Results 131 to 140 of about 148,622 (241)

Spatial Transcriptomic Analysis Reveals HDAC Inhibition Modulates Microglial Dynamics to Protect Against Ischemic Stroke in Mice

Glia, EarlyView.
Spatial transcriptomic analysis unravels the mechanisms by which HDACi ameliorates neuroinflammation and enhances neuroprotection by modulating the expression of microglial transcriptomes in the ischemic mouse brain. ABSTRACT Ischemic stroke significantly contributes to global morbidity and disability through a cascade of neurological responses ...
Kevin Jayaraj, Ritesh Kumar, Sukanya Shyamasundar, Thiruma V. Arumugam, Jai S. Polepalli, S. Thameem Dheen   +5 more
wiley   +1 more source

Push out bond strength of resin -based endodontic sealer loaded with silver gold nanoparticles in vitro study. [PDF]

BDJ Open
Hassan N, Riad M, Ibrahim SH, Abulnoor BA, Hassan R.   +4 more
europepmc   +1 more source

Lithocarpus polystachyus Rehd. leaves aqueous extract inhibits learning and memory impairment in Alzheimer's disease rats: Involvement of the SIRT6/NLRP3 signaling pathway

Ibrain, EarlyView.
The findings of this study demonstrate that STAE effectively counteracts the learning and memory impairment induced by Aβ25‐35 in rats. This effect is attributed, at least in part, to the regulation of the SIRT6/NLRP3 signaling pathway, which inhibits neuroinflammation and oxidative stress.
Wendan Wu, You Yan, Tingting Yi, Yu Wei, Jianmei Gao, Qihai Gong   +5 more
wiley   +1 more source

snPATHO-seq: A Detailed Protocol for Single Nucleus RNA Sequencing From FFPE. [PDF]

Bio Protoc
Arjumand W, Wise K, DuBose H, Plummer JT, Martelotto LG.   +4 more
europepmc   +1 more source

Safety Evaluation of Serendipity Berry Sweet Protein From Komagataella phaffii

Journal of Applied Toxicology, EarlyView.
ABSTRACT Serendipity Berry Sweet Protein (sweelin) is a novel hyper‐sweet thermophilic protein designed using Artificial Intelligence Computational Protein Design (AI‐CPD) to improve the stability and sensory profile of the protein found in serendipity berry (Dioscoreophyllum cumminsii).
Yael Lifshitz, Shira Paz, Rotem Saban, Inbar Zuker, Hagay Shmuely, Katy Gorshkov, Jwar Meetro, Shahrzad Tafazoli, Trung Vo, Gabriela Amiram, Carmit Shani Levi, Uri Lesmes, Ilan Samish   +12 more
wiley   +1 more source

A Protocol for Laser-Assisted Microdissection and tRF & tiRNA Sequencing in Lung Adenocarcinoma. [PDF]

Bio Protoc
Wang Z, Wang Q, Xu L, Mao Q, Jiang F.
europepmc   +1 more source

Optimized reconstruction of the absorption spectra of kidney tissues from the spectra of tissue components using the least squares method

Journal of Biophotonics, EarlyView.
The absorption coefficient spectra of healthy and cancerous kidney tissues were reconstructed from the absorption spectra of tissue components using constant weights. Both reconstructions allowed to calculate the concentrations of the tissue components and a comparison between the healthy and chromophobe renal cell carcinoma kidney showed an increase ...
Maria R. Pinheiro, Luís E. Fernandes, Isa C. Carneiro, Sónia D. Carvalho, Rui M. Henrique, Valery V. Tuchin, Hélder P. Oliveira, Luís M. Oliveira   +7 more
wiley   +1 more source

Protocol for the dissociation of adult human primary cardiomyocytes using a methylcellulose-supplemented digestion solution. [PDF]

STAR Protoc
Shi X, Huang Y, Zhou B.
europepmc   +1 more source

Analysis of the experimental absorption spectrum of the rabbit lung and identification of its components

Journal of Biophotonics, EarlyView.
The broadband absorption coefficient spectrum of the rabbit lung was reconstructed from the absorption spectra of tissue components. The similar accumulation of melanin and lipofuscin was retrieved from the broadband baseline in the absorption coefficient spectrum, and the calculation of the absorption fold ratios for proteins, DNA and hemoglobin ...
Maria R. Pinheiro, Valery V. Tuchin, Luís M. Oliveira   +2 more
wiley   +1 more source

A Quantitative Particle Identification (QPID) spectral autoradiography system. [PDF]

Commun Eng
Adler SS, Sato N, Baidoo KE, Lin FI, Lee W, Olkowski CP, Escorcia FE, Choyke PL.   +7 more
europepmc   +1 more source