Results 21 to 30 of about 148,444 (232)

Can regulatory T cells improve outcomes of sensitised patients after HLA-Ab incompatible renal transplantation: study protocol for the Phase IIa GAMECHANgER-1 trial

BMC Nephrology, 2023
Background Kidney transplantation is the gold-standard treatment for patients with kidney failure. However, one-third of patients awaiting a kidney transplant are highly sensitized to human leukocyte antigens (HLA), resulting in an increased waiting time
C Dudreuilh, P Jarvis, N Beadle, I Pilecka, O Shaw, L Gardner, C Scottà, N Mamode , DS Game, A Sanchez-Fueyo, G Lombardi, A Learoyd, A Douiri, A Dorling   +13 more
doaj   +1 more source

Temperature and the development rates of thrips: Evidence for a constraint on local adaptation?

European Journal of Entomology, 2002
Typically, the relationship between insect development and temperature is described by two characteristics: the minimum temperature needed for development to occur (Tmin) and the number of day degrees required (DDR) for the completion of development.
David A. STACEY, Mark D.E. FELLOWES
doaj   +1 more source

A more significant role for insertion sequences in large-scale rearrangements in bacterial genomes

mBio
Insertion sequences (ISs) are mobile pieces of DNA that are widespread in bacterial genomes. IS movements typically involve (i) excision of the IS element, (ii) cutting of target site DNA, and (iii) IS element insertion. This process generates a new copy
Wing Y. Ngan, Lavisha Parab, Frederic Bertels, Jenna Gallie   +3 more
doaj   +1 more source

Bottom-Up Approaches to Synthetic Cooperation in Microbial Communities

Life, 2019
Microbial cooperation pervades ecological scales, from single-species populations to host-associated microbiomes. Understanding the mechanisms promoting the stability of cooperation against potential threats by cheaters is a major question that only ...
Daniel Rodríguez Amor, Martina Dal Bello   +1 more
doaj   +1 more source

Prospects for the study of evolution in the deep biosphere

Frontiers in Microbiology, 2012
Since the days of Darwin, scientists have used the framework of the theory of evolution to explore the interconnectedness of life on Earth and adaptation of organisms to the ever-changing environment.
Jennifer F Biddle, Jason B Sylvan, William J. Brazelton, Benjamin J. Tully, Katrina eEdwards, Craig L. Moyer, John F Heidelberg, William C. Nelson   +7 more
doaj   +1 more source

Synthetic Biology Tools for Engineering Microbial Cells to Fight Superbugs

Frontiers in Bioengineering and Biotechnology, 2022
With the increase in clinical cases of bacterial infections with multiple antibiotic resistance, the world has entered a health crisis. Overuse, inappropriate prescribing, and lack of innovation of antibiotics have contributed to the surge of ...
Angel León-Buitimea, Angel León-Buitimea, Francisco de Jesús Balderas-Cisneros, Francisco de Jesús Balderas-Cisneros, César Rodolfo Garza-Cárdenas, César Rodolfo Garza-Cárdenas, Javier Alberto Garza-Cervantes, Javier Alberto Garza-Cervantes, José Rubén Morones-Ramírez, José Rubén Morones-Ramírez   +9 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Evolution of microbes and viruses: A paradigm shift in evolutionary biology?

Frontiers in Cellular and Infection Microbiology, 2012
When Charles Darwin formulated the central principles of evolutionary biology in the Origin of Species in 1859 and the architects of the Modern Synthesis integrated these principles with population genetics almost a century later, the principal if not ...
Eugene V. Koonin, Yuri I Wolf
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

CRISPR-induced distributed immunity in microbial populations. [PDF]

PLoS ONE, 2014
In bacteria and archaea, viruses are the primary infectious agents, acting as virulent, often deadly pathogens. A form of adaptive immune defense known as CRISPR-Cas enables microbial cells to acquire immunity to viral pathogens by recognizing specific ...
Lauren M Childs, Whitney E England, Mark J Young, Joshua S Weitz, Rachel J Whitaker   +4 more
doaj   +1 more source