Results 31 to 40 of about 67,545 (327)
Citron Kinase Deficiency Leads to Chromosomal Instability and TP53-Sensitive Microcephaly [PDF]
, 2017 Mutations in citron (CIT), leading to loss or inactivation of the citron kinase protein (CITK), cause primary microcephaly in humans and rodents, associated with cytokinesis failure and apoptosis in neural progenitors.
Alessandra Maria Adelaide, Chiotto +21 more
core +3 more sources
Feelings of mothers of infants with microcephaly: a qualitative study
Bioscience Journal, 2018 Microcephaly is a congenital malformation in which the brain does not develop properly. It can be the result of a series of factors, from malnutrition of the mother, drug abuse, infections during pregnancy, among others.
Cláudia Maria Sousa de Carvalho +10 more
doaj +3 more sources
The clinical diagnostic utility of array CGH in children with syndromic microcephaly
Annals of Indian Academy of Neurology, 2022 Background: A prospective study using array CGH in children with Syndromic microcephaly from a tertiary pediatric healthcare centre in India. Aim: To identify the copy number variations causative of microcephaly detected through chromosomal array CGH ...
Manisha Goyal +4 more
doaj +1 more source
Cost-effectiveness of a potential Zika vaccine candidate: a case study for Colombia [PDF]
, 2018 Background: A number of Zika vaccine platforms are currently being investigated, some of which have entered clinical trials. We sought to evaluate the cost-effectiveness of a potential Zika vaccine candidate under the WHO Vaccine Target Product Profile ...
Moghadas, Seyed +2 more
core +2 more sources
Viruses, 2023 Congenital Zika Syndrome (CZS) is associated with an increased risk of microcephaly in affected children. This study investigated the peripheral dysregulation of immune mediators in children with microcephaly due to CZS.
Wallace Pitanga Bezerra +10 more
doaj +1 more source
Zika virus: New clinical syndromes and its emergence in the western hemisphere [PDF]
, 2016 Zika virus (ZIKV) had remained a relatively obscure flavivirus until a recent series of outbreaks accompanied by unexpectedly severe clinical complications brought this virus into the spotlight as causing an infection of global public health concern.
Brazilian Medical Genetics Society–Zika Embryopathy Task Force +9 more
core +3 more sources
Microcephaly epidemic related to the Zika virus and living conditions in Recife, Northeast Brazil
BMC Public Health, 2018 Background Starting in August 2015, there was an increase in the number of cases of neonatal microcephaly in Northeast Brazil. These findings were identified as being an epidemic of microcephaly related to Zika virus (ZIKV) infection.
Wayner Vieira de Souza +13 more
doaj +1 more source
A developmental and genetic classification for malformations of cortical development: update 2012. [PDF]
, 2012 Malformations of cerebral cortical development include a wide range of developmental disorders that are common causes of neurodevelopmental delay and epilepsy. In addition, study of these disorders contributes greatly to the understanding of normal brain
Barkovich, A James +4 more
core +3 more sources
Viruses, 2021 It was late 2015 when Northeast Brazil noticed a worrying increase in neonates born with microcephaly and other congenital malformations. These abnormalities, characterized by an abnormally small head and often neurological impairment and later termed ...
Evangelia Antoniou +8 more
doaj +1 more source
How do medical researchers make causal inferences? [PDF]
, 2019 Bradford Hill (1965) highlighted nine aspects of the complex evidential situation a medical researcher faces when determining whether a causal relation exists between a disease and various conditions associated with it.
Dammann, Olaf +2 more
core +1 more source