Results 161 to 170 of about 523,138 (303)

Nanozyme‐Reinforced miR‐197‐3p Delivery Resets Metabolic and Senescence Pathways to Rejuvenate Osteoarthritic Cartilage

open access: yesAdvanced Science, EarlyView.
ABSTRACT Osteoarthritis (OA) is a progressive and disabling joint disease driven by oxidative stress, chondrocyte senescence and extracellular matrix (ECM) degradation, yet lacks effective disease‐modifying treatments. In this study, we identified miR‐197‐3p as a previously unrecognized, cartilage‐protective miRNA significantly downregulated in both ...
Xuejie Cai   +11 more
wiley   +1 more source

Fully Programmable Slow Light Based on a Spinor Representation of Generalized Coupled‐Resonator‐Induced Transparency

open access: yesAdvanced Science, EarlyView.
A programmable coupled‐resonator‐induced transparency (CRIT) platform is proposed, generalizing classical electromagnetically induced transparency (EIT) via a spinor representation. By utilizing dual‐channel gauge fields and universal unitary operations, this architecture enables dynamically engineered, reconfigurable slow‐light bands on a silicon ...
Seungkyun Park   +5 more
wiley   +1 more source

Pathological Copper Overload Reprograms SOD1 Activation via COMMD1 to Promote Senescence and Fibrosis

open access: yesAdvanced Science, EarlyView.
This study uncovers a previously unrecognized copper‐COMMD1‐SOD1 regulatory axis, revealing that pathological copper overload paradoxically suppresses SOD1 activity by promoting COMMD1‐dependent disruption of SOD1 homodimerization. These findings redefine the regulatory role of copper in SOD1 biology and provide novel mechanistic insight into the ...
Yuqing Liu   +7 more
wiley   +1 more source

Introducing Borsantrazole: A Trifunctional Boron‐Based Pyrazole That Extends the Lifespan of Amyotrophic Lateral Sclerosis Mice

open access: yesAdvanced Science, EarlyView.
Herein we report a boron‐based pyrazole, (Borsantrazole ‐ a small molecule that selectively targets oxidative stress) that significantly increases survival, reduces weight loss, delays disease onset, and affects global protein changes in the SOD1‐G37R mouse model of ALS.
Nitesh Sanghai   +9 more
wiley   +1 more source

Kresling Origami‐Based Metamaterial Robot for Dynamic Electromagnetic Control

open access: yesAdvanced Science, EarlyView.
A reconfigurable metamaterial system integrates deformable origami units with high‐permittivity ceramic plates. Pneumatic switching between structural states alters local resonance conditions, enabling dynamic radar stealth and adaptive microwave reflection for mobile communication.
Xinxi Zeng   +13 more
wiley   +1 more source

Néel‐Vector‐Dependent Unconventional Spin‐Orbit Torque for Deterministic Field‐Free Switching in NiO (110)‐Based Trilayers

open access: yesAdvanced Science, EarlyView.
Unconventional spin currents are generated in an antiferromagnetic NiO(110)/Ta/CoFeB trilayer, where the Néel vector governs spin transport. The resulting spin–orbit torques enable deterministic field‐free switching of perpendicular magnetization.
Hyeong‐Joo Seo   +12 more
wiley   +1 more source

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