Results 141 to 150 of about 29,847 (288)

Smart mesoporous silica nanoparticles for precision cancer therapy: Tumor targeting and stimuli‐responsive controlled release

Smart Molecules, EarlyView.
Smart mesoporous silica nanoparticles integrate tunable pore structures, molecular gates, targeting ligands, and stimuli‐responsive components to achieve controlled drug release for precision cancer therapy. This review highlights design principles, therapeutic applications, and future directions in immunotherapy, biodegradability, biosafety, and ...
Majdi Al‐Amili, Lei Lei, Zhu Jin
wiley   +1 more source

Programmable Porosity in Polymers via Microfluidic Templating and 3D Printing

Small Methods, EarlyView.
Fluid templating is a powerful way to produce porous polymers. Microfluidic technologies enable fine control over the dimension and packing of bubbles and droplets. Combined with additive manufacturing, microfluidic templating enables the creation of polymeric functionally graded porous materials in which both porosity and three‐dimensional geometry ...
Federico Serpe, Roberta Angelini, Andrea Barbetta, Vanessa Rosciardi   +3 more
wiley   +1 more source

Nonthermal plasma approaches for combating implant‐associated infections: A compendious review

VIEW, EarlyView.
Implant‐associated infections pose serious clinical challenges. Non‐thermal plasma (NTP) modifications overcome this bottleneck in distinct ways relative to traditional sterilization methods. Gas‐phase plasmas generate highly energetic species, UV radiation and reactive oxygen/nitrogen species (RONS), which alter the implant surface properties.
A. M. Trimukhe, Satish Rojekar, Amol Gholap, K. Navaneetha Pandiyaraj, Mukesh Patekar, Claudia Riccardi, R. R. Deshmukh, Tomáš Kovářík, Kalim Deshmukh   +8 more
wiley   +1 more source

Microbubbles coupled to methotrexate-loaded liposomes for ultrasound-mediated delivery of methotrexate across the blood–brain barrier

International Journal of Nanomedicine, 2014
Xiang Wang,1 Ping Liu,1 Weixiao Yang,1 Lu Li,1 Peijing Li,2 Zheng Liu,1 Zhongxiong Zhuo,1 Yunhua Gao1 1Department of Ultrasound, Xinqiao Hospital of the Third Military Medical University, Chongqing, 2Department of Ultrasound, General Hospital of ...
Wang X, Liu P, Yang W, Li L, Li P, Liu Z, Zhuo Z, Gao Y   +7 more
doaj  

Nanobodies as next‐generation targeting platforms: From discovery technologies to translational biomedicine

VIEW, EarlyView.
Nanobodies, derived from the variable domains of camelid heavy‐chain‐only antibodies, have emerged as transformative biomedical tools due to their nanoscale size, exceptional stability, and unique capacity to recognize cryptic epitopes. This review provides a comprehensive overview of the field, outlining the structural and biochemical features of ...
Zhenrui Ye, Xianyang Li, Meixiao Zhan
wiley   +1 more source

Diffusion of Characteristic Gases in Oil‐Immersed Transformer by Computational Fluid Dynamics Simulation and Experimental Verification

High Voltage, EarlyView.
ABSTRACT The complex diffusion of characteristic gases within oil‐immersed transformers significantly influences the timeliness between the fault occurrence and gas detection. So far, the gas transport processes and spatio‐temporal distributions remain inadequately understood.
Chunpeng Li, Yuan Li, Jianyi Wang, Zhengqin Zhou, Zhihao Liu, Zhiqiu Chen, Dongyang Zheng, Guanjun Zhang   +7 more
wiley   +1 more source

Preparation of vascular endothelial growth factor receptor 2-targeted ultrasonic contrast agent and its ability of targeting tumor cells in vitro

肿瘤影像学, 2016
Objective: To evaluate the targeting ability of vascular endothelial growth factor receptor 2 (VEGFR2)-targeted microbubbles to tumor cells and its preparation process.
YUAN Haixia, TANG Yang, WANG Hantao, KONG Wentao, WANG Wenping   +4 more
doaj  

Pleiotropic Roles of FBXO11 in Tumorigenesis: Implications for Targeted Therapy

Cancer Science, EarlyView.
This complex comprises of scaffold CUL1, SKP1, RBX1 and FBXO11 receptor. The substrate is phosphorylated by specific kinase enzyme and recognized by the substrate recognition domain. FBXO11 targets numerous substrates for ubiquitination and degradation, FBXO11 substrates mainly include Snail, ZEB1, p53, BCL6, CDT2, CIITA, Cdc25a, hnRNPA2B1, SAMD1 and ...
Yuqi Zhang, Changyi Fan, Shiheng Chen, Tianyue Lu, Yuanyuan Li, Feng Du, Shanshan Wang   +6 more
wiley   +1 more source

Effect of ultrasonic burst microbubbles on microwave coagulation hemostasis in a pig model of hepatic hemorrhage

Scientific Reports
To investigate the hemostatic efficacy of ultrasound in flash mode and/or microbubbles-assisted microwave coagulation for active liver hemorrhage. Thirty miniature pigs were randomly divided into five groups.
Bibo Peng, Shengnan Li, Nong Gao, Zhaojie Guan, Huina Song, Xiangnan Gao, Qu Liu, Lusi He, Jing Guo, Lina An   +9 more
doaj   +1 more source

Ion Channel Dysfunction and Therapeutic Targeting in Salivary Gland Disorders

Oral Diseases, EarlyView.
ABSTRACT Objective Salivary gland hypofunction and xerostomia represent major clinical complications of radiation therapy, autoimmune disorders such as Sjögren's disease, and inherited epithelial ion transport defects. This review integrates current knowledge on ion channel dysfunction as a central mechanistic driver of salivary gland pathology and ...
Tarek Mohamed Abd El‐Aziz, Shankara N. Varadarajan, Viktor Drel, Prakash Arullampalam, Mahmoud I. Shoulkamy, Ahmed Al‐Sabi, Brij B. Singh   +6 more
wiley   +1 more source