Results 151 to 160 of about 52,627 (301)

Inhibition of late sodium current prevents pathological hyperactivation of calcium/calmodulin‐dependent protein kinase IIδ in a murine model of acute doxorubicin‐related cardiotoxicity

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Doxorubicin (DOX) is a highly effective anthracycline, whose clinical application for cancer is limited by cardiotoxicity. The mechanisms underlying doxorubicin‐induced toxic cardiomyopathy (DICM) involve electrophysiological remodelling with intracellular Na+ overload because of increased late INa and hyperactivation of
Anna‐Lena Feder, Anna‐Maria Pfützenreuter, Lea Maria Funke, Maria Johanna Baier, Daniel Tarnowski, Laura Stengel, Lars Siegfried Maier, Can Martin Sag   +7 more
wiley   +1 more source

Adaptive personalization for wearable non-invasive continuous glucose sensors. [PDF]

Nat Commun
Yao C, Gao L, Wang X, Wang H, Huang S, Li G, Han X, Yang H, Liu Z, Liang S, Yun P, Wang Y, Cai Y, Zhang P, Wu Y, Li M, Wang J, Chen HJ, Huang X, Xie X.   +19 more
europepmc   +1 more source

Self-Assembled Monolayers on Gold Surfaces of Ferrocene-BODIPY-Fullerene-Helical Peptide Conjugates: Studies of Electron Transfer Processes by Ultra-Fast Electrochemistry. [PDF]

J Pept Sci
Three ferrocene‐BODIPY‐C60‐peptides (T1–T3) were synthesized and grafted on gold surfaces to form self‐assembled monolayers. Calculation of the tilt angles and surface density of these SAMs using PM‐IRRAS and ultrafast electrochemical experiments revealed that less vertically oriented and densely packed monolayers were obtained compared with previously
Rabah J, Vallée A, Fensterbank H, Ha-Thi MH, Méallet R, Boujday S, Maisonhaute E, Wright K, Allard E.   +8 more
europepmc   +2 more sources

Crossing subfamily borders: Mechanosensitive TREK‐1 and alkaline‐activated TASK‐4 form heterodimers with unique functional and pharmacological properties

British Journal of Pharmacology, EarlyView.
Background and Purpose The tandem of two‐pore‐domain potassium (K2P) channels TREK‐1 and TASK‐4 are expressed in the heart and pancreatic beta‐cells. As TREK‐1 and TASK‐4 belong to distinct subfamilies with different functional hallmarks, heteromerization of these two channels was highly unexpected.
Sven Schütte, Florian Schick, Emilia De Martino, Hannah Schmitz, Katharina E. S. Zander, Franziska Holz, Patrick Sauer, Luise Mildeberger, Moritz Linder, Axel Loewe, Aytug K. Kiper, Silke Kauferstein, Martin K.‐H. Schäfer, Susanne Rinné, Niels Decher   +14 more
wiley   +1 more source

Simple, Fast and Sensitive Voltammetric Procedure for Copper Ion Determination Using a Solid Gold Microelectrode Array. [PDF]

Sensors (Basel)
Korolczuk M, Ochab M, Gęca I.
europepmc   +1 more source

Investigation of the mechanisms and modulation of irinotecan‐induced emesis in Suncus murinus

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Irinotecan is a widely used chemotherapeutic agent that frequently causes nausea and emesis. Its emetic mechanism of action is poorly understood and the choice of drugs to reduce nausea and emesis is largely empirical. Experimental Approach Using Suncus murinus, we examined (i) the dose–response and temporal profile of ...
Zengbing Lu, Julia Y. H. Liu, Yasuhiro Nakagami, Zitong Li, Xiaofei Huang, Man P. Ngan, Dexuan Cui, John A. Rudd   +7 more
wiley   +1 more source

Potential feasibility of a novel over‐the‐wire microelectrode catheter for recording coronary sinus electrograms in patients with cardiac resynchronization therapy devices

Journal of Arrhythmia, 2023
Masato Okada, Naoko Miyazaki, Koji Tanaka, Yusuke Ikada, Nobuaki Tanaka   +4 more
doaj   +1 more source

A Dual-Mode Neural Amplifier Array for Biopotential and FSCV-Based Neurochemical Measurements. [PDF]

Biosensors (Basel)
Crocker MA, White KA, Darroudi M, Bapanapalli VSS, Lipscomb CS, John BS, Kim BN.   +6 more
europepmc   +1 more source

Deep brain stimulation outcomes and management of childhood‐onset dystonia and associated hyperkinetic movements disorders

Developmental Medicine &Child Neurology, EarlyView.
Abstract Aim To examine longitudinal changes in self‐selected goals and dystonia severity over 1 year, 2 years, and 5 years after deep brain stimulation (DBS) in children and young people (CYP) with dystonia and other hyperkinetic movement disorders, using CYP and caregiver reports.
Sinead Barkey, Laura Ainaga, Eva Maria Navarrete Muñoz, Verity McClelland, Keyoumars Ashkan, Richard Selway, Harutomo Hasegawa, Daniel E Lumsden, Jean‐Pierre Lin, Hortensia Gimeno   +9 more
wiley   +1 more source

Single-neuron responses to neurostimulation: Insights for epilepsy. [PDF]

Neurotherapeutics
Cowan RL, Merricks EM, Davis TS, Rolston JD, Rahimpour S, Shofty B, Schevon CA, Smith EH.   +7 more
europepmc   +1 more source