Results 41 to 50 of about 28,063 (287)

Dimensions of Memory in Elderly Compared with Non-Elderly [PDF]

open access: yesروانشناسی پیری, 2019
Growing old causes significant effects on cognitive and metacognitive processes and increases the likelihood of cognitive failure. The present study aimed to investigate various dimensions of memory in the elderly and compare it with non-elderly.
Kamran Yazdanbakhsh   +3 more
doaj  

Syllable structure in Old, Middle and Modern Persian: A contrastive analysis [PDF]

open access: yesIranian Journal of Applied Language Studies, 2015
Evolution of languages has always been of interest to linguists.  In this paper we study  the natural progress of the syllable structure from Old  Persian  (O.P)  to Middle Persian (Mi.P) and up to the Modern Persian (Mo.P).
Aliye Kord zaferanlu Kambuziya   +1 more
doaj   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

open access: yesFEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang   +8 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Crossing the Borders between Meter, Syntax and Information Structure. Some Methodological Notes

open access: yesLea, 2023
This paper discusses how combining research in meter, syntax and information structure can enhance our understanding of the syntax of a given historical text and help provide insights into the relation between metrical prominence and information ...
Chiara De Bastiani
doaj   +1 more source

Comparison of Coherence and Efficiency in Discourse Production of Middle-old and Old-old Elderly [PDF]

open access: yesAudiology and Speech Research, 2019
Purpose: The purpose of this study was to compare the degree of coherence and efficiency in the discourse production of cognitively healthy middle-old...
Bo Seon Kim, Mi Sook Lee
openaire   +1 more source

‘Je sais et tout mais...’ might the general extenders in European French be changing? [PDF]

open access: yes, 2014
This paper addresses contemporary trends in the use of general extenders in two recent corpora of spontaneous French stratified by age. In these corpora, certain variants (e.g. et tout) are highly prevalent in the speech of young people compared to older
Aijmer   +26 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

COVID in oldest old: What we learnt in a tertiary care hospital emergency

open access: yesArchives of Gerontology and Geriatrics Plus
Background: COVID-19 created extreme havoc among the elderly and the oldest-old bore the maximum brunt during triaging. With COVID cases again on the raise, this retrospective analysis gives an insight of the clinical spectrum and mortality in COVID-19 ...
Tejeswini CJ   +6 more
doaj   +1 more source

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