Jessica, England, Sarah K., Macones, George   +2 more
core   +5 more sources

Microbial degradation of dimethylsulphide and related C1-sulphur compounds: organisms and pathways controlling fluxes of sulphur in the biosphere [PDF]

, 2010
Dimethylsulphide (DMS) plays a major role in the global sulphur cycle. It has important implications for atmospheric chemistry, climate regulation, and sulphur transport from the marine to the atmospheric and terrestrial environments.
Boden, Rich, Myronova, Natalia, Schäfer, Hendrik   +2 more
core   +1 more source

Conserved Genome Organization and Core Transcriptome of the Lactobacillus acidophilus Complex

Frontiers in Microbiology, 2018
The Lactobacillus genus encompasses a genetically and functionally diverse group of species, and contains many strains widely formulated in the human food supply chain as probiotics and starter cultures. Within this genetically expansive group, there are
Alexandra B. Crawley, Alexandra B. Crawley, Rodolphe Barrangou, Rodolphe Barrangou   +3 more
doaj   +1 more source

Bacillus subtilis spores displaying RBD domain of SARS-CoV-2 spike protein

Computational and Structural Biotechnology Journal, 2023
Bacillus subtilis spores are considered to be efficient and useful vehicles for the surface display and delivery of heterologous proteins. In this study, we prepared recombinant spores with the receptor binding domain (RBD) of the SARS-CoV-2 spike ...
A. Vetráková, R. Kalianková Chovanová, R. Rechtoríková, D. Krajčíková, I. Barák   +4 more
doaj   +1 more source

Antibacterial Activity of Metabolites of Endophytic Bacillus subtilis Isolated From Selected Ethiopian Medicinal Plants

International Journal of Microbiology
Antimicrobial resistance remains a global concern, and there has been sustained exploration of natural products with therapeutic effects. Endophytes are among the potential microorganisms considered as the treasure chest for bioactive secondary ...
Tsedale Tasew, Dagim Jirata Birri, Fitsum Tigu, Dereje Beyene, Tegenu Gelana, Ketema Tolossa, Balako Gumi, Tigist Getachew, Iris Bertani, Vittorio Venturi, Dejene Guta, Asnake Desalegn   +11 more
doaj   +1 more source

Viral Diversity of House Mice in New York City

mBio, 2018
The microbiome of wild Mus musculus (house mouse), a globally distributed invasive pest that resides in close contact with humans in urban centers, is largely unexplored. Here, we report analysis of the fecal virome of house mice in residential buildings
Simon H. Williams, Xiaoyu Che, Joel A. Garcia, John D. Klena, Bohyun Lee, Dorothy Muller, Werner Ulrich, Robert M. Corrigan, Stuart Nichol, Komal Jain, W. Ian Lipkin   +10 more
doaj   +1 more source