Results 191 to 200 of about 675,129 (379)

Diversity and Ecological Potentials of Marine Viruses Inhabiting Continental Shelf Seas

open access: yesAdvanced Science, EarlyView.
To the best of the knowledge, this study provides the largest viral genome dataset from a continental shelf sea. It reveals that over half of vOTUs are novel, highlighting the remarkable viral novelty in the eastern continental shelf seas of China (ECSSC).
Xiaoyue Guo   +9 more
wiley   +1 more source

Longitudinal Analysis of the Microbiome and Metabolome in the 5xfAD Mouse Model of Alzheimer’s Disease

open access: gold, 2022
Sage J. B. Dunham   +6 more
openalex   +1 more source

Multi‐Omics Reveal the Dysregulated Gut‐Joint Axis in Knee Synovitis: Data from Two Osteoarthritis Studies in China

open access: yesAdvanced Science, EarlyView.
The “gut‐joint axis” in knee synovitis is uncovered. Integrated multi‐omics studies are conducted in two independent osteoarthritis cohorts. Synovitis is characterized an increased F/B ratio, as well as alterations of 3‐HIA, geranic acid, and TWEAK. Upregulated TWEAK receptor is found in high‐grade synovitis, and inversely correlated with lower TWEAK ...
Xiaoshuai Wang   +22 more
wiley   +1 more source

Chronic PET‐Microplastic Exposure: Disruption of Gut–Liver Homeostasis and Risk of Hepatic Steatosis

open access: yesAdvanced Science, EarlyView.
Chronic exposure to environmentally relevant PET microplastics disrupts gut–liver homeostasis, leading to hepatic steatosis, early fibrosis, and altered gut microbiota. These effects signal metabolic imbalance and gut–liver axis impairment, emphasizing chronic microplastic ingestion as an emerging environmental health risk linked to non‐communicable ...
Surye Park   +5 more
wiley   +1 more source

Developing a Coccidioides posadasii and SARS-CoV-2 Co-infection Model in the K18-hACE2 Transgenic Mouse

open access: yesCommunications Medicine
Background Early reports showed that patients with COVID-19 had recrudescence of previously resolved coccidioidomycosis (Valley fever, VF), and there were indications that coinfection had more severe outcomes.
Daniel R. Kollath   +14 more
doaj   +1 more source

Mitochondria: An Integrative Hub Coordinating Circadian Rhythms, Metabolism, the Microbiome, and Immunity [PDF]

open access: gold, 2020
Bruno A. Aguilar‐López   +4 more
openalex   +1 more source

Soil salinization accelerates microbiome stabilization in iterative selections for plant performance [PDF]

open access: hybrid, 2021
William L. King   +5 more
openalex   +1 more source

Self‐Assembled Dictamni Cortex Nanoparticles Ameliorate Psoriasis by Epigenetic Modulation of HSP90AB1 and Suppression of the Inflammatory Response

open access: yesAdvanced Science, EarlyView.
This study develops self‐assembled Dictamni Cortex (BXP)‐Fe(III) infinite coordination polymer nanoparticles (NB) to improve BXP's solubility and bioavailability for psoriasis. NB transdermally treats psoriasis by targeting the epigenetic regulator CTCF (CCCTC‐binding factor), suppressing HSP90AB1 (heat shock protein 90 alpha family class B member 1 ...
Zhengyi Zhang   +15 more
wiley   +1 more source

A Microbiota‐ and IL‐15‐Dependent Innate‐Like B Cell Progenitor Expressing E4BP4

open access: yesAdvanced Science, EarlyView.
This work identifies CD3.NKp46.CD19.NK1.1. NK‐B cells enriched in PDK1‐deficient yet present in wild‐type bone marrow. IL‐15 (via CD122) and TLR9‐microbiota signaling maintain their E4BP4 expression. These cells demonstrate innate immunity, preferentially differentiate into B cells, and unveil a novel microbiota‐ and IL‐15‐dependent regulatory pathway ...
Junming He   +11 more
wiley   +1 more source

Home - About - Disclaimer - Privacy