Results 41 to 50 of about 2,383,613 (259)

Preprinting Microbiology

open access: yesmBio, 2017
The field of microbiology has experienced significant growth due to transformative advances in technology and the influx of scientists driven by a curiosity to understand how microbes sustain myriad biochemical processes that maintain Earth.
Patrick D. Schloss
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Laboratory Focus on Improving the Culture of Biosafety: Statewide Risk Assessment of Clinical Laboratories That Process Specimens for Microbiologic Analysis [PDF]

open access: yes, 2018
The Wisconsin State Laboratory of Hygiene challenged Wisconsin laboratories to examine their biosafety practices and improve their culture of biosafety.
Batemman, Allen C.   +13 more
core   +1 more source

Establishing molecular microbiology facilities in developing countries

open access: yesJournal of Infection and Public Health, 2015
Summary: Microbiology laboratories play an important role in epidemiology and infection control programs. Within microbiology laboratories, molecular microbiology techniques have revolutionized the identification and surveillance of infectious diseases ...
Salman S. Ahmed   +3 more
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Robert Koch, Creation, and the Specificity of Germs [PDF]

open access: yes, 2010
Microbiology is dominated by evolution today. Just look at any text, journal article, or the topics presented at professional scientific meetings. Darwin is dominant. Microbiology is dominated by evolution today.
Gillen, Alan L.   +2 more
core   +1 more source

Phyllosphere microbiology with special reference to diversity and plant genotype [PDF]

open access: yes, 2008
The phyllosphere represents the habitat provided by the aboveground parts of plants, and on a global scale supports a large and complex microbial community.
Adams   +111 more
core   +1 more source

Bugs and Drugs: An Integrated Case-Based Microbiology-Pharmacology Session on Respiratory Infections

open access: yesMedEdPORTAL, 2013
This interactive small-group session integrates microbiology of the respiratory tract with pharmacology (antimicrobials). It is intended as a review following lectures or interactive sessions in basic microbiology, respiratory microbiology, and ...
Melphine Harriott, Senthil Rajasekaran
doaj   +1 more source

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