Results 91 to 100 of about 1,480,064 (291)

Time, the final frontier

Molecular Oncology, EarlyView.
This article advocates integrating temporal dynamics into cancer research. Rather than relying on static snapshots, researchers should increasingly consider adopting dynamic methods—such as live imaging, temporal omics, and liquid biopsies—to track how tumors evolve over time.
Gautier Follain, Michal Dibus, Omkar Joshi, Guillaume Jacquemet   +3 more
wiley   +1 more source

“I Don’t Believe in Age; I Believe in Staying Enthusiastic”: An Exploratory Qualitative Study into Recruitment Strategies Stimulating Middle-Aged and Older Adults to Join Physical Activity Interventions

Geriatrics
Many middle-aged and older adults (MAOAs) do not engage in sufficient physical activity (PA), despite its well-documented benefits for healthy aging. Existing PA interventions often fail to reach or engage the target population effectively.
Janet M. Boekhout, Rieteke Hut, Lilian Lechner, Denise A. Peels   +3 more
doaj   +1 more source

An Introduction to the Economic History of England: The Middle Ages. [PDF]

, 1915
J. H. Clapham, E. Lipson
openalex   +1 more source

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

Molecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder   +11 more
wiley   +1 more source

Experience in treating middle⁃aged and elderly patients with brain trauma⁃induced coagulopathy in primary hospitals

Chinese Journal of Contemporary Neurology and Neurosurgery, 2019
Objective This paper summarized the experience in treating middle⁃aged and elderly patients with brain trauma⁃induced coagulopathy (BTIC). Methods and Results From January 2015 to May 2019, 3 BTIC patients (50-85 years old) were diagnosed by clinical ...
Zhu⁃feng GAO, Xiao⁃feng XU, Yong⁃qiang MAO, Shao⁃fei NI, Ying ZOU, Long⁃xing CAO   +5 more
doaj  

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Cognitive impairment and depressive symptoms: effects on functional disability, falls, hospitalization, and polypharmacy in a longitudinal follow-up

ABCS Health Sciences
Introduction: The ageing process is associated with a higher prevalence of depression and cognitive impairment, negatively affecting health. Objective: Analyse the effects of cognitive impairment and depressive symptoms on the risk of functional ...
Milla Bitencourt Cabral, Nathalia de Oliveira Andrade, Allan Gustavo Bregola, Marcelo Kwiatkoski, Tatiana Carvalho Reis Martins, Bruna Moretti Luchesi   +5 more
doaj   +1 more source

Jewish Life in the Middle Ages. Israel Abrahams [PDF]

, 1898
Joseph K. Arnold
openalex   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

The Palace of Minos, a Comparative Account of the Successive Stages of the Early Cretan Civilization as Illustrated by the Discoveries at Knossos. Volume I: The Neolithic and Early and Middle Minoan Ages. By Sir Arthur Evans [PDF]

, 1922
Edith Hall Dohan
openalex   +1 more source