Results 231 to 240 of about 935,221 (361)

From Culture-Negative to DNA-Positive: The Molecular Revolution in Infective Endocarditis Diagnosis. [PDF]

Pathogens
Kim M, Fida M, Abu Saleh OM, Ranganath N.   +3 more
europepmc   +1 more source

Bacterial Foreignization Nanosystem Elicits Multi‐Phenotypic T Cells for Antitumor Immunity

Advanced Science, EarlyView.
In this study, a comprehensive strategy for tumor immunogenicity reshaping is implemented, in which all adjuvanticity, antigenicity, and reactogenicity of tumor cells are highly improved by an engineered bacterial nanosystem through a selective membrane fusion process. The resulting foreignized tumor cells evoke potent innate immune responses, inducing
Wan‐Ru Zhuang, Wen‐Chi Xue, Chao Liang, Pan Liu, Yao Lei, Jiaqi He, Ran Cheng, Weidong Nie, Jianxiong Wang, Jie Tang, Hai‐Yan Xie   +10 more
wiley   +1 more source

Neutrophil‐Mimicking Nanomedicine Eliminates Tumor Intracellular Bacteria and Enhances Chemotherapy on Liver Metastasis of Colorectal Cancer

Advanced Science, EarlyView.
Fusobacterium nucleatum (Fn) enrichment has been identified in colorectal cancer and its liver metastases. This study develops neutrophil‐mimicking nanoparticles with multiple targeting capabilities encapsulating metronidazole and oxaliplatin for antibacterial and anticancer purposes. This approach reverses the epithelial mesenchymal transition process
Yanan Niu, Xu Zhao, Yong Li, Xiaoya Ma, Weifeng Yang, Jie Ma, Wanglin Li, Wei Yuan   +7 more
wiley   +1 more source

Laboratory validation of targeted next-generation sequencing assay for pathogen detection in lower respiratory infection. [PDF]

Microbiol Spectr
Yang J, Wang Y, Yang L, Wu J.
europepmc   +1 more source

Akkermansia Muciniphila Alleviates Severe Acute Pancreatitis via Amuc1409‐Ube2k‐Foxp3 Axis in Regulatory T Cells

Advanced Science, EarlyView.
Akkermansia depletion correlates with acute pancreatitis (AP) severity. A. muciniphila and its protein Amuc_1409 mitigate pancreatic/systemic inflammation by expanding Tregs and IL‐10. Mechanistically, Amuc_1409 binds Ube2k, inhibiting Foxp3 ubiquitination to stabilize Treg differentiation and IL‐10 production, countering SAP‐induced SIRS/CARS ...
Jinyan Xie, Lijun Du, Yunkun Lu, Xiuliu Guo, Xinyuan Zhou, Yifan Tong, Bo Shen, Xin Yu, Feng Guo, Hong Yu   +9 more
wiley   +1 more source

Clinical Value of Metagenomic Next-Generation Sequencing in Early Diagnosis of Peritoneal Dialysis-Associated Peritonitis: A Randomised Controlled Observational Trial. [PDF]

Nephrology (Carlton)
Li A, Chen Z, Deng Q, Zheng C, Hu H, Ye Z.   +5 more
europepmc   +1 more source

Current Approaches and Challenges in Advanced Oxidation Processes for Nanoplastic Degradation

Advanced Science, EarlyView.
This review explores recent progress in advanced oxidation processes (AOPs) for the degradation of nanoplastics (NPs) in water. It presents a comparative assessment of key AOP technologies and identifies current limitations in analytical methods and treatment efficiency.
Arezou Fazli, Athanassia Athanassiou, Despina Fragouli   +2 more
wiley   +1 more source

Identification of clinically relevant profiles in colorectal cancer through integrated analysis of bacterial DNA and metabolome in serum. [PDF]

Front Immunol
Vicente-Valor J, Tesolato S, Gómez-Garre D, Paz-Cabezas M, Ortega-Hernández A, Fernández-Hernández C, de la Serna S, Domínguez-Serrano I, Dziakova J, Rivera D, Rupérez FJ, García A, Torres A, Iniesta P.   +13 more
europepmc   +1 more source

Multi‐Omics and ‐Organ Insights into Energy Metabolic Adaptations in Early Sepsis Onset

Advanced Science, EarlyView.
This study shows that patients at risk of sepsis have a distinct metabolite and lipid signature, including serine and aminoadipic acid, in their serum before clinical diagnosis. A mouse model of sepsis with a compatible serum signature reveals underlying metabolic changes, including mitochondrial adaptation, altered serine‐dependent purine metabolism ...
Lin‐Lin Xu, Zhengyuan Zhou, Sascha Schäuble, Wolfgang Vivas, Karen Dlubatz, Michael Bauer, Sebastian Weis, Mervyn Singer, Roman Lukaszewski, Gianni Panagiotou   +9 more
wiley   +1 more source

Two Subunits of the Rpd3 Histone Deacetylase Complex of Cochliobolus heterostrophus Are Essential for Nitrosative Stress Response and Virulence, and Interact With Stress-Response Regulators ChHog1 and ChCrz1. [PDF]

Mol Plant Pathol
Fan J, Hu J, Li D, Tian Y, Jia M, Liang T, Pan H, Zhang X.   +7 more
europepmc   +1 more source