Results 21 to 30 of about 308,196 (199)
Analysis of Circuits for Dosage Control in Microbial Populations [PDF]
, 2020 Designing genetic circuits to control the behaviors of microbial populations is an ongoing challenge in synthetic biology. Here we analyze circuits which implement dosage control by controlling levels of a global signal in a microbial population in face ...
Clamons, Samuel E. +2 more
core
Survival of the simplest: the cost of complexity in microbial evolution [PDF]
, 2018 The evolution of microbial and viral organisms often generates clonal interference, a mode of competition between genetic clades within a population. In this paper, we show that interference strongly constrains the genetic and phenotypic complexity of evolving systems.
arxiv +1 more source
Reaching Agreement in Competitive Microbial Systems [PDF]
arXiv, 2021 We study distributed agreement in microbial distributed systems under stochastic population dynamics and competitive interactions. Motivated by recent applications in synthetic biology, we examine how the presence and absence of direct competition among microbial species influences their ability to reach majority consensus. In this problem, two species
arxiv
Shearing in flow environment promotes evolution of social behavior in microbial populations [PDF]
eLife 2018;7:e34862, 2017 How producers of public goods persist in microbial communities is a major question in evolutionary biology. Cooperation is evolutionarily unstable, since cheating strains can reproduce quicker and take over. Spatial structure has been shown to be a robust mechanism for the evolution of cooperation. Here we study how spatial assortment might emerge from
arxiv +1 more source
Prospects for the Study of Evolution in the Deep Biosphere [PDF]
, 2012 Since the days of Darwin, scientists have used the framework of the theory of evolution to explore the interconnectedness of life on Earth and adaptation of organisms to the ever-changing environment.
Biddle, Jennifer F. +7 more
core +4 more sources
Nematode migration and nutrient diffusion between vetch and barley material in soil [PDF]
, 2007 This paper deals with migration of nematodes along nutrient gradients in soil. Portions of barley straw and green vetch leaves were mixed with soil and buried at 6, 12, 18, and 50mm distance from each other in soil.
Alphei, Jörg +3 more
core +1 more source
Tiny microbes, enormous impacts: what matters in gut microbiome studies? [PDF]
, 2016 Many factors affect the microbiomes of humans, mice, and other mammals, but substantial challenges remain in determining which of these factors are of practical importance. Considering the relative effect sizes of both biological and technical covariates
Debelius, Justine +5 more
core +1 more source
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Microbial genomic taxonomy [PDF]
, 2013 A need for a genomic species definition is emerging from several independent studies worldwide. In this commentary paper, we discuss recent studies on the genomic taxonomy of diverse microbial groups and a unified species definition based on genomics ...
Chimetto, Luciane +5 more
core +3 more sources
Molecular Oncology, EarlyView.We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić +31 more
wiley +1 more source