Results 241 to 250 of about 978,525 (344)

Amodiaquine Enhances Anti‐Melanoma Efficacy of Attenuated Salmonella via Targeting Glutathione Reductase in Neutrophils

Advanced Science, EarlyView.
This study shows that Salmonella VNP20009 recruits pro‐tumor neutrophils that reduce its anticancer efficacy. Combining VNP with amodiaquine selectively eliminates these neutrophils by targeting glutathione reductase. A GR‐shRNA‐loaded VNP strain was further developed, demonstrating an innovative strategy integrating drug repurposing with synthetic ...
Wanfa Dong, Chunyuan Zhao, Chengxi Li, Lin Weng, Zehan Ji, Peiqi Li, Jiqiang Lu, Danni Liu, Anni Yu, Tianyi Jiang, Shaokai Huang, Heng Liu, Xiao Chen, Zichun Hua   +13 more
wiley   +1 more source

Hot Electron‐Assisted Noble‐Metal‐Free Synergistic Photothermal Catalyst for Solar‐Driven Wastewater Remediation and Microbial Disinfection

Advanced Science, EarlyView.
A multifunctional Bi2Te3@CdS hybrid system is presented for solar‐driven wastewater remediation and indoor disinfection. The catalyst coated on PU foam efficiently harvests visible‐NIR light to generate heat and reactive oxygen species, enabling the rapid mineralization of organic pollutants.
Manish Kumar Sharma, Bishal Kumar Nahak, Parag Parashar, Uday Kumar Singh, Arshad Khan, Jaba Roy Chowdhury, Parthasarathi Pal, Dongwhi Choi, Hae Gyun Lim, Yu‐Lun Chueh, Zong‐Hong Lin   +10 more
wiley   +1 more source

Diagnostic value of plasma cell-free DNA metagenomic next-generation sequencing in patients with suspected infections and exploration of clinical scenarios-a retrospective study from a single center. [PDF]

Ann Med
Sun S, Ning Z, Xu H, Peng S, Gao C, Hu X.   +5 more
europepmc   +1 more source

Parallel Genome‐Wide CRISPR Screens Reveal SORL1 and ZFYVE19 as Sequential Host Determinants of Salmonella Infection

Advanced Science, EarlyView.
To distinguish how Salmonella invades cells vs how it survives long‐term, a parallel CRISPR screening platform is developed. This approach reveals the host proteins that the bacterium exploits at different stages of infection. The study identifies SORL1 as a novel host factor for invasion and demonstrates that blocking it with an antibody effectively ...
Sehee Yun, Seoyeon Kim, Seonggyu Kim, Minsoo Noh, Dae‐Kyum Kim, Eun‐Jin Lee, Hunsang Lee   +6 more
wiley   +1 more source

Oral short-chain fatty acid-producing bacteria may be associated with biological age and cognition among the oldest old. [PDF]

Commun Med (Lond)
Wehnes T, Wang W, Tay JH, Guan L, Feng L, Ho CMR, Ng TP, Kennedy BK, Venkitaraman A, Koh WP, Chong YS, Maier AB.   +11 more
europepmc   +1 more source

Systematic Benchmarking of a Noise‐Tolerant Conductive Hydrogel Electrode for Epidermal Bioelectronics

Advanced Science, EarlyView.
General schematic of the approach. Abstract Conventional Silver/Silver Chloride (Ag/AgCl) electrodes remain the clinical standard for electrophysiological monitoring but are hindered by poor skin conformity, mechanical rigidity, and signal degradation, particularly under motion or sweat.
Nazmi Alsaafeen, Ioannis Ziogas, Shirina Alsaedi, Mouza Alshehhi, Shahd Almheiri, Adil Rehman, Khulood Al Shehhi, Hani Saleh, Ahsan Khandoker, Charalampos Pitsalidis, Antoun Khawaja, Anna‐Maria Pappa   +11 more
wiley   +1 more source

Gut microbiota, lipid metabolism, and PCOS: A Mendelian randomization and mediation analysis. [PDF]

Medicine (Baltimore)
Li W, Gan J, Jiao J, Li J, Xu L, Li D, Geng Y, Shen M, Liang J, Lin H, Zhong L.   +10 more
europepmc   +1 more source

Halorotetin B, A Novel Terpenoid Compound Derived from Marine Ascidian, Suppresses Tumor Growth by Targeting the Cell Cycle Regulator UBE2C

Advanced Science, EarlyView.
Halorotetin B, a novel small‐molecule terpenoid identified from an edible marine ascidian, exhibits strong anti‐tumor activity both in vitro and in vivo through direct targeting UBE2C to induce tumor cell cycle arrest and then lead tumor cell senescence. As a newly discovered UBE2C inhibitor, Halorotetin B can serve as a novel potential cell senescence
Shanhao Han, Jianhui Li, Yuting Zhu, Penghui Liu, Yaoyao Zheng, Muchun He, Bo Dong   +6 more
wiley   +1 more source

Diagnostic oral microbiota signatures for gastric cancer and associations with carcinogenic signaling pathways. [PDF]

J Oral Microbiol
Kim YH, Choi IJ, Ryu KW, Kim YI, Praveen Z, Kim MK.   +5 more
europepmc   +1 more source