Results 41 to 50 of about 4,122 (215)

Lumbar microdiscectomy with the simply modified taylor retractor [PDF]

, 2021
Aim: To describe the modifications we made to the Taylor retractor (TR) used in routine spinal surgery and present the results of cases that underwent surgery with the modified TR. Materials and Methods: We made two basic modifications to the TR used in
Cetinkal, Ahmet
core   +3 more sources

SETD1A Regulates Glycolysis and Senescence of Nucleus Pulposus Cells via H3K4me3–HELZ2/PPARα‐HIF1α Axis to Drive Intervertebral Disc Degeneration

Advanced Science, Volume 13, Issue 34, 19 June 2026.
SETD1A is a key epigenetic regulator in NPCs during IDD. In normal NPCs, it sustains H3K4me3–HELZ2/PPARα–HIF1α signaling to maintain glycolytic energy metabolism and proliferation. In degenerated NPCs, reduced SETD1A disrupts this axis, impairing glycolysis and accelerating senescence, highlighting a promising therapeutic target for IDD.
Jiawei Fu, Xue Leng, Jiang Long, Zhengao Liao, Xiaoqin An, Xuezheng Ai, Dan Long, Changqing Li, Bo Huang, Yue Zhou, Shiwu Dong, Chencheng Feng   +11 more
wiley   +1 more source

Anxiety, fears and fear-avoidance beliefs and therapeutic outcome after lumbar microdiscectomy

Acta Clinica Croatica
Microdiscectomy is one of the surgical methods for the treatment of herniated intervertebral disc in patients with low back pain. The aim of the research was to evaluate the presence of psychological and cognitive-behavioral factors, including anxiety,
Slobodan Pantelinac, Dušica Simić-Panić, Gordana Devečerski, Snežana Tomašević Todorović   +3 more
doaj   +1 more source

The long-term outcome of revision microdiscectomy for recurrent sciatica [PDF]

PurposeTo study the long-term outcome of revision microdiscectomy after classic microdiscectomy for lumbosacral radicular syndrome (LSRS).MethodsEighty-eight of 216 patients (41%) who underwent a revision microdiscectomy between 2007 and 2010 for MRI ...
Bouma, G.J., Verbaan, D., Schuurman, P.R., Tasche, S., Peul, W.C., Lequin, M.B., Vandertop, W.P.   +6 more
core   +1 more source

Patients With Chronic Low Back Pain Without Advanced Disk Degeneration Exhibit Gut Microbiome Dysbiosis: Evidence From an Age‐, Sex‐, and BMI‐Matched Pilot Study

JOR SPINE, Volume 9, Issue 2, June 2026.
Chronic low back pain in patients without advanced disc degeneration is associated with gut microbiome dysbiosis, marked by reduced microbial diversity and altered bacterial composition. These findings support a gut–disk axis in which impaired gut barrier integrity and systemic inflammation may contribute to disc inflammation, nociceptive fiber ...
Stone Sima, Thomas Jeffries, Alisha Sial, Suhani Sharma, Neha Chopra, Fan Zhang, Georgina Hold, Wentian Li, Ji Tu, Victor Chen, Ashish Diwan   +10 more
wiley   +1 more source

Efficacy and Safety of the Use of Interspinous Spacers in the Treatment of Lumbar Spinal Stenosis: Mapping Gap and Scoping Review

Pain Practice, Volume 26, Issue 5, June 2026.
ABSTRACT Objectives Low back pain is a common pathology in the general population. In people over 60 years of age, it is associated with degenerative changes that cause narrowing of the vertebral canal. Its treatment includes conservative measures and even surgery with decompression and fusion.
Juan Carlos Acevedo‐Gonzalez, Valentina Velasco‐Muñoz, Juan Jacobo Ramirez‐Triana, Danuby Adriana Buitrago‐Lopez   +3 more
wiley   +1 more source

The first experience of autologous chondrocytes transplantation after lumbar microdiscectomy

, 2014
The purpose. To develop and provide into clinical practice the hi-tech method of autologous chondrocytes transplantation for treatment of patients with intervertebral discs herniation after lumbar microdiscectomy.Material and methods.
Volodymyr Shabliy, Yuriy Pedachenko, Elena Krasilenko, Eugene Pedachenko, Kostyantyn Gorbatyuk, Mykhaylo Khyzhnyak   +5 more
core   +1 more source

Unraveling Chronic Pain: From Mechanisms and Risks to Diagnosis and Treatment

MedComm, Volume 7, Issue 4, April 2026.
Chronic pain arises through distinct molecular pathways categorized into nociceptive, neuropathic, and nociplastic types. Nociceptive pain begins with TRP channel activation in peripheral nociceptors, signaling via Aδ‐ and C‐fibers through the spinal dorsal horn and spinothalamic tracts to the brain, regulated by descending inhibition and involving ...
Xiaofeng Dai, Chongxiang Wang, Ping Jiang, Xiaopeng Mei   +3 more
wiley   +1 more source

Unilateral Biportal Endoscopic Discectomy Versus Microscopic Discectomy In Single Level Lumbar Disc Prolapse

Minia Journal of Medical Research
Background: Lumbar disc herniation is a common cause of lower back pain and radiculopathy. Both Unilateral Biportal Endoscopic (UBE) discectomy and microdiscectomy are established surgical techniques for treatment.
Mohamed El-Heeny, fouad fouad, mohamed Kamel, Ahmed Moawad   +3 more
doaj   +1 more source

What Do Patients Want to Know? Determining the Information Needs of Patients Undergoing Lumbar Microdiscectomy [PDF]

, 2010
Background: No spine-specific educational tool has been developed using input from all relevant stakeholders, including patients. Purpose: The objective of this study was to determine the information needs of lumbar microdiscectomy patients.
Zahrai, Ali
core   +1 more source