Results 141 to 150 of about 29,704 (268)

Nanobodies as next‐generation targeting platforms: From discovery technologies to translational biomedicine

open access: yesVIEW, EarlyView.
Nanobodies, derived from the variable domains of camelid heavy‐chain‐only antibodies, have emerged as transformative biomedical tools due to their nanoscale size, exceptional stability, and unique capacity to recognize cryptic epitopes. This review provides a comprehensive overview of the field, outlining the structural and biochemical features of ...
Zhenrui Ye, Xianyang Li, Meixiao Zhan
wiley   +1 more source

Diffusion of Characteristic Gases in Oil‐Immersed Transformer by Computational Fluid Dynamics Simulation and Experimental Verification

open access: yesHigh Voltage, EarlyView.
ABSTRACT The complex diffusion of characteristic gases within oil‐immersed transformers significantly influences the timeliness between the fault occurrence and gas detection. So far, the gas transport processes and spatio‐temporal distributions remain inadequately understood.
Chunpeng Li   +7 more
wiley   +1 more source

Pleiotropic Roles of FBXO11 in Tumorigenesis: Implications for Targeted Therapy

open access: yesCancer Science, EarlyView.
This complex comprises of scaffold CUL1, SKP1, RBX1 and FBXO11 receptor. The substrate is phosphorylated by specific kinase enzyme and recognized by the substrate recognition domain. FBXO11 targets numerous substrates for ubiquitination and degradation, FBXO11 substrates mainly include Snail, ZEB1, p53, BCL6, CDT2, CIITA, Cdc25a, hnRNPA2B1, SAMD1 and ...
Yuqi Zhang   +6 more
wiley   +1 more source

Ion Channel Dysfunction and Therapeutic Targeting in Salivary Gland Disorders

open access: yesOral Diseases, EarlyView.
ABSTRACT Objective Salivary gland hypofunction and xerostomia represent major clinical complications of radiation therapy, autoimmune disorders such as Sjögren's disease, and inherited epithelial ion transport defects. This review integrates current knowledge on ion channel dysfunction as a central mechanistic driver of salivary gland pathology and ...
Tarek Mohamed Abd El‐Aziz   +6 more
wiley   +1 more source

Optical Steering of Microbubbles for Nanoparticle Transport

open access: yes, 2016
Microbubbles are increasingly playing an important role in medicine and environmental waste management. In medicine, microbubbles coated with nanoparticles are being used for directed drug and gene delivery.
Krishnappa, Arjun
core   +1 more source

Scaling temporal resolution from mice to humans: Challenges and innovations in preclinical imaging of translational models

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Temporal scaling physiology differs significantly between mice and humans. Mice have higher metabolism, heart and respiratory rate, as well as faster blood flow rates, brain activity and physiological dynamics over time. These differences influence the temporal resolution needed in preclinical imaging of mouse models to ...
Sara Gargiulo, Matteo Gramanzini
wiley   +1 more source

Active Electromagnetic Interference Suppression for MRI and Proton Resonance Frequency Shift Thermometry During MRI‐Guided Microwave Ablation

open access: yesMagnetic Resonance in Medicine, Volume 96, Issue 4, Page 1572-1588, October 2026.
ABSTRACT Purpose To develop a software‐based active electromagnetic interference (EMI) suppression (AES) framework on whole‐body multi‐channel MRI systems for reliable MRI and MR thermometry during MRI‐guided microwave ablation (MWA). Methods In addition to primary imaging coils, an unloaded standard body array coil was positioned outside the imaging ...
Qing Dai   +5 more
wiley   +1 more source

Protocol of Noncontrast High-frequency Ultrasound and Contrast-enhanced Ultrasound-guided Lymphatic Mapping for Lymphaticovenous Anastomosis Surgery. [PDF]

open access: yesPlast Reconstr Surg Glob Open
Zhao C   +10 more
europepmc   +1 more source

Molecular Rotors: From Newtonian Fluids to Functional Materials as Viscosity and Temperature Sensing Tools

open access: yesAdvanced Functional Materials, Volume 36, Issue 72, 7 September 2026.
Molecular rotors are fluorescent molecules that are sensitive to viscosity and temperature variations in the environment. They exhibit a direct correlation between fluorescence and viscosity within Newtonian fluids. However, this correlation becomes less straightforward in complex systems.
Flavia Di Scala   +6 more
wiley   +1 more source

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