Results 231 to 240 of about 948,954 (362)

A Modular and Customizable CRISPR/Cas Toolkit for Epigenome Editing of Cis‐regulatory Modules

open access: yesAdvanced Science, EarlyView.
Epigenome editing surpasses genome editing in gene regulation. Modular epigenome editing frameworks are developed to interrogate cis‐regulome, enabling tunable reprogramming of cis‐elements, uncovering their epigenetic responsiveness and cross‐species portability.
Lingrui Zhang   +6 more
wiley   +1 more source

Movement Mechanisms Harness Lévy Flight for Energy‐Efficient Wastewater Treatment in Microalgae–Bacteria Systems

open access: yesAdvanced Science, EarlyView.
Here, our novel model that integrates metabolism with motility dynamics reveals that microalgae shift bacterial movement toward Lévy flight patterns, enhancing encounter rates and self‐aggregation. This microecological manipulation reduces energy costs, strengthens functions such as pollutant removal and system stability.
Luyu Zhang   +7 more
wiley   +1 more source

Stool shed cell transcriptomics mirrors tumor biology and enables colorectal cancer diagnosis. [PDF]

open access: yesSci Rep
Bahar Halpern K   +9 more
europepmc   +1 more source

Restoring Histone Acetylation Accelerates Diabetic Wound Repair by Improving the Spatiotemporal Dynamics of Macrophages

open access: yesAdvanced Science, EarlyView.
Butyrate—via epigenetic modulation of the histone core—rebalance dysregulated macrophage function and promotes wound healing under persisting hostile conditions of diabetic mice. Additionally, butyrate harmonizes macrophage interactions with keratinocytes and fibroblasts as well as breaks the vicious cycle of inflammation in chronic wounds by restoring
Karmveer Singh   +11 more
wiley   +1 more source

The Gut Resistome Atlas in Preterm Infants Enables Prediction of Necrotizing Enterocolitis Onset

open access: yesAdvanced Science, EarlyView.
The gut resistome of preterm infants and its clinical relevance remain poorly understood. This study performs in‐depth integrative analyses of 5,684 gut metagenomes from preterm infants, uncovering distinct features that diverge from term infants. Notably, the gut resistome of preterm infants converges 9 days before necrotizing enterocolitis onset ...
Shuqin Zeng   +22 more
wiley   +1 more source

Microbial Community Succession Sustains Fish Diversity in the Upper Yangtze River Reserve

open access: yesAdvanced Science, EarlyView.
Critical for river ecosystem sustainability, fish diversity relates to multitrophic microbes. This upper Yangtze FNNR study used eDNA to examine microbial succession‐fish links, finding key drivers, distinct assembly processes, and that microbial cross‐trophic interactions benefit fish, offering conservation insights.
Jiaxin Huang   +12 more
wiley   +1 more source

Symptoms as an Indicator of Microbial Keratitis Severity and Its Association With Visual Acuity. [PDF]

open access: yesEye Contact Lens
Ballouz D   +14 more
europepmc   +1 more source

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