Results 151 to 160 of about 1,276,832 (305)

Dual pKa Lipid Nanoparticles for Lung‐tropic mRNA Delivery and pH‐Programmed Endosomal Escape

Advanced Science, EarlyView.
Lipid nanoparticles’ bottleneck lies in low endosomal escape efficiency and liver‐dominant delivery after intravenous administration. To overcome these limitations, we present a stepwise pH‐programmed lipid nanoparticle system enabled by our newly synthesized ionizable lipid.
Seong Gi Lim, Minju Lee, Yiming Wang, Eunjin Choi, Ji Sun Park, Kyungmin Park, Hayoung Jeon, Donghyun Kim, Donghyun Lee, Yeeun Lee, Kee‐Pyo Kim, Eunha Kim, Heebeom Koo   +12 more
wiley   +1 more source

An Optimized Freeze‐Dry Multimodal Workflow for Sequential Micro‐CT Imaging, Histology, and Molecular Profiling: A Use Case in Human Liver Fibrosis

Advanced Science, EarlyView.
Optimized freeze‐drying and eosin staining deliver artifact‐free micro‐CT images of liver tissue at near‐histological detail, then hand the same specimen back for sectioning, staining, and sequencing. Fibrotic volume distinguishes normal liver from cirrhosis, while preserved RNA reveals inflammatory gene upregulation—one biopsy, three dimensions, and a
Kristijan Skok, Laura Činč Ćurić, Jernej Vajda, Silvia Schauer, Martin Wagner, Rudolf Stauber, Carolin Lackner, Karl Kashofer, Markus Plass, Giovanny Rodriguez Blanco, Ian R. Wanless, Uroš Maver, Katrin Panzitt, Boštjan Vihar   +13 more
wiley   +1 more source

Chemotherapy‐Activated GSK3β‐DNMT1 Signaling Upregulates CD47 to Evade Macrophage Phagocytosis and Drive Temozolomide Resistance in Glioblastoma

Advanced Science, EarlyView.
Temozolomide treatment activates GSK3β, driving DNMT1 phosphorylation, destabilization, and CD47 promoter hypomethylation in glioblastoma. This epigenetic shift upregulates CD47, enabling TMZ‐treated GBM cells to evade macrophage phagocytosis, survive chemotherapy, and acquire resistance.
Jie Li, Shuai Ying, Yi Zhang, Jingjing Wang, Quan Wan, Lingli Gong, Daxing Xu, Zhenkun Yang, Hongnian Lu, Ying Yin, Xiangming Fang, Zhening Pu   +11 more
wiley   +1 more source

The Application of Microwave Heating Methods in Pharmaceutical Formulations [PDF]

This study investigated the potential application of formulating pharmaceutical products using microwave heating methods alongside associated analytical investigations.
Bedford, Susan
core   +1 more source

AHR‐Responsive Carbon Dots Orchestrate Skin Wound Healing and Colonic Mucosal Repair via Treg‐Mediated Macrophage Efferocytosis

Advanced Science, EarlyView.
Guided by pharmacophore modeling and molecular docking, aryl hydrocarbon receptor (AHR)‐responsive carbon dots were synthesized. They bind directly to AHR and expand gut‐resident regulatory T (Treg) cells. Treg‐derived C‐C motif chemokine ligand 1 (CCL1) enhances macrophage efferocytosis, creating a pro‐regenetative niche that promotes colonic mucosal ...
Zilu Zhu, Han Zhang, Shuai Lin, Wenqian Zheng, Xin Li, Xiaowei Xu, Ruili Yang   +6 more
wiley   +1 more source

Raspberry bush - derived magnetic nanocomposites for water purification and microwave absorption. [PDF]

Nanoscale Adv
Aslibeiki B, Imani M, Mahmoodi M, Ghosh S, Peddis D, Sarkar T.   +5 more
europepmc   +1 more source

Interfacial Salinity–Transport Matching in 3D Solar Evaporators: A Framework for Brine‐Stable Solar Interfacial Evaporation

Advanced Science, EarlyView.
A transport‐matching framework is developed to evaluate brine‐stable 3D solar evaporators beyond evaporation rate alone. Using PVA/GNP porous evaporators as a model system, the study shows that stable brine evaporation requires balanced heat generation, liquid replenishment, salt redistribution, and vapor removal rather than maximum dry temperature or ...
Mohammad Sajad Sorayani Bafqi, Arun Prakash Aranga Raju, Omid Doustdar, Reza Nekouie Esfahani, Ali Sadaghiani   +4 more
wiley   +1 more source

Regional Segregated Architecture Strategy for High-Efficiency Microwave Absorption of Polyimide Foam. [PDF]

Small Methods
Li N, Li ZY, Zhang F, Shi JF, Zong Z, Xu HK, Zhang YF, Chen YM, Deng ZH, Wang YY, Yan DX, Li ZM.   +11 more
europepmc   +1 more source

Dual‐Functional Terahertz Manipulation of EuBa2Cu3O7 Superconductors via Cooper Pair Dynamics

Advanced Science, EarlyView.
We use a spintronic‐metasurface THz emitter to realize chiral THz generation. Using polarization‐tunable THz pulses, we investigate equilibrium and photoinduced THz responses in a 43 nm thick EuBa2Cu3O7 (EBCO) thin film. The EBCO film achieves 46.81 dB EMI shielding and 113% photoinduced THz modulation with 19.0 ps recovery, enabled by Cooper‐pair ...
Zhangshun Li, Meng Yang, Zuanming Jin, Junxue Li, Zhiqiang Lan, Chen Huang, Alexei V. Balakin, Alexander P. Shkurinov, Yan Peng, Yiming Zhu, Songlin Zhuang   +10 more
wiley   +1 more source

Low-Carbon-Residue Multi-Principal-Element Magnetic Alloys for Excellent Microwave Absorption. [PDF]

Small Methods
Ma D, Wen M, Wang Z, He J, You W, Zhu G, Wu L, Che R.   +7 more
europepmc   +1 more source