Results 151 to 160 of about 2,794,950 (328)

The cochaperone BAG3 promotes the stabilization of p53 under heat stress conditions

open access: yesFEBS Open Bio, EarlyView.
Under heat stress, BAG3 translocates to the nucleus and forms a complex with Hsp70 and p53, thereby promoting p53 stabilization and enhancing its transcriptional activity. These findings suggest that BAG3 functions as a cochaperone that supports p53‐mediated stress responses in cooperation with Hsp70.
Ngoc Nguyen Thi Minh   +2 more
wiley   +1 more source

Application of exoscope for resection of parasagittal meningioma

open access: yes陆军军医大学学报
Objective To investigate the application of exoscope in resection of parasagittal meningioma. Methods A retrospective analysis was conducted on 50 patients with parasagittal meningioma undergoing surgical treatment in a same medical group of our ...
CHEN Yong, ZHENG Xin, ZHANG Xiaoqing
doaj   +1 more source

Menthol‐like cooling compounds, including (R)‐(‐)‐carvone, inhibit the human bitter taste receptors for saccharin and acesulfame K

open access: yesFEBS Open Bio, EarlyView.
We report that some menthol‐like cooling compounds, including (R)‐(‐)‐carvone, act as inhibitors of TAS2R31 and TAS2R43, which are taste receptors responsible for the intrinsic bitter aftertastes of saccharin and acesulfame K. However, there was little correlation between the intensity of the cooling sensation and the potency of bitterness inhibition ...
Miyuu Saito, Takumi Misaka
wiley   +1 more source

Downregulation of sST2, a decoy receptor for interleukin‐33, enhances subcutaneous tumor growth in murine pancreatic cancer cells

open access: yesFEBS Open Bio, EarlyView.
Subcutaneous implantation of murine Panc02 pancreatic cancer cells depleted of sST2, a soluble decoy receptor for the proinflammatory interleukin‐33 (IL‐33), leads to a decreased number of GLUT4‐positive cancer‐associated adipocytes, reduced levels of the anti‐inflammatory molecule adiponectin, increased phosphorylation of IκBα, elevated Cxcl3 ...
Miho Akimoto   +5 more
wiley   +1 more source

Cis‐unsaturated sphingolipids support growth of sphingoid base‐deficient yeast but impair plasma membrane integrity

open access: yesFEBS Open Bio, EarlyView.
Sphingoid base structures, the sphingolipid backbones, vary among species. We established yeast cells in which the native sphingoid base was replaced with plant‐type bases containing cis or trans double bonds. This is, to our knowledge, the first eukaryotic model mostly composed of sphingolipids containing cis‐unsaturated sphingoid base, providing a ...
Takashi Higuchi   +5 more
wiley   +1 more source

Occurrence of Manganese in the Zhaxikang Lead-Zinc Deposit from Tibet Investigated by Energy Scanning Electron Microscope and X-ray Diffraction Methods

open access: yesYankuang ceshi, 2014
The Zhaxikang Pb-Zn polymetallic ore deposit, the first SEDEX-modified by hot spring type Mn-Fe-Sb-Pb-Zn-Ag deposit discovered in China, is associated with Pb, Zn, Ag, Sb, Cu, S, Mn, As and other elements.
XU Guo-dong   +3 more
doaj  

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