Results 141 to 150 of about 92,130 (198)

Nucleus accumbens shell electrical lesion attenuates seizures and gliosis in chronic temporal lobe epilepsy rats

open access: yesEpileptic Disorders, EarlyView.
Abstract Objective Temporal lobe epilepsy (TLE) is the most prevalent form of epilepsy. Prior research has indicated the involvement of the nucleus accumbens shell (NAcSh) in the process of epileptogenesis, thereby implying its potential as a therapeutic target for TLE.
Shuaishuai Xue   +10 more
wiley   +1 more source

Development of a Zebrafish Embryo‐Based Test System for Thyroid Hormone System Disruption: 3Rs in Ecotoxicological Research

open access: yesEnvironmental Toxicology and Chemistry, EarlyView.
Abstract There is increasing concern regarding pollutants disrupting the vertebrate thyroid hormone (TH) system, which is crucial for development. Thus, identification of TH system–disrupting chemicals (THSDCs) is an important requirement in the Organisation for Economic Co‐operation and Development (OECD) testing framework.
Lisa Gölz   +9 more
wiley   +1 more source

Engineered Exosome‐Based Senolytic Therapy Alleviates Stroke by Targeting p21+CD86+ Microglia

open access: yesExploration, EarlyView.
We identified a harmful immune cell type, p21+CD86+ microglia, driving post‐stroke inflammation and developed a targeted exosome‐based therapy (Que@micro‐Exo) to eliminate these cells. This innovative treatment reduced inflammation, alleviated brain damage, and improved recovery in stroke models, offering a promising strategy for stroke and other ...
Jialei Yang, Shipo Wu, Miao He
wiley   +1 more source

High‐Precision, Low‐Threshold Neuromodulation With Ultraflexible Electrode Arrays for Brain‐to‐Brain Interfaces

open access: yesExploration, EarlyView.
Traditional neuromodulation using rigid electrodes has been limited by low precision, large stimulating currents, and the risk of tissue damage. In this work, we developed a biocompatible flexible electrode array that allows for both neural recording of spike firings and high‐precision, low‐threshold stimulation for neuromodulation.
Yifei Ye   +16 more
wiley   +1 more source

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