Results 301 to 310 of about 124,795 (370)

Association of PD-L1 positivity with Epstein Barr virus infection and microsatellite instability in gastric carcinomas with lymphoid stroma. [PDF]

Sci Rep
Lee SM, Oh H.
europepmc   +1 more source

Novel SOX17 frameshift mutations in endometrial cancer are functionally distinct from recurrent missense mutations. [PDF]

, 2017
Cohn, David E, Goodfellow, Paul J, Kurita, Takeshi, Miranda, Mario A, Mutch, David G, O\u27Hern, Matthew J, Sapp, Caroline E, Serna, Vanida A, Walker, Christopher J   +8 more
core   +1 more source

Impact of molecular diagnostics and targeted cancer therapy on patient outcomes (MODIFY): a retrospective study of the implementation of precision oncology

Molecular Oncology, Volume 19, Issue 5, Page 1508-1516, May 2025.
The authors conducted a retrospective study of 94 patients with advanced cancer who underwent next‐generation sequencing (NGS) gene panel analysis and received targeted treatments when applicable. Results further support evidence indicating that molecular profiling provides clinical benefit.
Michaël Dang, Anna Schritz, Nikolai Goncharenko, Guy Berchem   +3 more
wiley   +1 more source

Association between somatic microsatellite instability, hypermutation status, and specific T cell subsets in colorectal cancer tumors. [PDF]

Front Immunol
Thomas CE, Takashima Y, Wesselink E, Ugai T, Steinfelder RS, Buchanan DD, Qu C, Hsu L, Dias Costa A, Gallinger S, Grant RC, Huyghe JR, Thomas SS, Ogino S, Phipps AI, Nowak JA, Peters U.   +16 more
europepmc   +1 more source

Investigation of three alternative histopathological scoring methods at the invasive tumour front in colorectal cancer

The Journal of Pathology: Clinical Research, Volume 11, Issue 3, May 2025.
Abstract Although the characteristics at the invasive tumour front in colorectal cancer (CRC) are simple to assess, they are not included in routine pathology reports because they lack reproducibility and standardisation. In this study, we aimed to validate alternative scoring methods at the invasive tumour front in a large cohort of stage I–III CRC ...
Walaiphorn Woraharn, Ashley McCulloch, Christopher Bigley, Phimmada Hatthakarnkul, Kathryn Pennel, Peter Alexander, Hester van Wyk, Antonia Roseweir, Jennifer Hay, Noori Maka, James Park, Nigel B Jamieson, Joanne Edwards, Campbell SD Roxburgh   +13 more
wiley   +1 more source

A deep multiple instance learning framework improves microsatellite instability detection from tumor next generation sequencing. [PDF]

Nat Commun
Ziegler J, Hechtman JF, Rana S, Ptashkin RN, Jayakumaran G, Middha S, Chavan SS, Vanderbilt C, DeLair D, Casanova J, Shia J, DeGroat N, Benayed R, Ladanyi M, Berger MF, Fuchs TJ, Brannon AR, Zehir A.   +17 more
europepmc   +1 more source

A Copper‐Based Photothermal‐Responsive Nanoplatform Reprograms Tumor Immunogenicity via Self‐Amplified Cuproptosis for Synergistic Cancer Therapy

Advanced Science, Volume 12, Issue 19, May 22, 2025.
This study introduces cuproptosis nanoplatform, a novel nanoplatform using Cu2−XS hollow nanospheres, elesclomol, and lauric acid (LA) for self‐amplified cuproptosis. NIR‐II laser activation melts LA, releasing copper ions and elesclomol to enhance copper delivery within tumor cells, reduce glutathione's inhibitory effect, and trigger immunogenic cell ...
Runzi Cheng, Zhenhao Li, Weican Luo, Hongwu Chen, Tingting Deng, Zhenqi Gong, Qing Zheng, Baizhi Li, Yongming Zeng, Huaiming Wang, Cong Huang   +10 more
wiley   +1 more source

Microsatellite Instability Testing and Prognostic Implications in Colorectal Cancer. [PDF]

Cancers (Basel)
Ho V, Chung L, Wilkinson K, Ma Y, Rutland T, Lea V, Lim SH, Abubakar A, Ng W, Lee M, Roberts TL, Becker TM, Mackenzie S, Chua W, Lee CS.   +14 more
europepmc   +1 more source

Methionine Metabolism Dictates PCSK9 Expression and Antitumor Potency of PD‐1 Blockade in MSS Colorectal Cancer

Advanced Science, Volume 12, Issue 19, May 22, 2025.
This study establishes a mechanistic link between amino acid metabolism and cholesterol metabolism within the tumor microenvironment. Mechanistically, methionine is catabolized to S‐adenosyl‐methionine (SAM) to promote the transcription of PCSK9, a key orchestrator of cholesterol metabolism, via DNMT1‐mediated DNA methylation and suppressing SIRT6 ...
Qi‐Long Wang, Zijie Chen, Xiaofei Lu, Huizhen Lin, Huolun Feng, Nuozhou Weng, Liwen Chen, Mengnan Liu, Li Long, Lingjun Huang, Yongmei Deng, Kehong Zheng, Xiaojun Zheng, Yong Li, Ting Cai, Jiabin Zheng, Wei Yang   +16 more
wiley   +1 more source

Detecting microsatellite instability by length comparison of microsatellites in the 3' untranslated region with RNA-seq. [PDF]

Brief Bioinform
Choi JW, Lee JO, Lee S.
europepmc   +1 more source