Results 41 to 50 of about 882,142 (268)
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Wavelength-Dispersive Micro X-Ray Fluorescence (WDμXRF) Analysis with the microprobe [PDF]
EPJ Web of ConferencesAn Electron Probe Microanalyser (EPMA) determines the element distribution by detection of the electron beam excited characteristic X-rays using wavelength-dispersive spectrometers (WDS).
Nissen Jörg, Berger Dirk
doaj +1 more source
Electron Microscopy Redux [PDF]
International Journal of Surgical Pathology, 2011 The life history of the various techniques that have been applied over the years to diagnostic pathology shows a remarkable variation in staying power. Some, like formalin fixation, paraffin embedding, and hematoxylin–eosin staining, have remained indispensable for close to a century.
openaire +2 more sources
Molecular Oncology, EarlyView.Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani +9 more
wiley +1 more source
Experimental Biology and Medicine, 1960 SummaryA method is described by which immune systems can be studied at subcellular level with the electron microscope, using a ferritin-antibody conjugate. A conjugated immune serum to Staphylococcus aureus was applied to homologous organisms, embedded in methacrylate with uranium and thin sections cut.
C W, SMITH +3 more
openaire +2 more sources
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Molecular Oncology, EarlyView.This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan +8 more
wiley +1 more source
FEBS Open Bio, EarlyView.UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová +2 more
wiley +1 more source
Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins
FEBS Open Bio, EarlyView.Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley +1 more source
Protocol for multi-scale light microscopy/electron microscopy neuronal imaging in mouse brain tissue. [PDF]
STAR Protoc, 2022 Yamauchi K +5 more
europepmc +1 more source