Results 61 to 70 of about 198,505 (311)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Multifunctional hydrogel nano-probes for atomic force microscopy

open access: yesNature Communications, 2016
Atomic force microscopy typically employs hard tips to map the surface topology of a sample, with sub-nanometre resolution. Here, the authors instead develop softer hydrogel probes, which show potential for multifunctional measurement capabilities beyond
Jae Seol Lee   +8 more
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

Surface Chemistry at the Nanometer Scale [PDF]

open access: yes, 2011
This thesis describes research towards understanding surface chemical and physical processes, as well as their effects on the underlying substrate properties, at the nanometer and atomic scales. We demonstrate a method to tune the density of etch pits on
Cao, Peigen
core   +1 more source

High resolution atomic force and Kelvin probe force microscopy image data of InAs(001) surface using frequency modulation method

open access: yesData in Brief, 2020
This article provides data on the scanning tunnelling microscopy (STM), atomic force microscopy (AFM) and Kelvin probe force microscopy (KPFM) images of InAs(001) surface.
Young Min Park   +3 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

open access: yesFEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová   +2 more
wiley   +1 more source

Characterization of a home-built low temperature scanning probe microscopy system [PDF]

open access: yes, 2011
The continuing advancement of technology is the driving force behind science and fundamental research. Scanning probe instruments still have a major impact in nanoscience and technology, because they provide a link between the macroscopic world and ...
Thai, Quang Thanh
core   +1 more source

Atomic force microscopy in ophthalmic surgery

open access: yes4th IEEE Conference on Nanotechnology, 2004., 2005
Refractive errors are some of the most common ophthalmic abnormalities. The introduction of excimer laser technology in refractive corneal surgery aims to eliminate all or the major part of the first corneal surface optical aberrations through the modelling of the corneal surface.
MP De Santo   +4 more
openaire   +4 more sources

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

open access: yesFEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Chromosome classification by atomic force microscopy volume measurement

open access: yes, 1996
Historically, metaphase chromosomes have been differentiated (or karyotyped), within a species using chemical banding techniques and optical microscopy. This chemical approach alters the structure of the chromosomes.
Baker, A. A.   +9 more
core   +1 more source

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