Results 271 to 280 of about 11,190,774 (355)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Trends and cross-country inequalities in the global burden of subarachnoid hemorrhage, 1990-2021: a population-based study. [PDF]

Front Public Health
Li S, Li L, Zhang S, Chen X, Chen T, Liu H.   +5 more
europepmc   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Impact of AI-generated characters on visual attention and prefrontal cognitive responses across age and image type conditions: using fNIRS and eye-tracking. [PDF]

Front Hum Neurosci
Cha J, Lee N, Kim S.
europepmc   +1 more source

Middle-aged mice show delayed and destabilized food-anticipatory circadian activity under restricted feeding. [PDF]

J Physiol Sci
Ohno SN, Takasu NN, Uchida H, Nakamura TJ, Nakamura W, Sugimura M.   +5 more
europepmc   +1 more source

U-Pb Detrital Zircon Geochronology and Its Tectonic Implications for the Middle Devonian at the Northwestern Margin of the Yangtze Block. [PDF]

ACS Omega
Guo T, Yang WF, Zeng L, Wang C.
europepmc   +1 more source

Authorship and citation inequities in high-impact emergency medicine journals: a bibliometric analysis. [PDF]

Afr J Emerg Med
Cakmak S, Sarbay I.
europepmc   +1 more source