Results 151 to 160 of about 32,670 (315)

DOT1L Drives Endothelial‐to‐Mesenchymal Transition and Fibrotic Vascular Remodeling via H3K79 Methylation

Advanced Science, EarlyView.
DOT1L as a central epigenetic regulator of EndoMT and pulmonary fibrosis. Acting as an early epigenetic switch, it translates TGFβ–SMAD signaling into H3K79me2‐mediated chromatin remodeling, selectively activates fibrosis‐related genes, and primes ECs for rapid mesenchymal transition.
Yaofeng Wang, Xing Peng, Jingjing Chen, Yun Zhang, Tinghong Zhang, Jingyuan Zhang, Jiaying Fan, Hui Zheng, Qiaoyuan Liu, Zhimin Song, Zhan‐Peng Huang, Shu Meng   +11 more
wiley   +1 more source

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source

Gene Expression in Saccharomyces cerevisiae exposed at microwaves

, 2009
This work is focused on the effects of microwaves at the frequency of 2.45 GHz, power density of 5mW/cm2 for 0, 10, 30 and 60 minutes exposure on Saccharomyces cerevisiae strain D7. The effects of microwaves on DNA damage have been evaluated as induction
CIPOLLINI, MONICA
core  

Lipid Extraction and Cell Disruption Methods for Improving Biodiesel Production by <i>Scenedesmus sp</i>. [PDF]

Microorganisms
Raya MPP, Martínez Cartas ML, Sánchez S.   +2 more
europepmc   +1 more source

PRMT1‐Mediated LDHA Methylation Drives STAT3 Lactylation to Orchestrate Intestinal Inflammation and Tumorigenesis

Advanced Science, EarlyView.
This study identifies an immunometabolic axis wherein SAM‐driven PRMT1 methylates LDHA, enhancing its activity. The resultant lactate induces STAT3 K709 lactylation, which stabilizes an active conformation to promote STAT3 phosphorylation and IL‐10 expression.
Hui Wang, Mengyu Zhang, Weipeng Gong, Jiaxuan Wu, Junping Zhang, Wenxiu Zhang, Yue Liu, Kui Wang, Canhua Huang, Jun Zhou, Sijin Wu, Yan Li, Tianliang Li   +12 more
wiley   +1 more source

Application of microwaves in food’s thermal treatment

, 2009
W artykule przedstawiono różne możliwości zastosowania mikrofal do obróbki cieplnej żywności. Szeroko omówiono zalety mikrofalowego temperingu mięsa, suszenia produktów spożywczych oraz innych procesów ogrzewania, w których mikrofale są coraz szerzej ...
Perek, A., Dolata, W.
core  

Advances in the Use of Microwaves for Isolation and Structural Modification of Biobased Polysaccharides. [PDF]

ACS Omega
Dos Santos EMG, Lopes Fernandes Júnior E, de Lima Maniçoba G, Leão AD, de Jesus Oliveira AC, Chaves LL, De La Roca Soares MF, Soares-Sobrinho JL.   +7 more
europepmc   +1 more source

Heme‐NO Dilates Arteries via Mobilization of NO Moieties From an Intracellular NO Store Within Vascular Smooth Muscle Cells

Advanced Science, EarlyView.
Nitrosyl heme emerges as an extracellular nitrodilator that dilates arteries without crossing the cell membrane. Instead, heme‐NO mobilizes NO moieties from a preformed intracellular NO store within vascular smooth muscle, providing both functional and chemical evidence for the NANOS model, revealing a previously unrecognized mechanism of arterial ...
Taiming Liu, Meijuan Zhang, Lingchao Zhu, Haiyan Ke, Amancio de Souza, Qian Li, Daniel Castella, Nicolai Lehnert, Lubo Zhang, Arlin B. Blood   +9 more
wiley   +1 more source

Imaging cell phone radiation in tissue mimics with hyperpolarized low-field MRI. [PDF]

Sci Adv
Ogier SE, Russek SE, Martinez JA, Betz KM, Stupic KF, Watterson WJ, Simons MT, Holloway CL, Biller JR, Srivastava DJ, Teixeira RPAG, Keenan KE.   +11 more
europepmc   +1 more source

Gemella morbillorum Promotes Colorectal Carcinogenesis: LPBDCP‐Mediated Invasion Activates Ras Signaling and Destabilizes p53

Advanced Science, EarlyView.
ABSTRACT Gut microbiota dysbiosis promotes colorectal cancer (CRC) tumorigenesis. A global fecal metagenomic analysis identified Gemella morbillorum as a key contributor to the CRC‐associated microbiota. Fluorescence in situ hybridization revealed that Gemella morbillorum is enriched in CRC tumor tissues compared to adjacent normal tissues.
Zhen Wang, Jia Zhang, Haojie Lu, Jingjing Ni, Shuaishuai Yang, Yuting Shi, Shuo Zhang, Pei Zhang, Li Liu   +8 more
wiley   +1 more source