Results 221 to 230 of about 535,232 (307)

A Microbiota‐ and IL‐15‐Dependent Innate‐Like B Cell Progenitor Expressing E4BP4

Advanced Science, EarlyView.
This work identifies CD3.NKp46.CD19.NK1.1. NK‐B cells enriched in PDK1‐deficient yet present in wild‐type bone marrow. IL‐15 (via CD122) and TLR9‐microbiota signaling maintain their E4BP4 expression. These cells demonstrate innate immunity, preferentially differentiate into B cells, and unveil a novel microbiota‐ and IL‐15‐dependent regulatory pathway ...
Junming He, Xinlei Hou, Xiaomei Feng, Yayun Dong, Mengqi Ren, Surong Deng, Xinru Yang, Donglin Chen, Lingna Zhao, Shasha Chen, Meixiang Yang, Zhongjun Dong   +11 more
wiley   +1 more source

Towards global healthy longevity: report from the 1st World Longevity Summit in Kyotango, Japan. [PDF]

NPJ Aging
Kitani T, Matoba S, Naito Y, Horvath S, Yoshimori T, Chan FKL, Matsuda T, Bandini S, Nakagami H, Morishita R, Nakayama Y, Yaku H.   +11 more
europepmc   +1 more source

Erucic Acid, Derived by Lactobacillus Crispatus, Induces Ferroptosis in Cervical Cancer Organoids Through the PPAR‐δ Signaling Pathway

Advanced Science, EarlyView.
Utilizing PDO, cell lines and cervical cancer xenograft (CDX) models, the study demonstrate both in vitro and in vivo that the metabolite of L. crispatus, erucic acid, can modulate the proliferation, migration and invasion of cervical cancer by activating the PPAR‐δ pathway.
Qianwei Zhen, Yuexuan Xu, Ying Xu, Xiao Liu, Yuting Zhang, Dan Ye, Sai Han, Shili Liu, Youzhong Zhang   +8 more
wiley   +1 more source

Experimental Immigration Mediates Ecological Selection and Drift in Monarch Microbiome Assembly. [PDF]

Ecol Lett
Catano CP, DuBose JG, Fuller-Hall L, Chavez J, de Roode JC.   +4 more
europepmc   +1 more source

Intestinal Neutral Ceramidase Deficiency Triggers Regulatory T Cell Response via Gd3 to Protect the Host from Intestinal Inflammation

Advanced Science, EarlyView.
Deletion of ASAH2 in intestinal epithelial cells induces the accumulation of ganglioside GD3 via regulating ST8SIA1. GD3 is identified as the glycolipid ligand for the inhibitory receptor Siglec‐E on macrophages. GD3/Siglec‐E ligation polarizes macrophages and promotes the proliferation of colonic ST2+ T regulatory cells via the induction of IL‐33. The
Zhishan Xu, Chao Lei, Mukesh K Sriwastva, Ting Wang, Amanguli Tuohongerbieke, Xiaotong Song, Collin Noud, Shannon Derkson, Yi Tan, Gerald Dryden, Craig J McClain, Zhongbin Deng   +11 more
wiley   +1 more source

Social Microbial Transmission in a Solitary Mammal. [PDF]

Ecol Lett
Petrullo L, Webber Q, Raulo A, Boutin S, Lane JE, McAdam AG, Dantzer B.   +6 more
europepmc   +1 more source

Trimetallic Nanozyme‐Embedded Smart Hydrogel Enables NIR‐Controlled Bacterial Killing and Oxidative Stress Alleviation

Advanced Science, EarlyView.
A microenvironment‐responsive hydrogel is developed incorporating polymyxin B‐modified AuMnCu nanozymes and dual drugs (tannic acid and tobramycin). At infection sites, it generates ROS, releases drugs responsively, and enhances mild photothermal action to disrupt bacterial redox balance.
Zehui Xiao, Jiangli Cao, Jifeng Liu, Zhiyong Song, Ting Du, Xinjun Du   +5 more
wiley   +1 more source

Key Challenges in Plant Microbiome Research in the Next Decade. [PDF]

Microorganisms
Fadiji AE, Adeniji A, Lanrewaju AA, Adedayo AA, Chukwuneme CF, Nwachukwu BC, Aderibigbe J, Omomowo IO.   +7 more
europepmc   +1 more source

An Efficient CO2‐Upcycling Platform Based on Engineered Halomonas TD with Enhanced Acetate‐Utilizing Capacity via Adaptive Laboratory Evolution

Advanced Science, EarlyView.
An electrochemical system is designed to convert CO2 into CO2‐derived electrolytes (CDE), mainly containing acetate and formate. The underlying mechanism of acetate metabolism in Halomonas TD80 is explored via ALE. Engineered TD80 produced high‐yield diversified products from CDE.
Chi Wang, Ting‐Ting Chen, Yu‐Jiao Yang, Yu‐Xi Li, Yi‐Xin Chang, Yan‐Chun Xiao, Wen‐Tai Guo, Ye Zheng, Rui‐Zhe Deng, Yu‐Xiang Tian, Wei Situ, Hong‐Wei Shen, Yu Chen, Ya‐Bin Wang, Jie Xing, Hui Wang, Lin Xia, Yi‐Na Lin, Jian‐Wen Ye   +18 more
wiley   +1 more source

Long-term homeostasis in microbial consortia via auxotrophic cross-feeding. [PDF]

Nat Commun
Grandel NE, Alexander AM, Peng X, Palamountain C, Alnahhas RN, Hirning AJ, Josić K, Bennett MR.   +7 more
europepmc   +1 more source