Results 91 to 100 of about 9,812 (246)
Lipid Nanoparticles in Drug Delivery: Overcoming Challenges and Unlocking New Frontiers
Small Structures, Volume 7, Issue 3, March 2026.Lipid nanoparticles (LNPs) have revolutionized nucleic acid delivery, yet challenges in formulation, stability, and targeted efficacy persist. This review explores how advances in microfluidic manufacturing, precision targeting, and endosomal escape are reshaping LNP design.
Jordan Kambanis +7 more
wiley +1 more source
A Novel DC Electroosmotic Micromixer Based on Helical Vortices
ActuatorsThis work introduces a novel direct current electroosmosis (DCEO) micromixer designed for rapid and efficient fluid mixing. This micromixer demonstrates excellent capability, achieving approximately 98.5% mixing efficiency within a one-second timespan ...
Sri Manikandan Saravanakumar +3 more
doaj +1 more source
, 2022 In this project, we aimed at using machine learning to generate models capable of predicting the mixing index and the pressure drop that occurs in various geometries of 3D micromixers, working at any Reynolds numbers between 1 to 100. These conditions were deemed optimal to ensure the laminar flow profile desired. To achieve this intelligent design, we
Castro Dominguez, Bernardo +5 more
openaire +1 more source
Drug Product Development of Lipid Nanoparticle‐Based mRNA Therapeutics and Vaccines
WIREs Nanomedicine and Nanobiotechnology, Volume 18, Issue 2, March/April 2026.Overview of the development path from an mRNA–lipid nanoparticle (LNP) concept to a licensed drug product, covering LNP design, manufacturing process development, formulation, and analytical characterization. ABSTRACT Lipid nanoparticles (LNP) are currently the most relevant non‐viral delivery systems for mRNA and occasionally for smaller nucleic acids
Gideon Kersten +4 more
wiley +1 more source
Ice Lithography: Recent Progress Opens a New Frontier of Opportunities
Advanced Functional Materials, Volume 36, Issue 12, 9 February 2026.This review focuses on recent advancements in ice lithography, including breakthroughs in compatible precursors and substrates, processes and applications, hardware, and digital methods. Moreover, it offers a roadmap to uncover innovation opportunities for ice lithography in fields such as biological, nanoengineering and microsystems, biophysics and ...
Bingdong Chang +9 more
wiley +1 more source
Lagrangian Transport Through Surfaces in Compressible Flows
, 2017 A material-based, i.e., Lagrangian, methodology for exact integration of flux by volume-preserving flows through a surface has been developed recently in [Karrasch, SIAM J. Appl. Math., 76 (2016), pp. 1178-1190]. In the present paper, we first generalize
Hofherr, Florian, Karrasch, Daniel
core +1 more source
Optimized Simulation and Validation of Particle Advection in Asymmetric Staggered Herringbone Type Micromixers [PDF]
, 2014 This paper presents and compares two different strategies in the numerical simulation of passive microfluidic mixers based on chaotic advection. In addition to flow velocity field calculations, concentration distributions of molecules and trajectories of
Fürjes, Péter +3 more
core +2 more sources
Advanced Science, Volume 13, Issue 10, 18 February 2026.Netrin‐1 expression is upregulated in hepatic stellate cells (HSCs) during metabolic dysfunction–associated steatohepatitis and injury‐mediated liver fibrosis. Secreted Netrin‐1 establishes an autocrine positive feedback loop by binding to UNC5B receptors on HSCs.
Jiahui Zhao +8 more
wiley +1 more source
Optimization Design of a Novel Passive Micromixer Using Response Surface Methodology [PDF]
Iranian Journal of Chemistry & Chemical EngineeringBiochips and microchemical systems utilize micromixers to mix various reactants in microscale environments effectively. The innovative microfluidic device is described. This study aims to enhance the Mixing Index (MI) by changing geometric parameters and
Ke Wang
doaj +1 more source
Numerical optimization of passive chaotic micromixers [PDF]
, 2011 This paper was presented at the 3rd Micro and Nano Flows Conference (MNF2011), which was held at the Makedonia Palace Hotel, Thessaloniki in Greece.
3rd Micro and Nano Flows Conference (MNF2011) +3 more
core