Results 41 to 50 of about 6,856,460 (210)

Single‐Dose TACE‐Like Injection of Sustained‐Release Panobinostat/IL‐12 Polymeric Microparticles is Effective in Preclinical Liver Cancer Models

Advanced Science, EarlyView.
A novel PLGA/PBAE polymer microparticle platform revolutionizes intermediate‐stage liver cancer treatment by co‐delivering panobinostat and IL‐12 via a single TACE‐like injection. This sustained‐release system overcomes tumor immunosuppression, triggers robust innate and adaptive immune responses, and establishes tertiary lymphoid structures ...
Hongzhe Yu, Ling Li, Sachin S. Surwase, Xin Ming M. Zhou, Hongtao Qian, Joel C. Sunshine, Florin M. Selaru, Jordan J. Green   +7 more
wiley   +1 more source

Remote Ischemic Post‐Conditioning Preserves the Neurovascular Unit by Brain‐Derived Gas6 That Drives Monocyte‐Derived Macrophage Reprogramming via Axl and Vimentin after SAH

Advanced Science, EarlyView.
Subarachnoid hemorrhage (SAH) triggers monocyte‐derived macrophage (MDM) infiltration and M1‐like polarization via Vimentin upregulation, leading to neurovascular unit disruption and cognitive dysfunction. Remote ischemic postconditioning (RIPostC) upregulates neuronal Gas6, which activates Axl on MDMs to downregulate Vimentin and drive reparative M2 ...
Yajun Zhu, Zichao Huang, Xi Rong, Xingwei Lei, Fuming Liang, Xiaoguo Li, Jiru Zhou, Yu Wang, Yifan Huang, Shuang Tang, Jianjun Zhong, Jin Yan, Hongji Deng, Chun Zeng, Zongduo Guo   +14 more
wiley   +1 more source

Microsurgical Anatomy of the Fourth Ventricle

, 2019
Objectives:The fourth ventricle is an important midline cavity located between the pons and the cerebellum. Surgical lesions in the cavity are frequently encountered by the neurosurgical lesions. The knowledge regarding the important anatomical structure
Ümit Eroğlu
core   +1 more source

Inhibition of MEKK3 Prevents Cerebral Cavernous Malformation Progression Via Restoring Endothelial Integrity and Restricting Microglial Activation

Advanced Science, EarlyView.
In this study, we demonstrate that aberrant MEKK3 signaling in endothelial cells and microglia drives the progression of cerebral cavernous malformations (CCMs). Furthermore, we identify DPDH as a potent small‐molecule MEKK3 inhibitor with substantial therapeutic potential for CCM treatment.
Weiwei Zheng, Suyun Yu, Liwenyu Chen, Jing Ma, Peiliang Shen, Chang Yu, Xiaoqing Xin, Qiuhong Shen, Jing Chen, Song Ke, Hao Liu, Xiaobing Jiang, Ruogu Qi, Juming Yan, Jia Li, Jaesung P. Choi, Yin Lu, Yang Zhao   +17 more
wiley   +1 more source

Surgical treatment of spinal dural arteriovenous fistulas

Ukrainian Neurosurgical Journal, 2010
92 patients with dural ateriovenous fistulas (AVF), been operated from 1998 to 2010, were under observation. Open microsurgical AVF switch-off was performed in all these patients.
E. I. Slynko, A. M. Zolotoverkh
doaj   +1 more source

Silk Fibroin for Cardiovascular Medical Devices: Review of Material Properties, Applications, and Clinical Potential

Advanced NanoBiomed Research, EarlyView.
Silk fibroin is an attractive natural biomaterial that can be engineered into diverse cardiovascular constructs, including vascular grafts, cardiac patches, heart valves, and stent coatings. Its tunable biological and mechanical properties have driven substantial preclinical progress; however, widespread clinical translation in cardiovascular ...
Mahsa Haghighattalab, Matt Govendir, Kristina Andelovic, Zachary Och, Fatemeh Karimi, Munira Xaymardan, Tomasz Jungst, Jelena Rnjak‐Kovacina, Nona Farbehi   +8 more
wiley   +1 more source

Microsurgical reconstruction of the head and neck - Current practice of maxillofacial units in Germany, Austria, and Switzerland

, 2011
Refinement in microvascular reconstructive techniques over the last 30 years has enabled an increasing number of patients to be rehabilitated for both functional and aesthetic reasons.
Zeilhofer, Hans Florian, Nils Schuck, Jürgen Hoffmann, Hans-Florian Zeilhofer, Frank Hölzle, Kerkmann, Heiko, Schuck, Nils, Katinka Kansy, Hoffmann, Jürgen, Thomas Mücke, Mücke, Thomas, Heiko Kerkmann, Hölzle, Frank, Kansy, Katinka, DÖSAK collaborative group for Microsurgical Reconstruction,, Müller, Andreas Albert, Hallermann, Wock, Wock Hallermann, Andreas Albert Müller, Zeilhofer, Hans-Florian   +19 more
core   +1 more source

Combined Endovascular and Microsurgical Management of Complex Cerebral Aneurysms

Frontiers in Neurology, 2013
Cerebral aneurysms are associated with a 50% mortality rate after rupture and patients can suffer significant morbidity during subsequent treatment. Neurosurgical management of both ruptured and unruptured aneurysms has evolved over the years.
Omar eChoudhri, Nitin eMukerji, Gary K Steinberg, MD, PhD   +2 more
doaj   +1 more source

Surgical Treatment of Male Infertility

Düzce Tıp Fakültesi Dergisi, 2022
Male infertility may occur due to obstructive and non-obstructive reasons, and some pathologies may be corrected with surgical and medical treatment.
Selahittin Çayan
doaj   +1 more source

Vascularization of the Ulnar Nerve: Anatomical Feasibility as a Vascularized Nerve Graft for Contralateral C7 Transfer

Clinical Anatomy, EarlyView.
ABSTRACT Recent advances in brachial plexus reconstruction have highlighted the potential advantages of vascularized nerve grafts for functional recovery in high‐priority nerve injuries. This anatomical study evaluated the extrinsic vascular supply of the ulnar nerve based on the superior ulnar collateral artery (SUCA) in the arm, aiming to assess its ...
M. Rosa Morro‐Martí, Pablo Martínez‐Collado, Amer Mustafa‐Gondolbeu, Guillermo Tarnawski‐Español, Anna Carrera‐Burgaya, Joaquim Casañas‐Sintes, Anton Fornieles‐Espinel, Manuel Llusá‐Pérez   +7 more
wiley   +1 more source