Results 161 to 170 of about 376,828 (315)

Targeted Delivery of Indole‐3‐Pyruvic Acid Suppresses Macrophage Ferroptosis to Enhance CD8+ T Cell‐Mediated Immunotherapy Response in Bladder Cancer

Advanced Science, EarlyView.
A microbiota‐derived metabolite, indole‐3‐pyruvic acid, suppresses macrophage ferroptosis through the AHR–NF‐κB–SLC7A11 axis. This preserves CD8+ T cell function in bladder cancer. Macrophage‐targeted nanoparticles enhance indole‐3‐pyruvic acid delivery and overcome resistance to PD‐1 blockade.
Jianwen Lao, Xinhao Yuan, Shuai Liang, Kai Deng, Daqin Wu, Longhao Xu, Kun Zheng, Yi Lin, Peicong Cai, Haoran Zheng, Junyu Chen, Mingli Luo, Yan Chen, Xiong Chen, Chunhui Wang, Wenlong Zhong   +15 more
wiley   +1 more source

Microbiome multi-omics can accelerate human excrement composting research

Microbiome
In this editorial, we discuss the need for a new, long-term strategy for managing human excrement (feces and urine) to facilitate health equity and promote environmental sustainability. Human excrement composting (HEC), a human-directed process driven by
Jeff Meilander, Mary Jewell, J. Gregory Caporaso   +2 more
doaj   +1 more source

High Tree Species Diversity Promotes Thermal Enhancement Response of Microbial Carbon Use Efficiency

Advanced Science, EarlyView.
ABSTRACT Predicting soil carbon dynamics under warming is constrained by limited understanding of microbial thermal adaptation, particularly whether microbial carbon use efficiency (CUE) can adapt to warming and how plant diversity modulates this response. Using soils from a natural tree species diversity gradient in a subtropical forest, we combined a
Pengpeng Duan, Changqing Ye, Xinyi Yang, Chaoqun Wang, Wolfgang Wanek, Jian‐sheng Ye, Hongzhao Yuan, Hu Du, Kongcao Xiao, Xunyang He, Kelin Wang, Dejun Li   +11 more
wiley   +1 more source

RHINO: An Integrative Multi‐Omics Framework Linking Circadian Physiology to Precision Medicine

Advanced Science, EarlyView.
RHINO (RHythmic Interacting Network for multi‐Omics) is an integrative framework that maps circadian regulation across diverse genetic and disease contexts and prioritizes druggable circadian targets. Released as an AI‐powered interactive web portal, RHINO unifies genetic, regulatory, disease, and drug–target information, enabling context‐specific ...
Ying Chen, Chengxuan Chen, Dishu Zhou, Panpan Liu, Roberto E. López‐Valiente, Yuan Liu, Cam Mong La, Isabella Beraldo Xavier, Sean M. Hartig, Pradip Saha, Zheng Sun, Leng Han, Dongyin Guan   +12 more
wiley   +1 more source

Transcriptomic Insights into Adaptive Strategies of Klebsiella pneumoniae Co-Producing KPC-2 and NDM-5 Carbapenemases Under Meropenem Stress

Infection and Drug Resistance
Liting Dai,1,* Huimin Zhang,1,* Yingyi Cao,1,* Jiacheng Ding,1 Jiaxin Tang,2 Zhirou Xiao,2 Zhemei Chen,2 Jiahui Ling,1 Mengxue Zou,1 Xiwu Cao,1 Lijuan Lin,1 Ziheng Xu,1 Wanting Liu,1 Dingqiang Chen,1 Peibo Yuan1 1Microbiome ...
Dai L, Zhang H, Cao Y, Ding J, Tang J, Xiao Z, Chen Z, Ling J, Zou M, Cao X, Lin L, Xu Z, Liu W, Chen D, Yuan P   +14 more
doaj  

Developing a Coccidioides posadasii and SARS-CoV-2 Co-infection Model in the K18-hACE2 Transgenic Mouse

Communications Medicine
Background Early reports showed that patients with COVID-19 had recrudescence of previously resolved coccidioidomycosis (Valley fever, VF), and there were indications that coinfection had more severe outcomes.
Daniel R. Kollath, Francisca J. Grill, Ashley N. Itogawa, Ana Fabio-Braga, Matthew M. Morales, Kelly M. Shepardson, Mitchell L. Bryant, Jinhee Yi, Marieke L. Ramsey, Emily T. Luberto, Kimberly R. Celona, Paul S. Keim, Erik W. Settles, Douglas Lake, Bridget M. Barker   +14 more
doaj   +1 more source

Metagenomic Association Uncovers Host Genotype‐Structured Rhizobacterial Networks and Novel Taxa That Enhance Soybean Salt Tolerance

Advanced Science, EarlyView.
An STI‐guided metagenomic association framework links soybean salt‐tolerance phenotypes with rhizosphere microbiome composition and network organization in natural saline soils. The approach identifies candidate beneficial taxa, including Thalassospira xiamenensis, and provides an efficient strategy for mining stress‐protective microbes from native ...
Yu Luo, Feng‐Li Kang, Qi‐Min Li, Wei‐Cai Yang   +3 more
wiley   +1 more source

Bioengineered Exosome‐Loaded Immunomodulatory Bioadhesive Spray Reverses Liver Fibrosis and Metabolic Dysfunction That Triggers Beneficial Gut‐Liver Crosstalk in Chronic Fatty Liver Disease

Advanced Science, EarlyView.
Umbilical cord stem cell‐derived exosomes encapsulated in an immunomodulatory bioadhesive hydrogel spray enable localized therapy, sustained vesicle delivery, macrophage polarization, suppress systemic inflammation, and mitigate glucose and insulin homeostasis impairments in MAFLD.
Triya Saha, Ayushi Mairal, Shreya Mehrotra, Shiv K. Sarin, Ashok Kumar   +4 more
wiley   +1 more source

Enhancing the Monogastric Gut Microbiome Through Innovative Nutritional Strategies [PDF]

The host and microbiome can be viewed as one integrated system, which highlights the need to optimize nutrition for both the host and its gut microbiome. This thesis explored the use of nutritional strategies as selective forces to support gut microbiome
Lu, Jing
core  

Combining mucosal microbiome and host multi-omics data shows prognostic potential in paediatric ulcerative colitis

Nature Communications
Current first-line treatments of paediatric ulcerative colitis (UC) maintain a 6-month remission in only half of the patients. Relapse prediction at diagnosis could enable earlier introduction of immunosuppressants.
Maria Kulecka, Jill O’Sullivan, Rachel Fitzgerald, Ana Velikonja, Chloe E. Huseyin, Emilio J. Laserna-Mendieta, Patricia Ruiz-Limón, Julia Eckenberger, Miriam Vidal-Marín, Bastian-Alexander Truppel, Raminder Singh, Sandhia Naik, Nicholas M. Croft, Andriy Temko, Aldert Zomer, John MacSharry, Silvia Melgar, Protima Deb, Ian R. Sanderson, Marcus J. Claesson   +19 more
doaj   +1 more source