Results 51 to 60 of about 90,161 (348)

Human-Specific Genes, Cortical Progenitor Cells, and Microcephaly

Cells, 2021
Over the past few years, human-specific genes have received increasing attention as potential major contributors responsible for the 3-fold difference in brain size between human and chimpanzee.
M. Heide, W. Huttner
semanticscholar   +1 more source

Feelings of mothers of infants with microcephaly: a qualitative study

Bioscience Journal, 2018
Microcephaly is a congenital malformation in which the brain does not develop properly. It can be the result of a series of factors, from malnutrition of the mother, drug abuse, infections during pregnancy, among others. In the family context, the birth
Cláudia Maria Sousa de Carvalho, Antônio Adeilson Mendes Pereira, Geany Ferreira de Abreu, Lourena Joyce Matos Paz, Lydia de Carvalho Pires, Camila Aparecida Pinheiro Landim Almeida, Fernanda Cláudia Miranda Amorim, Magda Coeli Vitorino Sales Coêlho, Adélia Dalva da Silva Oliveira, Ana Raquel Batista de Carvalho, Guilherme Guarino de Moura Sá   +10 more
doaj   +3 more sources

Zika virus infection, associated microcephaly, and low yellow fever vaccination coverage in Brazil: is there any causal link?

Journal of Infection in Developing Countries, 2016
Introduction: Since the end of 2014, Zika virus (ZIKV) infection has been rapidly spreading in Brazil. Methodology: To analyze the possible association of yellow fever vaccine with a protective effect against ZIKV-related microcephaly, the following ...
Luciano Pamplona de Góes Cavalcanti, Pedro Luiz Tauil, Carlos Henrique Alencar, Wanderson Oliveira, Mauro Martins Teixeira, Jorg Heukelbach   +5 more
doaj   +1 more source

Mutations in pericentrin cause Seckel syndrome with defective ATR-dependent DNA damage signaling [PDF]

, 2007
Large brain size is one of the defining characteristics of modern humans. Seckel syndrome (MIM 210600), a disorder of markedly reduced brain and body size, is associated with defective ATR-dependent DNA damage signaling.
A Kramer, A Purohit, Anand Saggar, Andrew P Jackson, Ben Hamel, Bertrand Vernay, C Ponting, Carol-Anne Martin, CG Woods, D Chen, D Diviani, Elen Griffith, F Majewski, F Ruschendorf, GK Alderton, GK Alderton, H Dodson, H Loffler, H Niida, HPG Seckel, J Bond, J Bond, JB Dictenberg, K Miyoshi, M Martinez-Campos, M O'Driscoll, Mark O'Driscoll, MR Flory, Nouriya Al Sanna, P Brown, Paola Vagnarelli, Penny A Jeggo, Q Li, RD Martin, S Doxsey, S Sengupta, S Zhang, Sarah Walker, SJ Doxsey, Tom Stiff, WC Zimmerman, William C Earnshaw, Y Shiloh   +42 more
core   +4 more sources

In vivo imaging of Zika virus reveals dynamics of viral invasion in immune-sheltered tissues and vertical propagation during pregnancy [PDF]

, 2020
Rationale: Zika virus (ZIKV) is a pathogenic virus known to cause a wide range of congenital abnormalities, including microcephaly, Guillain-Barre syndrome, meningoencephalitis, and other neurological complications, in humans. This study investigated the
Hu, Q, Ke, X, Li, P, Liu, Y, Luo, D, Miao, Y, Sun, J, Tan, Z, Wang, H, Wang, T, Xu, F, Zhang, Y, Zheng, Z   +12 more
core   +1 more source

The clinical diagnostic utility of array CGH in children with syndromic microcephaly

Annals of Indian Academy of Neurology, 2022
Background: A prospective study using array CGH in children with Syndromic microcephaly from a tertiary pediatric healthcare centre in India. Aim: To identify the copy number variations causative of microcephaly detected through chromosomal array CGH ...
Manisha Goyal, Mohammed Faruq, Ashok Gupta, Divya Shrivastava, Uzma Shamim   +4 more
doaj   +1 more source

Experimental Zika Virus Infection in the Pregnant Common Marmoset Induces Spontaneous Fetal Loss and Neurodevelopmental Abnormalities. [PDF]

, 2018
During its most recent outbreak across the Americas, Zika virus (ZIKV) was surprisingly shown to cause fetal loss and congenital malformations in acutely and chronically infected pregnant women.
Aagaard, Kjersti M, Castro, Eumenia CC, Chiu, Charles Y, Giavedoni, Luis, Hodara, Vida L, Layne-Colon, Donna, Li, Tony, Martyn, Calla, Parodi, Laura M, Patterson, Jean L, Reyes, Kevin, Rutherford, Julienne, Seferovic, Maxim, Suter, Melissa A, Sánchez-San Martín, Claudia, Tamhankar, Manasi, Tardif, Suzette D, Yagi, Shigeo   +17 more
core   +2 more sources

YIPF5 mutations cause neonatal diabetes and microcephaly through endoplasmic reticulum stress

Journal of Clinical Investigation, 2020
Neonatal diabetes is caused by single gene mutations reducing pancreatic β cell number or impairing β cell function. Understanding the genetic basis of rare diabetes subtypes highlights fundamental biological processes in β cells.
E. De Franco, Maria Lytrivi, Hazem Ibrahim, H. Montaser, M. Wakeling, Federica Fantuzzi, K. Patel, Céline Demarez, Ying Cai, M. Igoillo-Esteve, C. Cosentino, Väinö Lithovius, H. Vihinen, E. Jokitalo, T. Laver, Matthew B. Johnson, Toshiaki Sawatani, H. Shakeri, Nathalie Pachera, B. Haliloglu, M. Ozbek, Edip Unal, Ruken Yıldırım, Tushar Godbole, M. Yıldız, B. Aydin, Angéline Bilheu, Ikuo K. Suzuki, S. Flanagan, P. Vanderhaeghen, V. Senée, C. Julier, P. Marchetti, D. Eizirik, S. Ellard, J. Saarimäki-Vire, T. Otonkoski, M. Cnop, A. Hattersley   +38 more
semanticscholar   +1 more source

Low CCL2 and CXCL8 Production and High Prevalence of Allergies in Children with Microcephaly Due to Congenital Zika Syndrome

Viruses, 2023
Congenital Zika Syndrome (CZS) is associated with an increased risk of microcephaly in affected children. This study investigated the peripheral dysregulation of immune mediators in children with microcephaly due to CZS.
Wallace Pitanga Bezerra, Amanda Costa Ayres Salmeron, Anna Cláudia Calvielli Castelo Branco, Ingryd Camara Morais, Valéria Soraya de Farias Sales, Paula Renata Lima Machado, Janeusa Trindade Souto, Josélio Maria Galvão de Araújo, Paulo Marcos da Matta Guedes, Maria Notomi Sato, Manuela Sales Lima Nascimento   +10 more
doaj   +1 more source

How do medical researchers make causal inferences? [PDF]

, 2019
Bradford Hill (1965) highlighted nine aspects of the complex evidential situation a medical researcher faces when determining whether a causal relation exists between a disease and various conditions associated with it.
Dammann, Olaf, Poston, Ted, Thagard, Paul   +2 more
core   +1 more source