Results 121 to 130 of about 88,636 (324)

Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing (IWGT)

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.
Barbara L. Parsons, Marc A. Beal, Kerry L. Dearfield, George R. Douglas, Min Gi, B. Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Michelle Kenyon, Alexandra S. Long, David P. Lovell, Anthony M. Lynch, Meagan B. Myers, Stefan Pfuhler, Alisa Vespa, Andreas Zeller, George E. Johnson, Paul A. White   +17 more
wiley   +1 more source

Drug hypersensitivity caused by alteration of the MHC-presented self-peptide repertoire [PDF]

, 2012
Idiosyncratic adverse drug reactions are unpredictable, dose independent and potentially life threatening; this makes them a major factor contributing to the cost and uncertainty of drug development. Clinical data suggest that many such reactions involve
A. Lucas, A. M. English, A. Sette, A. Wriston, B. J. Grant, B. Peters, C. A. F. de Oliveira, C. Oseroff, Cahalan, Chessman, Chung, D. A. Ostrov, D. F. Hunt, Day, E. Phillips, Faletto, Friesner, H. M. Grey, H. Mei, Harndahl, J. Jakoncic, J. Shabanowitz, J. Sidney, Ko, L. Shi, L. Yang, Lavergne, M. Harndahl, Mallal, Martin, Melroy, Phillips, Pichler, Rudolph, S. Buus, S. Lu, S. Mallal, S. Southwood, Shastri, Shimizu, Sidney, Sidney, Tenzer, Udeshi, Y. A. Pompeu, Yang, Yang, Yewdell   +47 more
core   +4 more sources

Inherited metabolic epilepsies–established diseases, new approaches

Epilepsia Open, EarlyView.
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source

Ophthalmological findings in infants with microcephaly and presumable intra-uterus Zika virus infection.

Arquivos Brasileiros de Oftalmologia, 2016
PURPOSE In 2015, a twenty-fold increase in the prevalence of microcephaly in Brazil was reported, and the Ministry of Health associated this abnormal prevalence with the maternal-fetal Zika virus (ZIKV) transmission.
C. Ventura, M. Maia, B. Ventura, V. D. Linden, E. B. Araújo, R. Ramos, M. A. Rocha, M. D. Carvalho, R. Belfort, Liana O Ventura   +9 more
semanticscholar   +1 more source

Heterogeneous development of children with Congenital Zika Syndrome-associated microcephaly

, 2021
Juan P. Aguilar Ticona, Nívison Nery, Simon Doss-Gollin, Claudia Gambrah-Lyles, Millani Souza de Almeida Lessa, Valmir N. Rastely-Junior, Adriana Bona Matos, Bruno de Paula Freitas, Ana Borja, Elsio A. Wunder, Verena Ballalai, Carina Vieira, Jaqueline S. Cruz, Daiana de Oliveira, Danielle Bastos Araújo, Danielle Bruna Leal Oliveira, Denicar Lina Nascimento Fabris Maeda, Érica Araújo Mendes, Camila Pereira Soares, Edison Luíz Durigon, Luís Carlos de Souza Ferreira, Rubens Belfort, Antonio R.P. de Almeida, Jamary Oliveira‐Filho, Mitermayer Galvão dos Reis, Albert I. Ko, Federico Costa   +26 more
openalex   +2 more sources

Epilepsy syndromes classification

Epilepsia Open, EarlyView.
Abstract Epilepsy syndromes are distinct electroclinical entities which have been recently defined by the International League Against Epilepsy Nosology and Definitions Task Force. Each syndrome is associated with “a characteristic cluster of clinical and EEG features, often supported by specific etiologic findings”.
Elaine C. Wirrell, Nicola Specchio, Rima Nabbout, Phillip L. Pearl, Kate Riney   +4 more
wiley   +1 more source

Clinical Effect Analysis of Spinal Cord Electrical Stimulator Implantation for Diabetic Foot

Neuromodulation: Technology at the Neural Interface, EarlyView., 2021
Abstract Objective To investigate the clinical effect of spinal cord electrical stimulator implantation in the treatment of diabetic foot (DF). Materials and Methods We recruited 19 patients with DF who were admitted to Shengjing Hospital of China Medical University between January 2018 and May 2020.
Peng‐Bo Zhou, Min Bao
wiley   +1 more source

Mutations in WDR62 gene in Pakistani families with autosomal recessive primary microcephaly

BMC Neurology, 2011
Background Autosomal recessive primary microcephaly is a disorder of neurogenic mitosis that causes reduction in brain size. It is a rare heterogeneous condition with seven causative genes reported to date.
Mir Asif, Mahmood Saqib, Basit Sulman, Khan Bushra, Hassan Muhammad, Kousar Rizwana, Ahmad Wasim, Ansar Muhammad   +7 more
doaj   +1 more source

Mechanisms conferring sensitivity to low dose radiation exposure and consideration of potentially sensitivie individuals [PDF]

, 2009
No description ...
Jeggo, Penny
core  

Role of fetal MRI in the evaluation of isolated and non-isolated corpus callosum dysgenesis: results of a cross-sectional study [PDF]

, 2017
PURPOSE: The aims of this study were to characterize isolated and non-isolated forms of corpus callosum dysgenesis (CCD) at fetal magnetic resonance imaging (MRI) and to identify early predictors of associated anomalies.
Antonelli, Amanda, Bernardo, Silvia, Catalano, Carlo, DE VITO, Corrado, Di Meglio, L, Giancotti, Antonella, Manganaro, Lucia, Marchionni, Enrica, Pizzuti, Antonio, Saldari, Matteo, Silvestri, E, Vinci, Valeria   +11 more
core   +1 more source