Results 11 to 20 of about 2,105 (179)

Chaperone mediated detection of small molecule target binding in cells

Nature Communications, 2020
Quantitative profiling of small molecule-protein binding in cells can aid basic biochemical research and drug discovery. Here, the authors develop the Heat Shock Protein Inhibition Protein Stability Assay (HIPStA) as a high-throughput method to assess ...
Kelvin F. Cho, Taylur P. Ma, Christopher M. Rose, Donald S. Kirkpatrick, Kebing Yu, Robert A. Blake   +5 more
doaj   +1 more source

Antibody toolkit reveals N-terminally ubiquitinated substrates of UBE2W

Nature Communications, 2021
UBE2W catalyzes the ubiquitination of protein N-termini but its substrate spectrum is largely unknown. Here, the authors discover mAbs selective for peptides derived from N-terminally ubiquitinated proteins, solve the structure of a peptide-bound mAb and
Christopher W. Davies, Simon E. Vidal, Lilian Phu, Jawahar Sudhamsu, Trent B. Hinkle, Scott Chan Rosenberg, Frances-Rose Schumacher, Yi Jimmy Zeng, Carsten Schwerdtfeger, Andrew S. Peterson, Jennie R. Lill, Christopher M. Rose, Andrey S. Shaw, Ingrid E. Wertz, Donald S. Kirkpatrick, James T. Koerber   +15 more
doaj   +1 more source

Contrasting population genomic structuring of northern pike (Esox lucius L.) in fresh- and brackish water environments: Implications for management and conservation. [PDF]

J Fish Biol
Abstract Understanding the factors that shape population genetic structure is crucial for advancing evolutionary studies and developing effective management and conservation strategies. The northern pike (Esox lucius L.) is a top teleost predator that inhabits fresh and brackish water environments in the northern hemisphere.
Diaz-Suarez A, López ME, Sundblad G, Vasemägi A.   +3 more
europepmc   +2 more sources

Revealing Population Connectivity of the Estuarine Tapertail Anchovy Coilia nasus in the Changjiang River Estuary and Its Adjacent Waters Using Otolith Microchemistry

Fishes, 2022
The estuarine tapertail anchovy, Coilia nasus, is a migratory fish with high economic value in China. We collected fish from the Changjiang River (the Yangtze River) estuary, the Qiantang River estuary, and the southern Yellow Sea, and studied their ...
Tao Jiang, Hongbo Liu, Yuhai Hu, Xiubao Chen, Jian Yang   +4 more
doaj   +1 more source

Taste Attributes of the “June Hairy Crab” Juveniles of Chinese Mitten Crab (Eriocheir sinensis) in Yangcheng Lake, China—A Pilot Study

Fishes, 2022
This is the first report on the use of a taste sensing system to quantitatively evaluate the taste attributes of two groups of native “June hairy crab” juveniles (commonly referred to as “Liu-Yue-Huang”) of the Chinese mitten crab (Eriocheir Sinensis H ...
Hongbo Liu, Junren Xue, Jing Tang, Tao Jiang, Xiubao Chen, Jian Yang   +5 more
doaj   +1 more source

Polarized microtubule remodeling transforms the morphology of reactive microglia and drives cytokine release

Nature Communications, 2023
Microglial reactivity is a pathological hallmark in many neurodegenerative diseases. During stimulation, microglia undergo complex morphological changes, including loss of their characteristic ramified morphology, which is routinely used to detect and ...
Max Adrian, Martin Weber, Ming-Chi Tsai, Caspar Glock, Olga I. Kahn, Lilian Phu, Tommy K. Cheung, William J. Meilandt, Christopher M. Rose, Casper C. Hoogenraad   +9 more
doaj   +1 more source

Evaluating Complex Magma Mixing via Polytopic Vector Analysis (PVA) in the Papagayo Tuff, Northern Costa Rica: Processes that Form Continental Crust

Geosciences, 2013
Over the last forty years, research has revealed the importance of magma mixing as a trigger for volcanic eruptions, as well as its role in creating the diversity of magma compositions in arcs.
Guillermo E. Alvarado, Thomas A. Vogel, Lina C. Patino, David W. Szymanski   +3 more
doaj   +1 more source

Otolith Microchemistry Reveals Life History and Habitat Use of Coilia nasus from the Dayang River of China

Fishes, 2022
The estuarine tapertail anchovy Coilia nasus is distributed throughout the Dayang River. However, the life history and habitat use of this fish remain unknown. Here, the microchemistry patterns of Sr and Ca in 23 otoliths collected from the lower reaches
Yuhai Hu, Tao Jiang, Hongbo Liu, Xiubao Chen, Jian Yang   +4 more
doaj   +1 more source

Spatial changes in trace element and strontium isotope water chemistry in a temperate river system with application to sturgeon movement

Journal of Freshwater Ecology, 2019
Understanding patterns in trace element concentrations and water quality within river systems provides a foundation to evaluate retrospective movements and habitat use of fish.
Mackenzie A. Gunn, Zachary S. Moran, Brenda M. Pracheil, Peter J. Allen   +3 more
doaj   +1 more source

Inter-Otolith Differences in Strontium Markings: A Case Study on the Juvenile Crucian Carp Carassius carassius (Linnaeus, 1758)

Fishes, 2022
The release of hatchery-reared fish fry for restocking is important for the enrichment of fishery resources; however, the effective evaluation of the success rate of marking such fish is challenging. We exposed juvenile crucian carp (Carassius carassius)
Yahua Zhu, Tao Jiang, Xiubao Chen, Hongbo Liu, Quinton Phelps, Jian Yang   +5 more
doaj   +1 more source