Results 181 to 190 of about 148,622 (241)

IGF2‐Reprogrammed Macrophages Ameliorate the Inflammatory Response and Protect Against the Neuroinflammatory Process in Parkinson's Disease Models

Aging Cell, EarlyView.
Therapeutic Effects of IGF2‐Reprogrammed Macrophages (MIGF2) in Parkinson's Disease Progression in ASO Mice: This graphical abstract illustrates the therapeutic potential of IGF2‐reprogrammed macrophages (MIGF2) in mitigating Parkinson's disease progression in ASO mice.
Felipe Grunenwald, Tomas J. Huerta, Denisse Sepulveda, Carolina Jerez, Valentina Urbina, Bárbara Carrera, Rodrigo Diaz‐Espinoza, Esteban Nova, Rodrigo Pacheco, Elisa Martín‐Montañez, Sara Gil‐Rodriguez, Nadia Valverde, María Garcia‐Fernandez, Carlos Aguilera, Pedro Chana‐Cuevas, René L. Vidal   +15 more
wiley   +1 more source

Statistical analysis of EBSD data confirms pronounced classical and non-classical pervasive crystallographic twinning in rotaliid foraminiferal calcite. [PDF]

Sci Rep
Schmahl WW, Yin X, Lastam J, Griesshaber E, Hoerl S, Sturm E, Vaquer AS.   +6 more
europepmc   +1 more source

Fall 2008, McGee Donates Book Profits to CIE in Memory of Bob LeBlanc [PDF]

, 2008
Giguere, Michelle
core   +1 more source

Targeting ATF6α Attenuates UVB‐Induced Senescence and Improves Skin Homeostasis by Regulating IL8 Expression

Aging Cell, EarlyView.
UVB exposure can trigger senescence in dermal fibroblasts. We show that silencing ATF6α disrupts the establishment of the UVB‐induced senescent phenotype by preventing the onset of several senescent biomarkers and altering the composition of the SASP, consequently affecting its impact on the skin microenvironment.
Joëlle Giroud, Pauline Delvaux, Laura Carlier, Clémentine De Schutter, Nathalie Martin, Raphaël Rouget, Ayeh Bolouki, Valérie De Glas, Inès Bouriez, Florent Bourdoux, Sophie Burteau, Julien Théry, Gauthier Decanter, Nicolas Penel, Yvan de Launoit, Benjamin Ledoux, Corinne Abbadie, Yves Poumay, Olivier Pluquet, Florence Debacq‐Chainiaux   +19 more
wiley   +1 more source

Temporally and Spatially Controlled Age-Related Prostate Cancer Model in Mice. [PDF]

Bio Protoc
Liu S, Shen K, Li Z, Rivero S, Zhang Q.
europepmc   +1 more source

Compressive Forces Induce Epigenetic Activation of Aged Human Dermal Fibroblasts Through ERK Signaling Pathway

Aging Cell, EarlyView.
Direct activation and rejuvenation of aged fibroblasts through the application of mechanical forces in a 3D spheroid culture model. The ERK signaling pathway was revealed as a key underlying mechanism. ABSTRACT Age‐related changes in human dermal fibroblasts (HDFs) contribute to impaired wound healing and skin aging.
Hui Liu, Luezhen Yuan, Lucrezia Baldi, Trinadha Rao Sornapudi, G. V. Shivashankar   +4 more
wiley   +1 more source

PCR-Based Genotyping of Zebrafish Genetic Mutants. [PDF]

Bio Protoc
Babu S, Nishiwaki Y, Masai I.
europepmc   +1 more source

Senescent Endothelial Cells in Cerebral Microcirculation Are Key Drivers of Age‐Related Blood–Brain Barrier Disruption, Microvascular Rarefaction, and Neurovascular Coupling Impairment in Mice

Aging Cell, EarlyView.
Senolytic therapy restores neurovascular function, blood–brain barrier integrity, and cognitive performance in aged mice by targeting endothelial senescence. Findings highlight that brain microvascular endothelial cells are highly vulnerable to aging‐induced senescence, and early intervention in middle age may be the most effective strategy to prevent ...
Boglarka Csik, Ádám Nyúl‐Tóth, Rafal Gulej, Roland Patai, Tamas Kiss, Jordan Delfavero, Raghavendra Y. Nagaraja, Priya Balasubramanian, Santny Shanmugarama, Anna Ungvari, Siva Sai Chandragiri, Kiana Vali Kordestan, Mark Nagykaldi, Peter Mukli, Andriy Yabluchanskiy, Sharon Negri, Stefano Tarantini, Shannon Conley, Tae Gyu Oh, Zoltan Ungvari, Anna Csiszar   +20 more
wiley   +1 more source

Aging‐Associated Vacuolation of Multi‐Ciliated Cells in the Distal Mouse Oviduct Reflects Unique Cell Identity and Luminal Microenvironment

Aging Cell, EarlyView.
Multi‐ciliated cells in the infundibulum and ampulla (INF/AMP) epithelium are vacuolated in aging. Unique cellular susceptibility of the INF/AMP epithelial population and aging‐associated decline in ovarian artery circulation, which supports the ovary and INF/AMP, contribute to this region‐specific vacuolation phenotype, as a consequence of a mildly ...
Keerthana Harwalkar, Nobuko Yamanaka, Alain S. Pacis, Selina Zhao, Katie Teng, Warwick Pitman, Mitaali Taskar, Vera Lynn, Alex Frances Thornton, Matthew J. Ford, Yojiro Yamanaka   +10 more
wiley   +1 more source

Gynura procumbens leaf extract-loaded self-microemulsifying drug delivery system offers enhanced protective effects in the hepatorenal organs of the experimental rats. [PDF]

PLoS One
Shill MC, Jalal MFB, Shuma ML, Mollick PP, Muhit MA, Halder S.   +5 more
europepmc   +1 more source