Frontiers in Public Health, 2023 PurposeExposure to perfluoroalkyl and polyfluoroalkyl substances causes oxidative stress, which is strongly associated with adverse health effects. Klotho protein plays an anti-aging role via antioxidation activity.MethodsWe investigated the levels of serum α-Klotho and PFAS exposure in adults who participated in the National Health and Nutrition ...
Min Li +7 more
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Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Some Peculiar Forms of Old English Verbs
Studia Anglica Posnaniensia, 2016 In late Old English it became common to find strange verb forms of which had less frequently appeared in earlier texts. It is clear that Old English paradigms started to modify their shapes, though their structure had never been completely established in
Ogura Michiko
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The relevance of early cognitive diagnosis in middle age or the threshold of old age—for a better quality of life for the long‐lived [PDF]
, 2021 Marcella Bianca Neves +1 more
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Statins for primary and secondary prevention in the oldest old : an overview of the existing evidence [PDF]
, 2012 Hypercholesterolemia, although a modifiable risk factor for cardiovascular disease, is still one of the leading causes of death among older people in western countries.
Petrovic, Mirko +2 more
core +1 more source
Lake sedimentological and ecological response to hyperthermals : Boltysh impact crater, Ukraine [PDF]
, 2017 Acknowledgements Initial drilling of the Boltysh meteorite crater was funded by Natural Environment Research Council (NERC) grant NE/D005043/1. The authors are extremely grateful to the valuable scientific contributions of S. Kelley and I. Gilmour.
Andrews, Steven D. +3 more
core +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Regard sur l’histoire de quelques prépositions de l’anglais contemporain :apport de la diachronie
Corela, 2017 This article considers the prepositions in the common corpus from a diachronic perspective, focusing on by, of and for, three prepositions inherited from Old English. The corpus yields one occurrence of by introducing an agent, one instance of of linking
Anne Mathieu
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The dynamics of aging of the elderly characters as American Zeitgeist in Alfred Uhry's play “Driving Miss Daisy” [PDF]
, 2017 У розвідці розглядається динаміка старіння персонажів «Водія міс Дейзі» А.Урі – драматичного твору, що репрезентує досвід, актуальний для сучасного американського суспільства, в якому стрімко збільшується середня тривалість життя. В рамках літературної
Гайдаш, Анна Владиславівна
core
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source