Results 81 to 90 of about 28,063 (287)

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

The Status of Old English Dare Revisited

Studia Anglica Posnaniensia, 2017
The development of dare in the history of English has played an important role in the literature on grammatical change and (de)grammaticalization. This paper aims to clarify two issues regarding the syntax and semantics of dare in earlier English: when ...
Gregersen Sune
doaj   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

E-Voting in an ubicomp world: trust, privacy, and social implications [PDF]

, 2008
The advances made in technology have unchained the user from the desktop into interactions where access is anywhere, anytime. In addition, the introduction of ubiquitous computing (ubicomp) will see further changes in how we interact with technology and ...
Bederson, B.B., Benaloh, J., Bryans, J., Chaum, D., Communications and Electronic Security Group., Dill, D., Electoral Commission., Electoral Commission., Electoral Commission., Federal Election Committee., Federal Trade Commission Study., Gumbel, A., Hong, J.I., Ishbel Duncan, Kimball, D.C., Kitcat, J., Langheinrich, M., Laskowski, S., Linda Little, Little, L., Maguire, M.C., McCandlish, S., Mercuri, R., Mercuri, R., Palen, L., Pam Briggs, Raisinghani, M.S., Sillence, E., Teltzrow, M., Tim Storer   +29 more
core   +3 more sources

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Associations of depressive symptoms and chronic diseases with activities of daily living among middle-aged and older population in China: A population-based cohort study [PDF]

, 2022
Yingyun Hu, Feixiang Zhou, Atipatsa Chiwanda Kaminga, Shipeng Yan, Zhao Hu   +4 more
openalex   +1 more source

Shock-induced star formation in a model of the Mice

, 2004
Star formation plays an important role in the fate of interacting galaxies. To date, most galactic simulations including star formation have used a density-dependent star formation rule designed to approximate a Schmidt law.
Aarseth, Alonso-Herrero, Barnes, Barnes, Barnes, Barnes, Burbidge, de Grijs, Dehnen, Elmegreen, Freeman, Gerin, Gerritsen, Gilbert, Gingold, Hernquist, Hernquist, Hibbard, Hibbard, Jog, Joshua E. Barnes, Katz, Kennicutt, Kormendy, Lucy, Mihos, Mihos, Mihos, Mihos, Mihos, Mihos, Mihos, Mirabel, Monaghan, Monaghan, Noguchi, Olson, Sanders, Schmidt, Schweizer, Scoville, Shu, Sotnikova, Spitzer, Springel, Stockton, Theys, Toomre, Toomre, Tremaine, van den Bergh, Vigroux, Vorontsov-Vel'yaminov, White, Whitmore, Xu, Yun, Zepf   +57 more
core   +1 more source

Exploring salient dimensions in a free sorting task: A cross-country study within the elderly population [PDF]

, 2017
Free sorting tasks have been widely applied on different age segments to study the categorization of foods. However the method has received little attention in the investigation of older adults’ perception.
Appleton, Katherine, Cliceri, D., Depezay, L., Dinnella, C., Giboreau, A., Hartwell, Heather, Monteleone, E., Morizet, D.   +7 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Association between physical capacity and occupational falls among middle-aged and older farmers in Thailand: Using the self-check risk assessment tool in Japan [PDF]

, 2021
Sara Arphorn, Teepapipat Lertvarayut, Kanpitcha Kiatkitroj, Chalermsiri Theppitak, Aniruth Manothum, Kunio Hara, Tomohiro Ishimaru   +6 more
openalex   +1 more source