Results 101 to 110 of about 1,932,630 (281)

Two-Step Acceleration Model of Cosmic Rays at Middle-Aged SNR

, 2010
Recent gamma-ray observations of middle-aged supernova remnants revealed a mysterious broken power-law spectrum. Using three-dimensional magnetohydrodynamics simulations, we show that the interaction between a supernova blast wave and interstellar clouds
Abdo, Abdo, Abdo, Abdo, Abdo, Aharonian, Buckley, Giacalone, Heitsch, Inoue, Inoue, Inoue, Inoue, Koyama, Koyama, Landau, Li, Malkov, Malkov, Melrose, Ohira, Sakamoto, Sano, Uchiyama   +23 more
core   +1 more source

Loss of Immunohistochemical Reactivity in Association With Handling-Induced Dark Neurons in Mouse Brains. [PDF]

, 2020
The handling-induced dark neuron is a histological artifact observed in brain samples handled before fixation with aldehydes. To explore associations between dark neurons and immunohistochemical alterations in mouse brains, we examined protein products ...
Chang, Rachel C, Jeste, Dilip V, Patel, Hemal H, Schilling, Jan M, Soontornniyomkij, Benchawanna, Soontornniyomkij, Virawudh   +5 more
core  

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Examining Risky Riding Behaviors: Insights from a Questionnaire Survey with Middle-Aged and Older Motorcyclists in Thailand

Safety
This research endeavors to achieve three primary objectives. Firstly, it seeks to develop a measurement model capable of assessing the motorcycle riding behavior of middle-aged individuals in Thailand.
Sayam Sunmud, Tosporn Arreeras, Suchada Phonsitthangkun, Sirin Prommakhot, Krit Sititvangkul   +4 more
doaj   +1 more source

INTEGRAL observations of TeV plerions

, 2006
Amongst the sources seen in very high gamma-rays several are associated with Pulsar Wind Nebulae (``TeV plerions''). The study of hard X-ray/soft gamma-ray emission is providing an important insight into the energetic particle population present in these
A. Achterberg, A. Goldwurm, A. I. D. Hoffmann, A. Santangelo, A.J. Bird, C. Masterson, C.-Y. Ng, D. Horns, D. Horns, F. Aharonian, F. Aharonian, F. Aharonian, J. Arons, J. Kirk, J. Niemiec, J.M. Blondin, M. Forot, M. Hoshino, M. Lemoine, M. Ostrowski, M.S.E. Roberts, R.N. Manchester   +21 more
core   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Functional and Diffusion-Based Microstructural Correlates in Cortical and Subcortical Substrates of Motor Performance of a Complex Visuomotor Task in Middle-Aged Adults

Journal of Integrative Neuroscience
Background: Cognitive training offers a potential approach for the prevention of cognitive decline in later life. Repetition of targeted exercises may improve, or at least preserve, both specific domain and general cognitive abilities ...
Diana Kyriazis, Makoto Uji, Samira Bouyagoub, Mara Cercignani, Paul R Ford, Natasha Sigala   +5 more
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Biallelic Inactivation of NSD1 Associated With Carcinogenesis in Sotos Syndrome

Pediatric Blood &Cancer, EarlyView.
Nicholas A. Borja, Anuja Sule, Katie Ann McMullen, Aditi Dhir, Matthew D. Hall, Heather J. McCrea, Sakir Humayun Gultekin, Mustafa Tekin, Bradley Gampel   +8 more
wiley   +1 more source