Results 91 to 100 of about 1,533,855 (292)
Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed+8 more
wiley +1 more source
Notes on Æsopic Fable Literature in Spain and Portugal During the Middle Ages. [PDF]
George C. Keidel
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Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho+11 more
wiley +1 more source
Law and Politics in the Middle Ages. By EDWARD JENKS, M. A., Reader in English Law in the University of Oxford. Pp. 352. Price, $2.75. New York: Henry Holt& Co., I898 [PDF]
Fmdbric C. Howe
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Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski+19 more
wiley +1 more source
Emotional Symptoms and Health Complaints for Patients Seeking Psychomotor Physiotherapy
Aim: Because patients seeking Norwegian psychomotor physiotherapy (PMF) rarely have been described with validated, psychometrically sound instruments, we used six questionnaires to characterize these patients in terms of subjective health complaints and ...
Monica H. Breitve+2 more
doaj
Resumo Objetivo : Mensurar a melhora do equilíbrio estático em indivíduos da terceira idade com a prática da equoterapia. Materiais e métodos : estudo experimental, clínico, pré e pós-teste.
Tiago Toigo+2 more
doaj +1 more source
On the Occurrence of Retinal Hemorrhage after Middle Age, and Its Bearing on the Duration of Life [PDF]
Hasket Derby
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This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau+9 more
wiley +1 more source
Purpose: Disturbances in balance and also regaining the balance strategy is very important in the middle-aged women who are near their menopause and subject to severe hormonal and physiological changes, reduced muscle strength, and decreased bone density.
Niloufar Rahmani+2 more
doaj