Results 251 to 260 of about 4,737,444 (281)
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Engineering the gut microbiome
Nature Reviews Bioengineering, 2023Tao Zuo, Fen Zhang, Guoxin Li
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Emerging Frontiers in Microbiome Engineering
Trends in Immunology, 2019The gut microbiome has a significant impact on health and disease and can actively contribute to obesity, diabetes, inflammatory bowel disease, cardiovascular disease, and neurological disorders. We do not yet have the necessary tools to fine-tune the microbial communities that constitute the microbiome, though such tools could unlock extensive ...
Cesar de la Fuente-Núñez +2 more
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Engineering mucus to study and influence the microbiome
Nature Reviews Materials, 2019Mucus is a 3D hydrogel that houses the majority of the human microbiome. The mucous environment plays an important role in the differentiation and behaviour of microbial phenotypes and enables the creation of spatial distributions. Dysregulation of mucus is further associated with various diseases.
Caroline Werlang +2 more
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Microbiome engineering for bioremediation of emerging pollutants
Bioprocess and Biosystems Engineering, 2022Axenic microbial applications in the open environment are unrealistic and may not be always practically viable. Therefore, it is important to use mixed microbial cultures and their interactions with the microbiome in the targeted ecosystem to perform robust functions towards their sustainability in harsh environmental conditions.
L. Paikhomba Singha, Pratyoosh Shukla
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Leveraging diet to engineer the gut microbiome
Nature Reviews Gastroenterology & Hepatology, 2021Autoimmune diseases, including inflammatory bowel disease, multiple sclerosis and rheumatoid arthritis, have distinct clinical presentations but share underlying patterns of gut microbiome perturbation and intestinal barrier dysfunction. Their potentially common microbial drivers advocate for treatment strategies aimed at restoring appropriate ...
Mathis Wolter +6 more
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Harnessing intercellular signals to engineer the soil microbiome
Natural Product Reports, 2022This review covers intercellular signalling in the soil microbiome and its importance in regulating key beneficial functions. We consider the possibilities for how we can engineer soil microbiome signalling to unlock tangible benefits to crops.
Jack A. Connolly +5 more
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Microbiome and metabolism: Advancements in microbiome engineering
Current Opinion in Endocrine and Metabolic Research, 2022Chrystal F. Mavros, Carlotta Ronda
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Applying ecological principles to microbiome engineering
Nature MicrobiologyMicrobiome engineering seeks to reshape microbial communities to improve ecosystem function. However, many efforts fail due to inadequate design principles, often resulting in a loss of key microorganisms and disruption of links between the engineered community and its intended function.
Lucas P. Henry, Joy Bergelson
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Machine Learning in Microbiome Research and Engineering
ACS Synthetic BiologyMicrobiomes, complex communities of microorganisms and their genetic material, hold immense potential for addressing global challenges in diverse sectors, including healthcare, agriculture, and bioproduction. Engineering these intricate ecosystems, however, necessitates a comprehensive understanding of the complex web of microbial interactions.
Ryan De Sotto +3 more
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